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The chief executive of Stack BTC, a bitcoin company promoted by Nigel Farage, has departed as the venture seeks to assure investors of its potential for long-term value. Stack BTC was launched earlier this year with significant fanfare, counting Farage and former chancellor Kwasi Kwarteng among its initial shareholders.The company, originally founded in 2021 by Jai Patel under the name Kasei Investment Holdings, has undergone a rebranding. Its aim is to encourage investments in cryptocurrencies, particularly targeting individuals over 45. However, its previous iteration, Kasei, faced liquidation last year due to adverse market conditions and an inability to raise further capital.Stack BTC's strategy involves accumulating bitcoin and operating as a venture capital firm, investing in smaller companies and reinvesting revenue in bitcoin. The company's share price is expected to correlate with the price of bitcoin. Farage invested £215,000 in the company, and on paper, the value of his stake appears to have increased by more than £200,000.Jai Patel's departure was announced on Wednesday, with the company stating that the move is part of efforts to strengthen the executive team and deliver long-term value for shareholders. Patel has been replaced by David Galan, a former real estate executive with experience in capital markets and mergers & acquisitions.CryptoUK's Ian Taylor expressed skepticism about the company's prospects, suggesting that the involvement of Farage and Kwarteng may deter potential investors. Taylor noted that the company's approach appears to be a PR branding exercise rather than a genuine investment opportunity.

A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Sudan, one of the world's most impoverished countries, has been ravaged by a civil war that began in 2023. The conflict, driven by a power struggle between the army and the paramilitary Rapid Support Forces (RSF), has left the nation unrecognizable. Over 40,000 people have been killed, and about 14 million – a quarter of the population – have been forced to flee their homes. Civilian infrastructure across the country has been extensively damaged.“We are not just facing a crisis – we are witnessing the systematic erosion of a country’s future,” Luca Renda, the United Nations Development Programme’s (UNDP’s) resident representative in Sudan, told Al Jazeera. A report by the UNDP and the Institute for Security Studies highlights the scale of Sudan’s economic collapse. Even under the most optimistic scenario of peace being achieved in 2026, Sudan would still lose an estimated $18.8 billion in gross domestic product (GDP) by 2043.The war has had a devastating impact on Sudan's infrastructure and basic services. $6.4 billion was lost in GDP in 2023 alone, reflecting a simultaneous collapse across all major parts of Sudan’s economy. The destruction of infrastructure has triggered displacement and made it difficult for people to secure adequate housing or access basic services. Up to 40 percent of power generation capacity has been lost, and key water infrastructure has been destroyed or seized, cutting communities off from clean water and sanitation.The labor market has also been severely affected, with agriculture – once the backbone of Sudan’s economy – severely hit. Cultivated land has shrunk, adversely impacting rural livelihoods. Average incomes have fallen back to levels last seen in 1992. About 90 percent of manufacturing activity has been destroyed in key economic hubs, eliminating thousands of jobs.The oil industry has suffered significantly, with oil output falling amid widespread instability and infrastructure damage. The Khartoum refinery, which previously processed up to 100,000 barrels per day, has been out of operation since July 2023. Key infrastructure, including pipeline routes carrying crude to Port Sudan, has been hit.The collapse of the Sudanese pound and supply chains has caused a sharp rise in living costs. Food prices have surged, with four pieces of bread now costing about 1,000 pounds, an amount that had previously bought six pieces. Wages have failed to catch up with inflation, leaving many households without access to necessities. Nearly half the population is now experiencing acute food shortages.The economic collapse has had a profound impact on Sudan's people, with 34 million people in need of assistance and 19 million facing acute food shortages. The war has caused death, trauma, and profound loss, casting a long shadow over Sudan’s future and dimming the prospects of a generation whose lives are being shaped by violence. If the conflict continues to 2030, Sudan’s economy in 2043 would be about $34.5 billion smaller than it would have been without the war, and GDP per capita would drop by roughly $1,700.

Iranian Major General Ali Abdollahi stated that if the US continues its naval blockade in the Strait of Hormuz, it would be seen as a prelude to violating the ceasefire. The blockade has completely halted economic trade going into and out of Iran by sea. Abdollahi emphasized that Iran's armed forces will not allow any exports or imports to continue in the Persian Gulf, the Sea of Oman, and the Red Sea. The US military's actions have significant implications for Iran's economy and regional stability.The current ceasefire was declared a week ago, and US President Donald Trump hinted at a second round of face-to-face talks with Iran in Pakistan in the coming days. However, Iranian authorities have maintained a defiant approach, with parliament's deputy speaker, Ali Nikzad, stating that Iran will never give concessions to its enemy.Iran's Ministry of Foreign Affairs spokesman, Esmaeil Baghaei, emphasized that Iran has not and will not seek a nuclear weapon but insists on its right to pursue nuclear energy for civilian purposes under United Nations safeguards. The level and type of enrichment can be negotiated.Iranian authorities have continued to announce the enforcement of death sentences, as well as a large number of arrests and asset confiscations. The judiciary has said some of the executions were linked to nationwide protests in January, during which thousands of people were killed during an internet blackout.

Washington, D.C. – The U.S. Senate voted 47‑52 to reject a resolution that would have limited President Donald Trump’s power to wage war against Iran, marking the fourth defeat of the measure despite weekly attempts by lawmakers. The vote follows a two‑week ceasefire agreed upon last week, though subsequent negotiations in Islamabad failed to produce a longer‑term deal. Both sides have indicated openness to a second round of talks. President Trump’s earlier threats, including a statement on April 7 that a “whole civilisation will die tonight,” intensified congressional calls for constraints on his war‑making authority. Party lines largely dictated the outcome: Republican Rand Paul voted in favor, while Democrat John Fetterman broke with his party to oppose the resolution. Supporters argue that Trump acted beyond constitutional limits when he joined Israel in launching the February 28 offensive. The U.S. Constitution reserves the declaration of war for Congress, allowing presidents to act unilaterally only in cases of immediate self‑defence. Senator Chris Murphy, speaking before the vote, described the conflict as a “bungled, mismanaged war” that has failed to meet the administration’s objectives. He criticized the lack of transparency and oversight, noting that the war is costing “billions of dollars every week,” has claimed “over a dozen American lives,” and is destabilising economies worldwide. Republican Senator Jim Risch defended Trump’s actions, dismissing the resolution as “same old, same old” and asserting that the president has both the right and duty to act. The House of Representatives is slated to consider its own war‑powers resolution this week, with a higher likelihood of passage given growing wariness among some Republicans. Even if both chambers approved the measure, Trump could veto it, requiring a two‑thirds supermajority to override. Under the War Powers Act of 1973, Congress must either authorize the military action or approve a 30‑day extension when the conflict reaches its 60‑day mark at the end of April. Failure to do so would legally compel the president to begin withdrawing forces. U.S. blockade updates: U.S. Central Command reported that no vessels have successfully breached the blockade of Iranian ports in the Strait of Hormuz over the past 48 hours, with nine ships complying with orders to turn back. The U.S. Navy warned that vessels attempting to transit will be boarded for interdiction and seizure. Treasury Secretary Scott Bessent announced a forthcoming set of financial measures described as the “financial equivalent” of military attacks, while noting that some sanctions had been lifted to ease soaring global energy prices. White House spokesperson Karoline Leavitt said the administration has not formally requested an extension of the ceasefire, which is set to expire next week, but expressed optimism about a second round of talks in Islamabad. Iran’s state‑run television reported that a high‑level Pakistani delegation arrived in Tehran to coordinate new negotiations. Meanwhile, Major‑General Ali Abdollahi of the IRGC warned that the ongoing naval blockade could jeopardise the fragile ceasefire, describing it as a “prelude to a violation of the ceasefire.”

President Donald Trump declared that the war with Iran is "very close to over," even as Washington maintains a naval blockade of the strategic Strait of Hormuz. In Washington, D.C., Israeli and Lebanese ambassadors convened for uncommon direct talks, seeking a cease‑fire while Israel pressed for Hezbollah’s disarmament. Trump also hinted at a possible second round of negotiations with Tehran, suggesting talks could resume in Pakistan within days. The United States, however, is set to let a temporary sanctions waiver on stranded Iranian oil expire, tightening economic pressure on Tehran. The International Committee of the Red Cross and Red Crescent Societies delivered its first shipment of medical supplies and humanitarian aid into Iran since hostilities began, offering a modest lifeline to civilians. Inside Tehran, minor explosions caused limited damage and injuries, underscoring ongoing instability. Iran estimates its war‑related losses at $270 billion and plans to seek reparations. On the diplomatic front, the United Nations' IAEA chief Rafael Grossi noted that the duration of any uranium‑enrichment moratorium would be a political decision, reflecting the delicate balance of future negotiations. In the United States, the Senate is poised to vote as early as Wednesday on a Democratic initiative to restrict the president’s war powers, signaling growing congressional scrutiny of the conflict. Former defence official David Sedney warned that the Hormuz blockade is backfiring, increasing pressure on Washington as global trade routes are disrupted and domestic support wanes. Meanwhile, CENTCOM Commander Admiral Brad Cooper affirmed that the blockade of Iranian ports is fully operational and that U.S. forces retain maritime superiority in the region. President Trump publicly rebuked Italy’s Prime Minister Giorgia Meloni for not joining U.S. actions against Iran, describing her stance as lacking courage. U.S. Treasury Secretary Scott Bessent announced that American forces will intercept Chinese tankers carrying Iranian oil through the Hormuz Strait, effectively cutting off Iran’s oil exports while allowing non‑Iranian cargo to pass. Israel has proposed a long‑term troop presence extending up to 8 km into southern Lebanon until Hezbollah is dismantled, and continues air strikes aimed at encircling the strategic town of Bint Jbeil. Former U.S. Assistant Secretary of State Jeffrey Feltman highlighted a growing divergence between U.S. and Israeli priorities, noting Israel’s heightened concern over Iran’s ballistic‑missile program. In Lebanon, Israeli raids have resulted in multiple civilian casualties, with reports of villages being razed in a manner likened to Gaza. Hezbollah has rejected the ongoing Israel‑Lebanon talks, while public opinion remains split between hopes for peace and opposition to negotiations. The International Monetary Fund warned that any further escalation could push the global economy toward recession. It cut its 2026 growth forecast for the Middle East and North Africa to 1.1 % from 3.9 %, citing disruptions to Gulf oil and gas exports. On the markets, stock indices rose while oil prices slipped, reflecting renewed optimism for a diplomatic resolution and the reopening of the Hormuz Strait.

Tehran has issued an uncompromising demand for $270 billion in reparations for the devastation wrought by United States and Israeli strikes since the war began on 28 February. The figure, disclosed by government spokeswoman Fatemeh Mohajerani in an interview with Russia’s RIA Novosti, aggregates both direct and indirect losses across a wide range of sectors. Iran’s UN envoy asserted that five regional states must contribute to the compensation, alleging that their territories served as launchpads for attacks on Iranian soil. In parallel, Tehran floated a Strait of Hormuz protocol that would levy a tax on vessels transiting the strategic waterway, earmarking the proceeds for reconstruction. The war has battered Iran’s critical infrastructure: oil and gas complexes, petrochemical plants, steel and aluminium factories, as well as military installations have been repeatedly struck. Damage extends to bridges, ports, railways, universities, research centres, power stations and desalination plants, while countless hospitals, schools and civilian homes have been either damaged or razed. In the aviation sector, Maghsoud Asadi Samani, secretary of the Association of Iranian Airlines, reported that 60 civilian aircraft have been rendered inoperable, with 20 completely destroyed. Iran now operates roughly 160 passenger planes, many of which are decades old and suffer from parts shortages due to stringent US sanctions. The airline industry estimates losses exceeding 300 trillion rials (≈ $190 million) over just 40 days of conflict, compounded by the loss of anticipated revenue from the Nowruz holiday period. Despite the extensive damage, Iranian officials have signalled no willingness to make major concessions in forthcoming negotiations with Washington, including on nuclear enrichment. Hard‑line parliament spokesman Ebrahim Rezaei warned that extending the recent two‑week ceasefire would merely allow the US and Israel to replenish their arsenals, urging the United States to either recognise Iran’s rights—particularly over the Strait of Hormuz—or return to hostilities. Financially, Iran allocated close to $8 billion to its military in 2024, according to SIPRI, and has pledged to triple that budget following previous missile exchanges with Israel. Yet the economy remains strained by years of sanctions, mismanagement and corruption. Compounding the economic strain, the government‑imposed near‑total internet shutdown—affecting over 90 million users—has been estimated to cost the nation up to $80 million per day. Afshin Kolahi of the Iran Chamber of Commerce warned that the blackout equates to losing the output of four B1‑class bridges and two medium‑capacity power plants each day. While a limited “Internet Pro” service is being offered to select users, the majority of the population remains confined to a state‑controlled intranet, prompting widespread calls for internet freedom. These intertwined military, economic and digital pressures underscore the high stakes of the anticipated US‑Iran talks, with Tehran demanding acknowledgment of its losses and a pathway to rebuild a war‑torn nation.

Israeli military forces have launched a series of strikes across the Gaza Strip, resulting in the deaths of at least 11 Palestinians, including two children, a three-year-old and a 14-year-old. These attacks occurred despite a ceasefire agreement between Israel and Hamas that came into effect on October 10 last year.The violence escalated in the northern part of the Gaza enclave on Tuesday, with Gaza's Civil Defence authorities and the Reuters news agency confirming the deaths. Mahmoud Basal, spokesman for Gaza's Civil Defence, reported that four people were killed, including the three-year-old, in a strike targeting a police vehicle in Gaza City. The Ministry of Interior stated that Israeli warplanes had targeted the police vehicle, causing several deaths and injuries, with a police officer among those killed and at least nine bystanders wounded, some critically.Further violence was reported in the northern Beit Lahiya area, where another person was killed by Israeli fire earlier in the day. Later on Tuesday evening, Civil Defence reported that another Israeli strike killed several people near an intersection in the Shati refugee camp in Gaza City. Medics at Al-Shifa Hospital confirmed receiving five bodies from an Israeli drone bombing involving two missiles that hit a group of people in the Shati refugee camp.Despite the ceasefire, Israeli forces continue to carry out daily strikes on Gaza, resulting in almost 760 Palestinians killed since the truce was agreed upon. The Gaza Ministry of Health reported that an additional 2,111 Palestinians have been injured in Israeli attacks since the ceasefire was announced, while a total of 72,336 people have been killed by Israeli forces since the start of Israel's war on the territory on October 7, 2023.

Gray whales have historically been a rare sight in the San Francisco Bay. They migrate over 10,000 miles from Mexico's Baja California to the Arctic region, seldom stopping in the busy shipping corridor for prolonged periods. However, in recent years, this has changed in a dire way.A new study published in the journal Frontiers in Marine Science has found that gray whales in the bay have been dying at alarming rates, largely due to collisions with vessels. Eastern North Pacific (ENP) gray whales began to appear more frequently in the well-trafficked maritime corridor around 2018.According to researchers, at least 18% of gray whales that entered the bay from 2018 to 2025 have died. They determined that for more than 40% of the whale carcasses, the cause of death was blunt force trauma consistent with vessel strikes, prompting calls for renewed efforts to help avoid more fatal collisions.“It was historically very unusual for them to enter the bay, especially for longer amounts of time or consistently year after year,” said Josie Slaathaug, lead author of the study. There are whale subgroups known to hunt for food south of the Arctic, but a majority of the recently spotted whales feeding in the bay were not a part of these foraging clusters.A wave of new whale presence had not been observed in the waters since the late 1990s. Researchers have theorized that Arctic warming is disrupting food availability for the whales, driving them to hunt in new places such as the bay, although it remains unclear what exactly they may be eating there.Their potential new feeding corner, though, is a major shipping route. The true mortality rate for whales in the bay may be higher, hovering somewhere from 40% to 50%, Slaathaug said.In recent years, there have been several reports of dead whales that wash up on Bay Area beaches. The ENP gray whale population has been in decline due to malnutrition and starvation from climate-driven prey shifts in the Arctic. The Southwest Fisheries Science Center estimated a population total of about 13,000 whales, its lowest count since 1970.“It’s not unique to their migratory corridor that a lot of whales are dying,” Slaathaug said. “What is unique about San Francisco Bay and this study was that there was such a clear emerging cause of death.”Some local efforts are under way to reduce vessel collisions. The Marine Mammal Center has developed a program called Whale Smart, to educate vessel operators in the San Francisco Bay on how to interpret whale behavior to avoid close encounters.In Alaska, where vessels also pose a threat to the whale population, one fleet company partnered with WhaleSpotter, a company that uses AI and thermal imaging to detect the presence of whales, so they can change course well in advance.Last year, the Center for Biological Diversity, a conservation group, sued the US Coast Guard, which regulates vessel traffic off the California coast, for failing to analyze how vessel routes may harm whales and sea turtles.“This most recent study about the gray whales reaffirms that we have way underestimated the problem and we are not managing human activities well enough to avoid the whales,” said Catherine Kilduff, senior attorney at the center.Federal action is needed to reduce the fatal collisions, Kilduff said. According to the Endangered Species Act, the coast guard should be consulting with the National Marine Fisheries Service when setting shipping lanes to assess impact to marine wildlife.Kilduff also suggested mandatory speed limits for vessels. “There are voluntary speed reductions on the west coast, but there is evidence that those aren’t effective. The compliance rate isn’t high enough,” she said.A 2022 study co-authored by the National Oceanic and Atmospheric Administration found that the average speeds of large vessels had decreased from 2010 to 2019 in voluntary speed reduction zones. But, researchers determined that the cooperation rate of roughly 50% was lower than the amount needed to reduce vessel strike-related mortality to a level that maintains a sustainable whale population.“These whales are using the oceans in such a sophisticated way. We can learn so much from them, and if we can figure out ways to avoid killing them, I know that they’ll come back to healthy population levels,” Kilduff said.