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As the clock ticked down to President Donald Trump’s 8 p.m. deadline to force the reopening of the Strait of Hormuz, the six‑week Middle East conflict teetered on the brink of a far more devastating escalation.Trump’s rhetoric had escalated dramatically, with his Truth Social posts warning that the United States would unleash strikes capable of “decimating every bridge and power plant in Iran” and that “a whole civilisation will die tonight.” Legal experts labeled the language as bordering on a genocidal threat.Amid the rising tension, a series of rapid developments unfolded on Tuesday:12:06 GMT – Trump announced a plan to target Iran’s civilian infrastructure, promising total destruction of bridges and power facilities.15:21 GMT – Iranian media confirmed that US strikes hit Kharg Island, the nation’s primary oil‑export hub, but reported no significant damage.15:40 GMT – In the UN Security Council, China and Russia vetoed a Bahraini resolution aimed at protecting commercial shipping in the Strait of Hormuz, arguing the draft was biased against Tehran.16:54 GMT – Qatar’s defence ministry reported a successful missile interception, while the United Arab Emirates warned of a barrage of missile and drone attacks.18:23 GMT – Iran’s envoy to Pakistan, Reza Amiri Moghadam, signalled a “step forward” after a “critical, sensitive stage,” praising Pakistan’s “positive and productive” peace efforts.19:17 GMT – Pakistani Prime Minister Shehbaz Sharif appealed to Trump to extend the deadline by two weeks, urging Tehran to keep the Strait open as a goodwill gesture.20:25 GMT – Iran warned it would target US and Gulf‑allied energy infrastructure, threatening to block regional oil and gas supplies for years.20:41 GMT – Joint US‑Israeli airstrikes struck the Amirkabir Petrochemical Plant in Mahshahr, Iran, prompting local assessments of damage.With less than ninety minutes remaining, diplomatic channels intensified. Pakistani officials, including the military chief Asim Munir, facilitated talks that culminated in a two‑week, double‑sided cease‑fire announced by Trump at 22:45 GMT. The United States claimed to have received a “workable” 10‑point proposal from Tehran.Iranian Foreign Minister Abbas Araghchi quickly confirmed the truce, stating Iran would honor it provided attacks on its territory ceased. Sharif then invited both Iranian and US delegations to Islamabad for further negotiations aimed at a permanent settlement.Early Wednesday, Trump’s tone shifted dramatically. In a Truth Social post he hailed the cease‑fire as a potential “Golden Age for the Middle East,” celebrating the pause in hostilities and the reopening of the Strait of Hormuz.The episode underscores how last‑minute diplomacy, spearheaded by Pakistan, averted a catastrophic escalation and opened a narrow window for a broader peace process in a region long mired in conflict.

During Donald Trump’s January 2025 inauguration, Giorgia Meloni was the only European leader invited, underscoring a brief period of close personal and diplomatic ties between Italy’s right‑wing government and the new U.S. administration. A month earlier she had been photographed sharing a private conversation with Trump at the Élysée Palace while President Emmanuel Macron celebrated the reopening of Notre‑Dame. From the outset of Trump’s second term, the Italian premier was hailed by the U.S. president as a “real live wire” and the European ally who could help “straighten out the world.” Meloni embraced the role, describing Trump as a “brilliant man” and promising to "make the West great again" together. That camaraderie has now eroded. In the wake of the US‑Israeli military action against Iran, Meloni told reporters during a Gulf‑region visit that "when we don’t agree, we must say it", explicitly rejecting the war. Her stance was reinforced a week earlier when Italy denied U.S. bombers permission to refuel at a southern base. Political analysts note that Meloni’s shift marks a decisive break from Trump’s agenda. Roberto D’Alimonte, a political‑science professor at Luiss University, warned that her earlier attempt to act as a bridge between Trump and European allies has become a “liability” she now seeks to repair. Public opinion reflects the change. Recent polls show a solid majority of Italians oppose the Iran war, and support for Trump in Italy has plunged from 35 % to just 19 %. The backlash also manifested in a recent referendum on judicial reform, where 61 % of voters aged 18‑34 rejected Meloni’s proposal—a defeat analysts link more to dissatisfaction with her foreign‑policy alignment than to the reform itself. Beyond politics, the conflict threatens Italy’s economy. As the EU’s second‑largest natural‑gas consumer—accounting for roughly 40 % of its energy mix—Italy is feeling the impact of soaring energy prices caused by the near‑total shutdown of traffic through the Strait of Hormuz. The Bank of Italy now projects only a 0.5 % growth rate for 2026‑27, down from earlier forecasts, while the national statistics office reported that Italy’s fiscal deficit has breached the EU’s 3 % ceiling, limiting fiscal flexibility ahead of next year’s elections. Despite these pressures, Meloni has not completely abandoned the United States. In March she declined Trump’s request to dispatch Italian warships to the Strait of Hormuz, aligning with other European nations, yet she stopped short of condemning the US‑led operation outright. Experts argue that Meloni’s approach is deliberately cautious. “She is pragmatic and politically skilled,” D’Alimonte said. “She will continue to balance criticism of Trump’s aggressive foreign policy with the need to preserve strategic ties, moving step‑by‑step toward a stronger European alignment without burning bridges.”

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

The recent ceasefire between the US and Iran offers a glimmer of hope for the energy crisis that has been exacerbated by the conflict in the Strait of Hormuz. However, the deal's stability is already being questioned, with Iran claiming that Israel's attacks on Lebanon breach the agreement. Even if the ceasefire holds and hundreds of tankers stranded in the Gulf start to transit once more, analysts fear that it will not be enough to return the flow of oil, gas, chemicals, and other vital items to pre-crisis levels. An estimated 2,000 vessels with about 20,000 seafarers onboard have been trapped in the Gulf since the outbreak of the conflict. Shipping analysts and owners have cautioned that even a temporary ceasefire does not provide a sufficient guarantee that it is safe to make the passage, particularly because Iran's foreign minister has stated that transit will be under Iranian military management. Many questions remain for shipowners and their captains over whether it is safe to navigate through the strait. The disruption has been compounded by the forced shutdown of oil and gas production across the Gulf as storage facilities reached capacity. In addition, many key energy production sites have been damaged by drone attacks. Experts have said it could take months or years to fully restore the Gulf's energy production. Energy markets have fallen sharply on the hope that millions of barrels of crude oil and gas trapped in the Gulf could soon help to relieve a crisis that the International Energy Agency has said is more serious than the energy flashpoints in 1973, 1979, and 2022 combined. However, traders are also expected to price in a continuing 'geopolitical risk premium' to reflect uncertainty over whether the ceasefire will hold.

The US and Iran have agreed to a two-week ceasefire, leading to a decrease in UK interest rate hike expectations. City traders now predict only one rate rise by December, taking the Bank of England's base rate back to 4%. Previously, markets had priced in two rate hikes as tensions escalated, with Donald Trump warning of severe consequences if Iran did not comply with his demands. However, with the ceasefire in place, rate expectations have fallen, and only 32 basis points of hikes are now expected for the year, down from 62 basis points the previous day. The decline in rate expectations is linked to the significant drop in oil prices, with Brent crude down 13.3% to $94.71 a barrel. This decrease in oil prices could bring relief to UK consumers, potentially leading to lower petrol prices and easing inflationary pressures. Despite the current relief, experts caution that mortgage rates may not fall quickly. The average two-year fixed-rate mortgage has risen to 5.90%, the highest since July 2024. Analysts suggest that while the ceasefire may slow or pause mortgage rate increases, it is unlikely to trigger sharp falls. Chris Beauchamp, chief market analyst at IG, notes that the ceasefire brings relief for UK consumers but emphasizes that the chances of a rate hike by the Bank of England have been reduced. He adds that the 'heady days' of sustained rate cuts are unlikely to return in the short term. Adam French, head of consumer finance at Moneyfacts, advises that while easing tensions have pushed down expectations for future interest rate rises, mortgage rates are likely to remain higher for some time yet, with lenders cautious about making sudden moves due to market volatility.

Opening new oil and gas fields in the North Sea would send a shock wave around the world, senior climate diplomats warned, saying the move would imperil international climate targets, erode the United Kingdom’s reputation as a climate leader and embolden developing countries to exploit their own fossil‑fuel reserves.The UK government faces intense lobbying from the oil industry, Conservative MPs, Nigel Farage’s Reform UK party, certain trade unions and factions within the Treasury. Yet research shows that new drilling would do little to lower energy prices and would have almost no impact on gas imports.Two of the remaining large North Sea prospects – the Rosebank and Jackdaw fields – sit in a basin that is over 90% depleted and increasingly costly to develop. Even if fully exploited, they would displace only about 1% and 2% of the UK’s gas imports respectively, according to recent analysis.Senior figures in international climate diplomacy described the prospect of new drilling as dangerous for global emissions‑reduction efforts and a step back from the phase‑out of fossil fuels.Lord Nicolas Stern, professor at the London School of Economics, warned that “new drilling and a slowdown in climate action would be bad for growth and for energy security in the UK, and a damaging signal for the world.” He added that the UK’s pioneering climate legislation and its role as the first G7 nation to commit to net‑zero by 2050 give its actions “extra weight” on the global stage.An anonymous senior African negotiator reacted angrily to the proposal, stating that Africa would “reject any proposal for the UK to expand oil drilling” because it is “fundamentally inconsistent with both the letter and spirit of the Paris Agreement” and would “weaken trust with climate‑vulnerable nations”.Christiana Figueres, former UN climate chief and co‑founder of the Global Optimism think‑tank, argued that true energy independence lies in “scaling clean, domestic energy, not in extending the life of declining industries”. She cautioned that reverting to old‑fashioned oil expansion would lock in infrastructure at odds with the direction of the global energy system.The UK has been a vocal supporter of an upcoming conference in Colombia on the “transition away from fossil fuels”, a pledge made three years ago at COP28 that remains largely unfulfilled. However, the Guardian learned that Ed Miliband, the UK secretary of state for energy security and net‑zero, will not attend; the government’s climate envoy, Rachel Kyte, will travel in his place.Campaigners had urged Miliband’s presence, citing his pivotal role in securing a last‑minute deal at COP30 in Brazil last November.Experts caution that licensing new fields before the Colombian summit could undermine progress in persuading developing nations to forgo fossil‑fuel‑based economies and adopt cleaner energy pathways.Mohamed Adow, director of the Power Shift Africa think‑tank, warned that a UK approval would “send a shock wave around the world that short‑term interests are being prioritised over long‑term responsibility”. He stressed that many African countries are being asked to leapfrog to clean energy with limited financial support, and that wealthy nations continuing to invest in fossil fuels “undermine this message and diminish their credibility”.Several developing‑country officials echoed this concern, asking, “Why shouldn’t we tap into our own fossil‑fuel resources if the UK is doing so?” They argued that leadership on climate must be consistent with actions.An ally of Miliband praised the UK’s stance, calling “no new exploration licences” a “landmark global leadership position” that shows a major oil‑producing country can align policy with climate science to avoid a 3‑4°C warming scenario.A government spokesperson reaffirmed the administration’s commitment, stating that the UK has placed “clean energy and climate at the heart of its agenda”, and that it will continue to “stop issuing licences to explore new fields, in line with the science and in securing a just transition in the North Sea”.

In the small fishing village of Ghana Town, along The Gambia's Atlantic coast, hundreds of residents are trapped in a legal grey zone, lacking citizenship, passports, and national identification. The town was founded in the late 1950s by 10 Ghanaian fishermen, and over the years, their families have grown, but most descendants remain undocumented.According to Gambian law, a person born to non-Gambian parents is not recognized as a citizen, even if born in the country. About 850 of the town's 900 residents lack citizenship, making it difficult for them to access basic services like education, healthcare, and formal employment.Marie Mensah, a 30-year-old resident, faces significant challenges in obtaining documentation for her children, who attend a fee-paying private school due to the lack of national identity documents. Without official papers, residents are excluded from formal sectors and face difficulties in building a stable future.The situation has led to some residents being forced to send their families abroad in search of a better future. Emmanuel Dadson, a 36-year-old teacher, sent his wife and children to Ghana, where they may be able to obtain citizenship. The lack of documentation has also interrupted dreams and future plans, with some residents, like Joseph Oddoh, being unable to pursue higher education or travel abroad.Human rights experts and community leaders call for reforms to address the issue of statelessness in Gambia, including guaranteed nationality for children who would otherwise be stateless and stronger birth registration processes. The Gambia Commission for Refugees has promised to regularize the residents' status, but progress has been slow due to limited funding.

India's nuclear program has reached a significant milestone with its prototype fast breeder reactor (PFBR) achieving criticality, a self-sustaining nuclear chain reaction. Located in Kalpakkam, Tamil Nadu, the 500 megawatt electrical (MWe) reactor is a major leap forward for India's atomic energy ambitions. The PFBR is only the second commercial fast breeder reactor in the world, following Russia's. This advanced reactor design produces more fissile material than it consumes, using a mix of uranium and plutonium as fuel. The reactor's success is a crucial step towards India's goal of significantly increasing its nuclear energy capacity. Indian Prime Minister Narendra Modi hailed the achievement as 'a proud moment for India' and 'a defining step' in advancing the country's nuclear program. The reactor is designed to enable India to extract greater energy from its limited uranium reserves while paving the way for large-scale deployment of thorium-based reactors. India has more than 25 percent of the world's thorium reserves, which are four times larger than uranium reserves globally. The country's three-stage nuclear program aims to utilize thorium as a primary fuel source in the third stage, with the PFBR serving as a critical component in this process. Experts highlight that the PFBR's success could inspire other countries to adopt similar technology, but challenges remain, including high costs and technical complexities. The reactor's electricity generation is expected to be more expensive than alternatives, including solar energy. Despite these challenges, India's achievement marks a significant advancement in nuclear technology and energy security, particularly for a country with growing energy demands and a desire to reduce dependence on fossil fuels.

The White House has firmly denied that it has any plans to use nuclear weapons against Iran, amid escalating tensions and a looming deadline imposed by President Donald Trump. Trump has warned that if Iran does not capitulate to his demands, a 'whole civilisation will die tonight'.The denial from Washington came as Trump employed apocalyptic language, insisting that Iran must make a deal or face a massive onslaught. The original ultimatum was made by Trump on Saturday, demanding that Iran open the Strait of Hormuz, through which about a fifth of global energy exports pass, or face an assault on key infrastructure.The deadline falls at 8pm Eastern time (00:00 GMT), and legal experts warn that targeting civilian infrastructure could amount to a war crime. Texas Democratic Congressman Joaquin Castro called on Trump to immediately clarify that he is not considering using nuclear weapons.Vice President JD Vance later stated that US forces could employ tools they 'so far haven't decided to use', sparking concerns. The Iranian response has been defiant, with the Islamic Revolutionary Guards Corps (IRGC) vowing to respond in kind if the US attacks civilian facilities.Iran has proposed a 10-point peace plan to end the war, which Trump called a 'significant step' but 'not good enough'. The situation remains volatile, with Israel-US strikes on Iran and Iranian attacks across the region and Israel intensifying.