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The Pavlovian Paradox: Mosquitoes Learn to Associate DEET with FoodFor decades, the efficacy of DEET (N,N-diethyl-meta-toluamide) has been attributed solely to its chemical properties, which are believed to either repel insects or block their ability to detect humans. However, a new study led by Professor Claudio Lazzari from the University of Tours suggests a more complex behavioral interaction. The research indicates that mosquitoes can learn to associate the scent of DEET with the presence of a blood meal, effectively turning a repellent into a lure through a process similar to Pavlovian conditioning.Experimental Evidence: From Repellent to LureThe study, published in the Journal of Experimental Biology, involved trapping mosquitoes and presenting them with warm blood that was just out of reach. The insects were simultaneously exposed to DEET. The results demonstrated a significant shift in behavior:Trained Group: 60% of mosquitoes that fed while exposed to DEET subsequently attempted to bite when exposed to the repellent alone.Control Groups: Significantly lower percentages were observed in untrained insects (17%) and those with prior exposure to DEET alone (13%).In a real-world test, nearly 60% of the trained mosquitoes attempted to bite a researcher's DEET-treated hand, whereas untrained mosquitoes universally targeted the untreated hand.Redefining Insect Control StrategiesThis discovery represents a significant shift in our understanding of how repellents work. It suggests that the reaction to DEET is not merely a chemical aversion but can be modified by experience. Experts, including Dr. Nina Stanczyk of ETH Zürich, emphasize that while the learning ability of mosquitoes is impressive, the implications for public health are nuanced. The study highlights that repellents may function differently depending on the context of the mosquito's previous interactions with humans.Future Outlook for TravelersDespite the alarming findings, experts urge travelers not to abandon DEET. The consensus is that this phenomenon occurs under specific laboratory conditions and is unlikely to happen frequently in the wild due to the variability of repellents encountered during different blood meals. The key takeaway for the future is the importance of consistent application. As noted by the researchers, the risk of association is highest when the repellent starts to wear off, reinforcing the need for regular reapplication to maintain protection.

The LeadA daily pill has shown remarkable results in doubling survival time for patients with pancreatic cancer, the world's deadliest form of the disease. According to clinical trial results presented at the American Society of Clinical Oncology's annual meeting, this breakthrough treatment represents a potential revolution in how we approach a cancer that has seen limited progress for decades.The Breakthrough Drug: DaraxonrasibThe drug in question, daraxonrasib, works by targeting a protein called Kras that fuels nearly all pancreatic cancers. This mechanism represents a significant advancement in treatment strategy, as Kras has been notoriously difficult to target effectively. The drug functions as a Ras(On) multi-selective inhibitor, capable of turning off the Kras protein to stop cancer growth regardless of which variant is present.Impressive Trial ResultsIn the clinical trial involving 500 patients with advanced pancreatic cancer, the results were striking. Those who took daraxonrasib lived an average of 13.2 months, compared to just 6.6 to 6.7 months for patients who received chemotherapy. This represents a near doubling of survival time, with the added benefit of fewer side effects compared to traditional chemotherapy treatments.Industry Impact and Expert ReactionsThe findings have been hailed as a "gamechanger" and "grand slam" by experts in the field. Dr. Rachna Shroff, chief of oncology at the University of Arizona Cancer Center, described the results as "landscape-changing" and "unprecedented survival." When she first read the trial results, conducted by researchers at the Dana-Farber Cancer Institute in Boston, she wept, noting the profound impact this could have on patients after 16 years of treating pancreatic cancer.Dr. Julie Gralow, Asco's chief medical officer, echoed these sentiments, calling the study a "home run" and suggesting it was actually a "grand slam" in terms of its significance.The Ras RevolutionOver 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene. This discovery has long been considered the "holy grail" in cancer research, particularly for pancreatic cancer where the mutation is nearly ubiquitous and an early driver of cancer growth.Paula Hanford, chief executive of UK-based Pancreatic Cancer Action, called this one of the most significant developments in treatment she had ever seen. Similarly, Anna Jewell, director of services, research and innovation at Pancreatic Cancer UK, described the results as "exciting," noting that the drug gives patients "months more precious time with their loved ones."Future Outlook and ApplicationsThe success of daraxonrasib opens doors for similar treatments targeting Ras genes in other cancers. Experts at the conference noted that because Ras genes fuel various types of cancer, there is hope for breakthroughs in treating lung and colon cancers as well, with similar drugs already in development for these conditions.However, challenges remain in ensuring these promising treatments become widely available to patients. As Jewell pointed out, tragically half of all people with pancreatic cancer die within just three months of diagnosis, making the rapid implementation of such treatments crucial.

Iga Swiatek's Unhappy Birthday at French Open Iga Swiatek's 25th birthday celebrations turned sour at the French Open on Sunday as the former champion lost 7-5, 6-1 in the fourth round to the Ukrainian 15th seed Marta Kostyuk, her challenge for a fifth title ending just when she had looked to be rediscovering her rhythm. The Match Turning Point There was little to separate the duo in the early exchanges as they twice traded breaks, before Kostyuk came up with a tight hold in the 11th game and raised her level at the end to claim the opening set with a backhand crosscourt winner. Kostyuk's Historic Win It was the first time that Kostyuk had taken a set off the third-seeded Pole after three straight-set defeats in their previous meetings, and she sensed a big upset when she went ahead 3-1 in the next set after a battling effort. The Impact on Swiatek's Title Hopes The Rouen and Madrid champion held her nerve from there to take her record on clay this season to 15-0, and book a meeting with the seventh-seeded Ukrainian Elina Svitolina or the 11th-seeded Swiss Belinda Bencic in the next round at Roland Garros. What's Next Tumaini Carayol’s report to follow

The Schreiber family, presiding over a nationwide commercial portfolio via the Midos Group, is at the center of a growing controversy involving two distinct business models: aggressive tax avoidance and the profiteering from the UK's housing crisis. The Dual Nature of the Schreiber Business Empire The investigation reveals a complex web of family-owned entities that appear to operate on opposite ends of the social spectrum. On one side, the Midos Group is accused of exploiting a controversial tax scheme to avoid business rates on empty commercial properties. On the other, a similarly named but ostensibly separate entity, Midos Management Co, is profiting from the UK's chronic shortage of social housing by arranging temporary accommodation for homeless residents. Midos Group: Accused of using the 'faith room' scheme to avoid rates on empty units. Midos Management Co: Collecting fees for arranging temporary accommodation for councils. Key Figures: David Schreiber (Midos Group) and Elizabeth Endzweig (Midos Management Co). Financial Impact of the 'Faith Room' Tax Loophole The core of the tax avoidance allegations centers on a provision that exempts property owners from paying business rates if the space is made available for religious worship. The 'faith room' scheme, marketed by Verity, allegedly involves minimal activity—such as placing a notice and a staff member reading scripture—to create the appearance of worship. Total Savings: Landlords have saved at least £18m through this scheme. Specific Case: Dover District Council is suing for £1.7m of unpaid tax. Properties Involved: Discovery Park in Kent and a disused pub in Clapham, London. Profiting from the Homelessness Crisis While the family allegedly avoids taxes on empty buildings, they are simultaneously capitalizing on the housing emergency. Midos Management Co acts as an intermediary, matching councils with private landlords to house homeless residents. Despite claims of separation, evidence suggests significant overlap between the two entities. Revenue Collected: At least £43m collected on behalf of landlords since 2019. Client Base: Lambeth council and at least four other councils. Directorship Overlap: Elizabeth Endzweig, daughter of David Schreiber, is a co-director of multiple companies sharing the same address as Midos Group. The Future of UK Property Tax Compliance The revelations highlight a growing tension between private profit and public service obligations. With MPs and councils increasingly scrutinizing these arrangements, the 'faith room' exemption is likely to face tighter regulatory oversight. The case sets a precedent for how closely connected family businesses can be without violating anti-avoidance rules, potentially leading to stricter audits of corporate structures in the property sector.

Uncovering Family History Through Fiction Maggie O'Farrell's journey into her family's past began with a childhood myth about an ancestor who worked on the first maps of Ireland. Years later, a hand-drawn map and an old photograph led her to discover the truth about her great-great-grandfather's role in the Ordnance Survey. The Mapper's Story O'Farrell's ancestor was a labourer and translator who worked on mapping divisions in Ireland during the aftermath of the great famine. His task was to ensure that the changes caused by the disaster were marked on the new post-famine versions of Ireland's maps. A Window into the Past The photograph showed O'Farrell's great-great-grandfather with a child on his knee, wearing a worn jacket and a low-brimmed hat. A hand-drawn map, beautifully rendered in coloured inks, revealed a tiny medallion with a red-jacketed soldier and O'Farrell's ancestor. The discovery sparked O'Farrell's curiosity about her family's history and the history of Ireland. The Impact of the Great Famine The great famine, which occurred between 1846 and 1852, had a devastating impact on Ireland, with over a million people dying of starvation or famine-related disease, and another million forced to emigrate. Fiction as a Tool for Discovery O'Farrell believes that fiction comes from what you don't know, and her book 'Land' is a testament to this. The novel tells the story of a man, Tomás, and his family, striving to emerge from the long shadow of the great famine. A New Perspective O'Farrell's book offers a new perspective on the history of Ireland and the impact of the great famine on families. Her research and writing have shed light on a little-known aspect of her family's history and the history of Ireland.

The Lead: Liverpool at a CrossroadsAs Liverpool prepares for life after Arne Slot, the club faces significant challenges that will define their immediate future. The Dutchman's tenure ended without the dominance expected, leaving a squad in need of strategic overhaul both on and off the pitch. The new manager inherits a team that must rediscover its identity while addressing key personnel departures and tactical shortcomings.Style Evolution: From Heavy Metal to Soft RockPerhaps Mohamed Salah's style of communication wasn't the slickest, but he was correct that Liverpool need to redefine the style of football they play. Everything on the pitch last season under Arne Slot felt very placid as Liverpool failed to dominate opponents and were often found overrun. The new head coach will want to demonstrate his plans and implement an attacking style to best use what is available to him. Anfield does not want to witness back-foot football, fans want to see a swagger to those in red. Supporters and Slot suffered from a disconnect in the final months. The Dutchman was hindered by not possessing the vivacious personality of Jürgen Klopp nor the results in the end, and the aforementioned tedious style. The successor will want to put fans at the forefront and build a strong bond between stands and dugout, built on a platform of attractive play.Investment Analysis: Underperforming Key SigningsAfter spending heavily last summer trying to build a squad capable of dominating the Premier League for years to come, it was difficult to pick out someone who thrived. Hugo Ekitiké was the best of the new arrivals but record signings Florian Wirtz and Alexander Isak barely made the season's footnotes. Isak could at least attribute his struggles to fitness and injury problems, including a leg fracture, but the German's first taste of English football was a sour one. He never looked comfortable as a No 10, physically finding it tough going as speed on the ball and strength in battle were lacking. Getting the best out of a clearly talented player must be a priority, because Wirtz has the capabilities to open defences and help Liverpool control games but needs a confidence boost and an arm around the shoulder.Structural Impact: Midfield Deficiencies and Leadership VacuumWirtz is part of a wider midfield issue that lacks physicality and an obvious No 6. Ryan Gravenberch was elected as the man for the role by Slot, which worked well when the possession stats were in Liverpool's favour but finding someone who can break things up effectively is advisable. Every other team have someone who can break up play but Liverpool lack someone in that role. Not since Georginio Wijnaldum or Fabinho have the club possessed someone capable of overwhelming opponents with their physical attributes and in an evolving sport, this oversight must end. Dominik Szoboszlai being moved around the pitch was unhelpful because he can be one of the best central midfielders in the world but needs a defined position to make his own.The players departing Anfield are weighed down with individual and team trinkets, thanks to the success they have enjoyed with Liverpool. Arguably, the influence of Salah and Andy Robertson on the pitch waned in their final season with the club but their experience and winning mentality will be a huge loss to the dressing room and training ground. Ibrahima Konaté is another exiting, providing a recruitment headache the club were not fully anticipating. It does beg the question if it is the right time to allow Alisson Becker, who has suffered from injury problems in recent times, to be sold and allow a new generation to start afresh, with Virgil van Dijk leading the transition. There are plenty of potential internal candidates who can take on greater responsibility but it may require a change in transfer strategy to acquire players in their late-20s with Champions League experience to help give the right balance.Defensive Rebuild: Addressing Key DeparturesKonaté's contract expiration will be softened by Jérémy Jacquet's impending arrival but further investment is required. Van Dijk's longevity is unknown so finding a partnership for the long term will be critical; a more rugged centre-back like Nottingham Forest's Murillo could be an ideal choice to offer balance and greater aggression. Competition for Milos Kerkez will be important, but if Andoni Iraola does take the job the reunion could get the best out of the Hungarian and get him to flourish after a mixed first year on Merseyside. On the opposite side, continuity would help everyone because Slot was forced to trying numerous people in the role, many out of position. Ideally, Conor Bradley or Jeremie Frimpong can make it their own, having struggled to replace Trent Alexander-Arnold, although both have suffered with injury problems. If they can stay fit, they both possess the quality to be a solution, especially if clever coaching can embrace their attacking prowess and incorporate more defensive discipline.Future Outlook: Rebuilding the AttackSlot insisted that new wingers would change the dynamic next season but he will not be the one to benefit. Salah is off, Federico Chiesa cannot carry on as a bit-part, so will almost certainly leave too, freeing up some space on the flanks. Rio Ngumoha offered brief teenage glimpses of excitement as someone with the pace and trickery to get past full-backs. Frimpong, brought in as a right-back, was more often found on the wing because he possessed the speed Slot desired in those areas, while also offering a further indication that the transfer dealings left a lot to be desired. They did not replace the maverick tendencies of Luis Díaz and Cody Gakpo has never looked a natural winger. Targeting new wide men will be imperative. RB Leipzig's Yan Diomande, Brighton's Yankuba Minteh or Athletic Club's Neco Williams would be ideal candidates to bring thrust to a side lacking dynamism and get supporters off their seats.

The Connection to Nature As a recent study revealed almost half of UK adults now spend less than three hours a week in natural settings such as gardens, parks, fields or woods, we asked readers to tell us about what being outside means to them. Personal Stories of Healing The replies – heartfelt and passionate – came flooding in, with some admitting they just did not have the words to say how important it is. “It’s my happy place, my therapy and a reason to slow down and pause during my busy week,” wrote Hannah Powell from Perrywood garden centres. “I HAVE to look at plants every day. I notice every change in the garden. I sit facing the garden for my breakfast. I look out for nature on the way to work (recently seeing a little owl, red kites, foxes, hares, and more). It helped me get better when I had burnout and FND in London. I wouldn’t (couldn’t) be without it.” The Science Behind Nature's Benefits David Lynch esaid about his love of being outside. “Anxiety levels drop, all worldly concerns are put in perspective and [I] feel younger.” He agreed with others that there was plenty of recent science explaining the health benefits, but added: “I also read about ancient wisdom of Buddhism, which advocates solitary time in nature. All sources uphold the truth that better connection with nature brings better self-awareness and increased sensitivity to the needs of our ecosystem, plus better connection with each other.” The Impact on Mental Health Isabel Romaniw, who is working towards becoming a forest bathing guide, wrote passionately about the basic human need to be outside and to connect with nature. “We are animal, a simultaneously ordinary and yet utterly remarkable part of the great, miraculous tapestry of life on Earth. We have done much to shape our world and influence the fates of almost all other species we share our world with, but we must remember that we are but a tiny chapter, perhaps a footnote, in the ongoing story of the universe, in order to start to heal the damage and repair our relationships with ourselves, with each other, with our other-than-human kin, and with our one precious home.” For Romaniw, as for many others, our disconnection with nature is closely linked to “the worsening physical, mental and spiritual health crises that seem to be going on”. Cherished Memories of Nature Many of you had wonderful memories of times outside. “I was a sickly, pasty, shy, anxious kid,” wrote Mat Jordan. “In the early 70s my parents couldn’t afford to take us to the seaside one year so we went camping in the Peak District instead. It was a revelation. I absolutely loved it. The landscape and dry-stone walls of the white peak are still a favourite, although I spent some years in my 20s living in the Lake District too. One of my favourite memories is driving out of Sheffield into the Peaks with my then baby son to get him to fall asleep and still being awe-struck at the beauty on our doorstep.”

Executive Summary: Scammers Weaponize Antivirus Renewal FearsCybercriminals are sending counterfeit McAfee renewal emails that promise massive discounts and warn that devices are "at risk" if users do not act immediately. The tactic preys on long‑standing consumer anxiety about malware, turning a trusted brand into a conduit for financial fraud.How the Fake McAfee Renewal Email OperatesThe fraudulent messages mimic official branding but contain tell‑tale signs of deception:Urgent language urging immediate payment to secure a 89% discount.Claims that the user's protection will expire, making the device vulnerable.Obscure sender addresses unrelated to the genuine company.Links that either redirect to a fake site or embed malicious URLs alongside legitimate McAfee links to boost credibility.Victims are prompted to enter personal or financial details, which are then harvested by the scammers.Numbers Behind the Scam: Discounts, Victim Costs, and ReachWhile exact loss figures are not disclosed, the following data points illustrate the scale:89% discount offers create a false sense of value, encouraging quick clicks.Similar phishing campaigns have generated millions in fraudulent revenue globally in 2025, with a noticeable uptick in AI‑crafted emails.Reports from McAfee indicate a surge in counterfeit renewal notices across the UK and Europe during the first quarter of 2026.Why This Signals a Growing Threat to Consumer TrustThe scam underscores a broader shift:AI tools enable more convincing spoofed communications, blurring the line between legitimate and fraudulent messages.Consumers increasingly rely on brand reputation for security decisions, making trusted names like McAfee attractive attack vectors.Financial institutions and email providers must adapt their detection mechanisms to counter increasingly sophisticated phishing tactics.Future Outlook: Evolving Tactics and Defensive StrategiesExperts predict that scammers will continue to refine their approach, incorporating personalized data and real‑time threat intelligence to heighten urgency. Users should:Verify any renewal notice directly on the official McAfee.com site, not through email links.Report suspicious messages to the brand and to email providers using built‑in phishing tools.Monitor bank statements for unauthorized charges and report fraud promptly.As AI‑driven phishing matures, ongoing public education and robust authentication measures will be essential to protect consumers from similar scams.

The Partial Internet Restoration Reveals Public AngerThe partial lifting of internet restrictions in Iran has revealed a rising tide of anger about food price inflation as ordinary Iranians decry annual price increases of 308% for vegetable oil, 190% for chicken, and 170% for rice. Iranian authorities began restoring the connection to the global internet that was severed on the first day of the US-Israeli war against the Islamic Republic on 28 February, as it had been during mass protests in January.Connectivity Remains Limited Despite Partial RestorationConnectivity remained patchy on Wednesday, with mobile internet still largely disconnected and many sites remaining restricted. But even the partial restoration was enough to reveal an outpouring of anger over price inflation and food shortages. "Everything is so expensive. It has become a disaster," wrote one user on social media. "You leave the market with a broken heart after spending all your savings. It is unbearable. We have no patience left to lead a normal life."Government Response and Blame-ShiftingPresident Masoud Pezeshkian, who has been given some credit for lifting the internet restrictions, blamed the US for Iran's economic woes, saying Washington "had moved to economic warfare after failing to bring the government down." In a lengthy statement, the ministry of intelligence revealed its concerns that internet freedom could be used for "cognitive warfare", warning that Iran's adversaries aimed to "incite protesters and drag them on to the streets."Hyperinflation Data Reveals Economic CrisisThe government announced the launch of a "resistance economy committee" to crack down on price gouging and address surging shortages, but hyperinflation is now endemic in Iran owing to trade sanctions, exchange rate pressure, and moves taken to reduce subsidies given to traders in January. Data from the International Monetary Fund showed food inflation had risen to between 140% and 200%, pushing overall inflation to 70%. Support for continuing internet restrictions was put at just 9% in a survey published on Wednesday.Government Propaganda and Public ResponseIn an attempt to forestall support for Reza Pahlavi, the son of the late shah, government backers tried to flood the internet with claims directed at "youngsters returning to the internet" that Pahlavi had openly applauded the attacks mounted by Israel and the US. Others expressed simple relief that they could now talk to the wider world. The human rights activist Emadeddin Baghi wrote: "Three bloody months have passed, but not for those who lost a loved one or had their home destroyed. In this period our voices found no echo except on some internal platforms and to the best of our ability we spoke and wrote in defence of the rights of the voiceless."Future Outlook: Digital Rights and Economic InstabilityThe prominent rapper Toomaj Salehi, who was sentenced to death in 2024 for supporting protests in 2022 but was later released, said being connected to the internet was "not a favour to us – it is our right. And without filters as well. Like free elections, freedom of expression, freedom of assembly, freedom of parties, and many other freedoms, these are our rights and not favours," he wrote on X. With public sentiment increasingly turning against the government and economic conditions worsening, Iran faces a precarious future balancing between maintaining control and addressing growing public discontent.