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Coordinated strikes by United States and Israeli forces hit Tehran, Isfahan and several other Iranian cities on Tuesday, prompting widespread power outages and extensive damage to civilian sites. The Ministry of Energy confirmed that shrapnel from the raids ruptured a primary power‑transfer line, but the outage was restored within a few hours. Among the most critical targets was the Tofigh Darou pharmaceutical complex in the Karaj industrial zone. The facility, which supplies over 90% of Iran’s domestically produced medicines—including cancer and multiple‑sclerosis treatments—sustained heavy damage from multiple projectiles. In central Iran, Isfahan endured a barrage of heavy bunker‑buster bombs over a nearby mountainous area, likely aimed at military installations. The explosions triggered secondary blasts that illuminated the night sky and produced reverberating shockwaves across the city. North‑west of Tehran, in Zanjan, a building identified as the administrative department of the Hosseinieh Azam religious centre was struck, resulting in at least four fatalities and several injuries. Iranian authorities now claim that more than 2,000 people have been killed by US‑Israeli attacks since the conflict erupted on 28 February, with residential blocks, schools, hospitals and historic sites also affected. Additional targets this week included civilian nuclear facilities, major steel producers, petrochemical plants, and the Iran University of Science and Technology, where an imaging satellite was developed. A professor linked to Iran’s missile programme and his two children were assassinated at their home in northern Tehran. U.S. President Donald Trump reiterated threats to strike Iran’s oil and gas infrastructure, power plants and water‑desalination facilities. Despite the onslaught, the Islamic Revolutionary Guard Corps (IRGC) continues to project defiance. A spokesperson for the Khatam al‑Anbiya Central Headquarters declared that Tehran’s adversaries are “humiliated and on the path of destruction,” while senior commander Ali Fadavi warned that American warships are vulnerable and allegedly transmit false transponder signals. The IRGC also released footage of ballistic missiles aimed at Israel and surrounding nations, and claimed to have downed two U.S. MQ‑9 Reaper drones, promising retaliatory strikes against technology firms linked to the United States and Israel. Domestically, the judiciary announced the execution of two members of the foreign‑based Mojahedin‑e‑Khalq (MEK) group, labeling them terrorists. This follows a series of recent executions tied to the January protests and broader dissent. Authorities also issued new indictments against roughly 200 individuals accused of assisting the U.S. and Israel, including alleged “mercenaries” who disseminated strike footage abroad. Penalties for national‑security offenses now encompass asset confiscation and capital punishment. President Masoud Pezeshkian convened his first cabinet meeting since the war’s onset in a makeshift, blue‑covered space, emphasizing that any peace negotiations will safeguard Iran’s “dignity, security and national interests.” Israel’s Channel 14 reported that Pezeshkian sought greater negotiating leverage with the United States, a request allegedly rebuffed by IRGC chief Ahmad Vahidi.

Israeli and U.S. forces launched a series of air strikes on Tuesday that struck Tofigh Daru Research and Engineering Company, one of Tehran’s largest producers of anaesthetics and anti‑cancer medicines. The state‑run firm, owned by the Social Security Investment Company, saw its drug‑production line damaged, according to an official post on X. In the north‑western city of Zanjan, a separate strike hit the Husseiniya Azam, a Shia congregation hall adjacent to a mosque. Iranian Red Crescent teams rescued two people from the rubble; one of the victims died and several others were injured. Further attacks were reported in the western province of Kermanshah, where a civilian contracting company in Qasr‑e Shirin – a border town with Iraq – was hit. One person was killed and eight injured, the Mehr news agency said. Heavy bombing was also confirmed in Isfahan, a strategic hub for Iran’s defence industry and home to key nuclear facilities such as Natanz. Local officials indicated that the strikes may have targeted “military sites,” though the exact locations and damage assessments remain unclear. Iranian officials condemned the operations. Former foreign minister Javad Zarif denounced the targeting of the pharmaceutical plant as a deliberate attack on a medical facility, calling the aggressors “desperate” and accusing them of “diabolical delusions.” Governor‑level security official Akbar Salehi echoed these concerns, noting that the strikes appeared aimed at military installations without specifying which ones. The broader conflict has already claimed 1,937 Iranian lives since the joint U.S.–Israeli campaign began on 28 February, while 20 Israelis have been killed. Recent Israeli interceptions using the Iron Dome and David’s Sling systems have limited damage on Israeli soil, but impact sites were reported in Tel Aviv, Bnei Brak and Petah Tikva. Amid the escalating violence, diplomatic channels remain active. U.S. Secretary of State Marco Rubio told Al Jazeera that communications between Washington and Tehran continue, primarily through intermediaries, and that the U.S. aims to achieve its war objectives “in weeks, not months.” Pentagon chief Pete Hegseth added that negotiations to end the conflict are “very real, ongoing and gaining strength.” Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed a retaliatory strike, saying it hit an Israeli container ship in the Gulf with a ballistic missile and that Iranian drones targeted a group of U.S. Marines near a UAE military base. Public sentiment in Iran has turned sharply hostile, with pro‑state demonstrations erupting in Tehran as citizens protest the continued air raids. The atmosphere, described by Al Jazeera’s Tohid Asadi as a “cloud of mistrust,” reflects growing frustration over diplomatic dead‑ends and the relentless cycle of attacks.

Palantir’s senior UK representative has warned ministers against yielding to ideologically motivated campaigners as they explore the possibility of terminating a £330 million NHS contract for the company’s Federated Data Platform (FDP).The FDP, an AI‑enabled system intended to unify patient information across the health service, is part of a broader portfolio that includes contracts with the Ministry of Defence, several police forces and the UK’s financial regulator.Louis Mosley, executive vice‑chair of Palantir UK, told The Times that abandoning the deal would jeopardise patient care and hinder progress on the NHS’s most pressing challenges. He highlighted that the platform is projected to generate £150 million in benefits by the end of the decade, delivering a £5 return for every pound spent.According to the Financial Times, senior officials have begun informal discussions about activating a break clause that would allow the FDP’s operation to be transferred to an alternative provider once the system becomes fully operational next year.Palantir, a US‑based data‑analytics firm with ties to the Israeli and US militaries and former U.S. Immigration and Customs Enforcement contracts, has faced sustained opposition from the British Medical Association, which has long criticised the use of its technology in patient‑care settings.Health officials acknowledge the reputational risk, noting that the controversy now extends beyond traditional Labour‑left and Green Party critics. A Department of Health and Social Care spokesperson emphasised that the FDP is designed to improve care coordination, accelerate cancer diagnoses and increase treatment capacity, while maintaining strict data‑security safeguards.Health Secretary Wes Streeting, speaking on the Guardian Politics Weekly podcast, recognised public unease about Palantir’s political affiliations, referencing founder Peter Thiel’s right‑wing connections. He reassured listeners that Palantir does not have direct access to patient data, stating, "The platform is operated by us; Palantir never sees the data."Adoption of Palantir’s technology within the NHS has risen from 118 to 151 organisations since June, though it remains short of the government’s target of 240 organisations by year‑end. Labour backbencher Clive Lewis noted that the issue is becoming a visible concern for voters, reflecting broader anxieties about AI and foreign‑owned infrastructure in critical public services.

In Mexico, a mother's determination to navigate the country's beleaguered cancer care system has become a defining feature of her daily life. Faced with a healthcare system in crisis, she finds herself unceasingly vigilant in her quest for adequate treatment.The situation in Mexico's healthcare sector is marked by significant challenges, particularly in the realm of cancer care. Patients and families are often left to struggle with accessing timely and effective treatment, leading to a heavy emotional and financial toll.For this mother, the reality of her child's health battle is a harsh reminder of the system's shortcomings. Her story serves as a poignant example of the human cost of healthcare deficiencies and the resilience of those affected.

Tim Sweeney, the CEO of Epic Games, the company behind the popular online game Fortnite, has issued an apology after facing backlash for laying off an employee with terminal brain cancer. The layoff not only resulted in the loss of income for the employee's family but also meant they would lose their life insurance. The controversy began when Jenni Griffin, the wife of Mike Prinke, a laid-off employee, shared their story on social media. She revealed that her husband was fighting terminal brain cancer and that the layoff meant they would lose his life insurance. Griffin expressed her concerns about the financial burden they would face, including the cost of a funeral and burial. Sweeney responded to Griffin's post, apologizing for not recognizing the situation earlier and promising that Epic Games would solve the insurance issue for the family. He stated that the company would provide a solution to ensure the family receives the necessary support. Epic Games announced the mass layoffs on March 24, citing a downturn in Fortnite engagement and a need to make major cuts to keep the company funded. Sweeney justified the layoffs by saying that the company was spending significantly more than it was making. Affected employees were offered a severance package, including at least four months of base pay, along with other benefits tied to tenure at the company. The layoffs have sparked controversy, with many questioning the decision to let go of over 1,000 employees despite the company's annual profits of $4 billion. Fortnite is the world's fourth most-played PC game, and the company's financial situation has raised concerns about the impact of the layoffs on employees and their families. Griffin's post, which included a picture of her husband's brain scan, quickly went viral, prompting Sweeney to respond and offer support to the family. The incident has highlighted the human impact of corporate decisions and the need for companies to consider the well-being of their employees.

A groundbreaking analysis has revealed that 37% of conventional California produce contains toxic Pfas pesticide residues. The Environmental Working Group (EWG) conducted the study, which coincided with the introduction of California legislation aimed at banning Pfas from being used as active ingredients in pesticides by 2035.The analysis of California department of pesticide regulation residue testing records found that about 90% of peaches, plums, and nectarines contained Pfas residues, while 80% of strawberries and grapes showed contamination. These findings are particularly alarming as children are most at risk from the toxic effects of Pfas, and commonly eat fruits like grapes and strawberries.Pfas are a class of at least 16,000 compounds used to make products resistant to water, stains, and heat. They are called "forever chemicals" because they do not naturally break down and accumulate, and are linked to cancer, kidney disease, liver problems, immune disorders, birth defects, and other serious health problems.The EWG analyzed records for 930 samples across 78 types of non-organic, California-grown fruits and vegetables. The results showed that 348 samples, or 37%, contained Pfas residues, with at least half of all produce varieties treated with Pfas pesticides.The proposed legislation in California would ban the use of Pfas as an active ingredient in pesticides by 2035 and place a moratorium on approvals of new Pfas pesticides. The bill's author, California assemblymember Nick Schultz, stated that he doesn't want his kids "eating strawberries contaminated with chemicals that will stay in their bodies for decades."The pesticide industry is expected to mount a strong campaign against the legislation, but Maine and Minnesota have already passed similar bans, making it more likely to pass in California.

For the first time, a team of researchers has successfully mapped out the intricate network of nerves within the clitoris, a crucial organ responsible for female sexual pleasure. This achievement comes almost 30 years after a similar mapping was completed for the penis. The 3D scans of two female pelvises, donated through a body donor program, have provided unprecedented detail on the five complex tree-like branching nerves running through the clitoris. The widest of these nerves measures 0.7mm across. Led by Ju Young Lee, a research associate at Amsterdam University Medical Center, the study challenges existing knowledge about the anatomy of the clitoris. For instance, previous research suggested that the dorsal nerve of the clitoris diminished as it approached the glans, but the new scans show that it continues strongly to the end. The clitoris, one of the least-studied organs in the human body, has been neglected by researchers for far too long, according to Melbourne urologist Helen O'Connell. She notes that cultural taboos around female sexuality have hindered scientific investigations, and it wasn't until 1995 that the clitoris was included in standard anatomy textbooks. The mapping of clitoral nerves is expected to inform reconstructive surgery after female genital mutilation, which affects over 230 million girls and women worldwide. A better understanding of the nerve pathways could reduce the number of women who experience a decline in orgasmic experience after surgery. This breakthrough also has implications for vulvar cancer treatment, gender reassignment surgery, and genital cosmetic surgeries. As Lee hopes to open a clitoris exhibition to expand knowledge about the organ, inspired by the Vagina Museum in London, the study marks a significant step forward in understanding female sexual function and anatomy.

Walking into Scisters Salon & Apothecary in southern California reveals what's immediately absent: no wall of plastic bottles, no chemical tang, and minimal waste. The salon's shelves feature large refill containers of shampoo and conditioner, houseplants adorn the space, and hair clippings are composted. The only trash can is a small basket mostly collecting clients' personal items, creating an environment that co-owner Melissa Parker notes clients immediately comment on: 'It smells good in here.' That never happens in a conventional salon.Opened 15 years ago by Parker and Easton Bajsec in La Mesa near San Diego, Scisters has evolved into one of the region's most prominent low-waste salons, diverting up to 99% of its refuse from landfills. Their business transformation addresses a significant industry problem: the beauty sector generates substantial waste, with North American salons sending an estimated 63,000lbs of hair to landfills daily, plus hundreds of tons of used foil and leftover hair dyes.The turning point came when Bajsec watched a documentary about the zero-waste movement while Parker developed health problems linked to prolonged exposure to salon chemicals. Studies have found that hairdressers' exposure to harmful chemicals such as formaldehyde, ammonia and sulfates puts them at higher risk of asthma, skin conditions, reproductive illnesses and cancer. Rather than leave the industry, they transformed their business.They eliminated perms due to formaldehyde exposure and moved away from big-name products despite green marketing claims. When existing alternatives didn't meet their standards for performance, ingredient transparency and waste reduction, they created their own line. Element, launched in 2019, is made in a California lab and sold in refillable glass and aluminum containers, featuring recognizable ingredients like organic aloe, wheat protein and castor oil.The salon's waste reduction strategies extend beyond product packaging. They implemented hair composting, foil recycling, and replaced waxing with sugaring—a compostable hair-removal technique. They switched to LED lighting, installed water-efficient showerheads, and use washable cloths instead of paper towels. Though they still offer hair bleaching (which releases ammonia), they mitigate risks with industrial air filtration and air-purifying plants.Bajsec acknowledges that 100% zero waste is impossible due to regulatory constraints on reusable gloves and plastic pump tops. The salon ships its minimal plastic waste to Green Circle Salons for specialized processing, paying $200 per box. Despite this cost, Parker notes the overall approach has been financially beneficial: 'Overall, it's actually less expensive. We're not outsourcing to other beauty brands. We're mindful about systems.'Their commitment to sustainability proved critical during the COVID-19 pandemic. When mandatory closures threatened their survival, they pivoted to refill sales, meeting clients in the parking lot. This refill model kept revenue flowing, allowing them to pay full rent while many neighboring tenants struggled. 'Going green has been the greatest thing we've done for our business financially,' Parker says. 'We accidentally created a point of differentiation.'Denise Baden, a professor of sustainable business at the University of Southampton, confirms that eco-friendly practices often reduce costs. 'It's a misunderstanding that to be eco-friendly, you have to spend more money. In fact, usually, it's the reverse,' she notes, adding that hairdressers are uniquely positioned to influence their communities.Now, Parker and Bajsec are helping other salons adopt similar practices through speaking engagements and an online guide. 'We get calls from other salons all the time,' Bajsec says. 'It's not sustainable if we're the only ones doing it.'

A recent conversation with a guest at an academic function brought to light the public's desire for a simple, all-encompassing test for cancer. The guest, intrigued by the speaker's profession as an oncologist, inquired about the existence of an 'everything' test for cancer. The speaker's response was clear: no such test exists.The quest for early cancer detection is a significant goal in cancer medicine, with the aim of identifying the disease before it metastasizes and ensuring a cure. One company, Grail, launched a blood test called Galleri, which claims to detect a 'signal' shared by more than 50 types of cancer. This signal is identified through circulating DNA, minute fragments of cancer DNA present in the bloodstream.The Galleri test was marketed as a screening tool, with results indicating either a cancer signal detected or no cancer signal detected. However, the test failed to meet its primary endpoint in a large-scale trial conducted with the NHS, which aimed to determine if the test could reduce late-stage cancer diagnoses. Despite the company's claims of 'strong' results, the trial did not demonstrate a significant reduction in late-stage cancer diagnoses.The failure of the Galleri test highlights a crucial distinction between detecting more cancers and saving lives. Detecting cancer at an early stage does not necessarily translate to less invasive treatments or prolonged survival. Moreover, some cancers detected through screening may never have posed a lethal threat, leading to unnecessary interventions.For now, there is no blood test or total body scan that saves lives. Instead, the focus should be on modifying cancer risk factors, such as reducing processed foods, curbing alcohol consumption, quitting smoking, and engaging in regular exercise. These evidence-based approaches may not be as flashy as a single 'everything' test, but they have a proven impact on public health.