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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

Lead: A Bold Fusion of Realism and HorrorClaire Fuller returns with Hunger and Thirst, a novel that fuses the gritty texture of social realism with the unsettling atmosphere of gothic horror. Set in 1987, the story follows Ursula, a young woman haunted by the deaths of her mother and a later, more sinister companion, while the narrative oscillates between documentary‑style observation and nightmarish spectacle.Fuller Blends Social Realism with Gothic Horror in 'Hunger and Thirst'The novel opens with Ursula’s traumatic childhood—spending two days trapped in a Moroccan bathroom by her mother’s corpse after a dengue fever death. By sixteen, she drifts through seven children’s homes before landing a postroom job at Winchester School of Art, where she meets the volatile Sue and her boyfriend Vince. Their obsession with horror films like The Shining and The Stepford Wives steers the plot toward a derelict house, the Underwood, where a seance and a reenactment of a past murder blur the line between art and atrocity. Fuller’s prose captures the “porousness” of identity, as characters literally and figuratively inhabit each other’s bodies.Publication Details and PricingPublisher: Fig TreeRelease price: £18.99Publication year: 2026Previous award: Fuller’s 2021 Costa‑winning Unsettled GroundSocial Critique of Thatcher‑Era Care System Through HorrorThe novel uses its horror framework to expose the under‑resourced British care system of the 1980s, a period when Thatcher’s government prioritized nuclear families over community support. Ursula’s movement between children’s homes and a “halfway house” populated by addicts and ex‑prisoners illustrates the systemic neglect that left many youths adrift. By juxtaposing this social critique with visceral horror, Fuller argues that the genre can convey truths about societal failure more starkly than conventional realism.Potential Legacy and Reader ReceptionFuller’s “outrageous aesthetic gamble” may set a new benchmark for literary horror that does not sacrifice social urgency. If readers and critics embrace the novel’s dual narrative—documentary‑style observation paired with gothic terror—it could inspire a wave of fiction that treats horror as a vehicle for political commentary. The book’s blend of “intense feeling” and “intimate portrayal” positions it as a contender for future literary awards and a touchstone for authors exploring the intersection of genre and social critique.

Lead: War Day 84 Marks a Shift Toward DiplomacyThe conflict between Iran and the United States entered its 84th day with renewed diplomatic activity. Both sides are exchanging draft proposals, and US Secretary of State Marco Rubio highlighted "some good signs" while President Donald Trump warned of "very drastic" action if Tehran refuses to relinquish its uranium stockpiles.Mediated Negotiations Gain MomentumPakistani officials are conducting "intense mediation activity" in Tehran, according to Al Jazeera correspondent Almigdad Alruhaid. Senior Iranian sources say negotiators are close to a draft framework, though others caution that a final agreement remains premature.Pakistani mediation is accelerating to prevent further escalation.US‑Iran red‑line shift: Cato Institute senior fellow Doug Bandow stresses the need for both parties to move beyond entrenched nuclear red lines.Key Figures and Financial Stakes7,200 civilians rescued from rubble by the Iranian Red Crescent.More than two dozen MQ‑9 Reaper drones destroyed, losses estimated at $1 bn (≈20% of pre‑war inventory).At least 42 US aircraft damaged or destroyed, total losses near $2.6 bn.US has paused a $14 bn arms sale to Taiwan to preserve munitions for the Iran campaign.Regional and Military ImplicationsCentcom reports the USS Abraham Lincoln strike group remains at "peak readiness" in the Arabian Sea, signaling continued pressure despite diplomatic overtures. Meanwhile, Israeli strikes in southern Lebanon and new US sanctions on Hezbollah allies heighten the risk of a broader regional flare‑up.Outlook for a Potential DealIf the current draft proposals survive scrutiny, a diplomatic settlement could emerge within weeks, easing military pressure and opening pathways for humanitarian aid. However, the dual track of high‑cost equipment losses and political warnings from both Washington and Tehran suggests that any agreement will require substantial concessions on nuclear constraints and future US military commitments in the region.

The Lead: A Bold Re‑imagining of Garland’s Final YearsThe Guardian’s review opens by noting that Drag Race star Jinkx Monsoon brings her celebrated Judy Garland impersonation to a new narrative context—a love triangle set in 1960s London. The revival of Peter Quilter’s 2005 play shifts focus from Garland’s early exploitation to her later struggles with addiction and a fraught personal life.The Production’s Narrative Twist: Love, Addiction, and Queer IconographyMonsoon’s Garland is caught between steadfast pianist Anthony (Adam Filipe) and opportunistic suitor Mickey (Jacob Dudman).The script juxtaposes private hotel scenes with public performances at Talk of the Town, highlighting the clash between fame and personal decay.Queer themes surface through Anthony’s admiration and Mickey’s homophobic contempt, underscoring Garland’s status as a queer icon.Musical Direction and Visual Design: Orchestrating EmotionMusic direction by Nick Barstow and arrangements by Leo Munby anchor the drama, with Garland’s torch songs—"Just in Time" and "You Made Me Love You"—serving as emotional pivots.Designer Jasmine Swan creates a stark white‑curtain stage, while lighting designer Prema Mehta introduces a Technicolor‑inspired transition that mirrors Garland’s cinematic legacy.Critical Reception: Performance Nuances and Structural FlawsMonsoon’s vocal performance is praised for its dynamic range, capturing both triumph and fragility.The review notes repetitive hotel scenes that, while authentic to addiction’s grind, can feel grindingly static.Supporting characters are deemed functional, serving more as narrative devices than fully fleshed personalities.Future Outlook: Potential for a One‑Woman ShowcaseThe critic suggests that Monsoon’s talent hints at a possible solo rendition of Garland’s story, which could amplify the intimate connection she already establishes with the audience. The show runs at Soho Theatre Walthamstow until 21 June, offering theatre‑goers a chance to experience this layered homage before any further developments.

English Heritage has finished a 7‑metre‑high, £1 million reconstruction of a 4,500‑year‑old Neolithic hall, called the Kusuma Neolithic Hall, near the Stonehenge visitor centre. The structure is slated to open to the public this summer and will later serve as an immersive educational hub for schools. Recreating a 4,500‑Year‑Old Neolithic Hall at Stonehenge The hall is based on the archaeological footprint of Durrington 68, a “square‑in‑the‑circle” building discovered two miles from Stonehenge. Excavations first began in 1928 by Maud Cunnington and were revisited in 2007 by the Stonehenge Riverside Project. The reconstruction features a horseshoe‑shaped ring of post holes and four massive internal roof‑support pillars, mirroring the original layout. Experimental archaeologist Luke Winter oversaw the design, using Neolithic carpentry studies and pollen data to ensure authenticity. Every timber was shaped with replica stone tools, and the frame was aligned with the winter solstice – the shadow of the central post falls precisely on the midsummer sunrise. £1 Million Investment and Volunteer Workforce Cost: £1 million Construction period: nine months Volunteer involvement: >100 volunteers contributed hand‑crafted timber work Opening: Summer 2026 Future educational capacity: aim to serve nearly 100,000 students annually by 2031 Educational and Cultural Impact on Heritage Tourism The hall forms the first phase of English Heritage’s broader educational expansion, which will also include the Clore Discovery Lab and Weston Learning Studio, scheduled for completion by the end of 2026. By offering a free, hands‑on experience – from making prehistoric cheese to shaping pottery – the project is expected to boost visitor numbers and deepen public engagement with Neolithic heritage. Curator Win Scutt emphasizes that the reconstruction highlights the communal spirit of Neolithic societies, providing a tangible illustration of how ancient peoples built collective monuments as expressions of social identity. Future Role in Neolithic Research and Learning Beyond tourism, the hall serves as a living laboratory for researchers. The experimental construction process has already shifted expert confidence from a 50 % to a 75 % likelihood that the original Durrington 68 structure was roofed. Ongoing studies will use the hall to test hypotheses about building techniques, seasonal alignments, and social organization. As the site opens to schools, it will become a model for immersive archaeology, potentially inspiring similar reconstructions across the United Kingdom and informing curriculum development for the national education programme on the Neolithic period.

The LeadA friend of mine was recently left in tears after filling up the car she relies on to drive to work. Thanks to the US-Israeli attacks on Iran, prices at the pumps have soared. She wasn't sure how her family was going to make it to the next paycheck.It is a personal story and a distressing one, but the big picture is truly obscene. Fossil fuel companies are raking in monstrous, unearned war profits taken from the pockets of people like you, me, my friend, and any of us who fills up a vehicle or pays an energy bill.The War-Profits Bonanza$30m an hour: that's the pure, unearned profits banked by the world's top 100 oil and gas companies in the first month of the conflict in Iran, purely due to the spike in the oil price. Now the first numbers are in, and that $30m may have been a major underestimate.Shell's profit for the first three months of 2026 more than doubled to $6.9bn, as did BP's, to $3.2bn. TotalEnergies profits also surged by more than 50%, up to $5.8bn. Even in the Gulf itself, where the flow of oil through the strait of Hormuz has been heavily restricted, some companies have still flourished. Aramco, the state oil company of Saudi Arabia, saw its profits soar by 26% to $33.6bn in the first quarter.The Financial Impact on ConsumersThose four companies alone, benefiting not just from the oil price hike but also bumper oil-trading profits, made $23m an hour for the whole of January, February and March. And the Iran conflict only started on 28 February.To get some idea of the scale of this, imagine I gave you $6,200. What would you do? Pay off a loan? Book a fancy holiday? A second later, I give you another $6,200; then again, for hours, weeks and months. That is the rate of profit of just those four companies.There is plenty more to come for the industry. Oil and gas supplies will take months to return to prewar levels, and reserves are getting dangerously low. Even if the oil price remains at today's level of about $100 a barrel, those 100 companies will make $234bn by the end of the year. Remember, the companies, and petrostates such as Russia, have done no extra work for this, just ridden a soaring oil price. Also remember, you are paying for this. Where I live in the UK, household energy bills are about to jump by £209 ($280) a year for the average home.The Industry's Climate ObstructionThe profits are extreme, but not new: big oil and gas has been wildly profitable for decades. It has made an average $1tn a year in pure profit for about 50 years. The fossil fuel sector also benefits from explicit subsidies that totalled $1.3tn in 2022, according to the International Monetary Fund.These riches have funded the lobbying and campaigns that block climate action and have done so for years, long after the science became crystal clear. As an example of the consequences, the UK's official climate advisers said on Tuesday that all care homes and hospitals will need air conditioning within the coming 10 years, to stop the heat killing people.The Green Transition AccelerationBut here's that silver lining I promised: these peak profits contain the seeds of their own downfall. Sky-high fossil fuel prices are pushing people, companies and nations to supercharge their rush towards green power for the simple reason that it is now cheaper and more reliable. Solar power does not need to transit through the strait of Hormuz, as Bill McKibben has observed.The numbers on the surge in renewable energy deployment, already exponential, are not yet in, but they will almost certainly be huge. Green funds are already attracting billions of dollars in new investments and one consultancy estimates that an oil price of $100 a barrel will drive $4tn of extra green investment by 2030.Big oil remains a formidable political force but, on the ground, people are already voting with their feet. Sales of new electric cars in the UK leapt by 59% in April, for example. The pain and anger of today's energy crisis may yet become a critical turning point in confronting the climate crisis.

Police Expand Probe into Prince Andrew's Alleged MisconductThames Valley Police (TVP) announced that their “unprecedented investigation” into Prince Andrew, 66 now covers a wide range of possible offences – from sexual misconduct to fraud and the illegal sharing of confidential information. The force is urging witnesses to contact them via the official online portal with any relevant details. Scope, Timeline and Key Evidence GapsFebruary 2026 – Prince Andrew arrested and questioned under criminal caution on suspicion of misconduct in public office (MIPO) linked to his role as a British trade envoy.Investigators are seeking original US Department of Justice documents that reference alleged information sharing with Jeffrey Epstein. Only printed extracts have been obtained so far.TVP is reviewing a claim from a US‑based woman who says she was taken to Windsor in 2010 for sexual purposes; the police have contacted her lawyer but have not opened a full criminal investigation.Three other UK forces are conducting separate criminal inquiries stemming from the same Epstein files, while the Metropolitan Police declined to open its own probe. Potential Political and Institutional RepercussionsThe investigation touches several sensitive arenas: the credibility of the royal household, the legal definition of MIPO for a trade envoy, and the UK’s cooperation with US authorities on high‑profile financial crimes. If evidence confirms that the prince used his diplomatic position to pass confidential information, it could trigger a constitutional debate over the limits of royal privilege and the Crown’s role in public office. What the Next Months May Hold for the InquiryPolice expect the probe to extend well into 2027, contingent on obtaining the original Epstein documents and completing forensic analysis of seized material from the prince’s Norfolk and Windsor residences. Formal discussions with the Crown Prosecution Service are already underway, suggesting that charges could be considered once the evidentiary threshold is met. Meanwhile, the appeal for public tips aims to fill information gaps that could accelerate the timeline.

Executive Summary of the Podcast EpisodeThe Guardian’s latest podcast follows hunters who argue that shooting big game can help preserve Africa’s wildlife, sparking a nuanced discussion on conservation strategies.Episode Focus and How to Access ItListen or read: Read the text version hereSupport the Guardian: theguardian.com/longreadpodRelated Publication Highlighted in the EpisodeThe episode references Adapted from The Savage Landscape: How We Made the Wilderness by Cal Flyn, published by William Collins on 7 May. The book can be ordered via guardianbookshop.com.Visual Context ProvidedPhotograph: ReutersWhy This Conversation MattersThe podcast adds to ongoing debates about the role of regulated hunting in wildlife management, offering perspectives from those directly involved in the practice.Looking AheadFuture episodes and related reporting are expected to continue exploring the complex balance between hunting, conservation funding, and ecosystem health across Africa.

Hull KR's Crushing Warm‑up Sets a Bold Tone for WembleyHull KR delivered a relentless performance against an under‑strength Wigan Warriors, leading 42‑0 at the break and finishing with 11 tries. The win narrows the gap to the league leaders, St Helens, to just two points.Wigan’s Experimental Line‑up and the Rationale Behind ItCoach Matt Peet rested the majority of the 17‑man squad slated for the Challenge Cup final, fielding eight debutants and only three players over 23. The approach was described as “intelligent” workload management, but the heavy defeat has drawn scrutiny.Scoreline and Statistical BreakdownHalf‑time lead: 42‑0Total tries: Hull KR 11, Wigan 1Key performers: Mikey Lewis hat‑trick, tries by Tom Davies, Jez Litten, Jai Whitbread, Rhyse MartinWigan’s lone try by Nathan LoweImplications for the Super League Playoff Race and TV RightsThe victory propels Hull KR within two points of the leaders, intensifying the battle for playoff positions. With the Super League TV contract up for renewal, a one‑sided warm‑up raises concerns about the marketability of a final that may appear predictable.Outlook for the Challenge Cup Final at WembleyBoth clubs will reassess their strategies before the final in nine days. While Wigan hopes the rest will restore its senior talent, Hull KR will look to maintain momentum. The final will likely be a true test of depth versus experience.