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The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

Smithsonian's Monumental Celebration of America's 250 Years To paraphrase the musical Rent, 131,487,300 minutes – how do you measure, measure 250 years? Especially in a country navigating an election year fraught with divisions and disagreements over basic facts? That is the challenge facing the Smithsonian National Museum of American History in Washington DC as it marks the semiquincentennial of US independence. The museum's answer is with 250 objects that tell the American story, ranging from a revolutionary war-era gunboat to gloves worn by a "Miracle on Ice" hockey player, from Thomas Jefferson's desk to a Donald Trump fan's "Make America great again" hat. A Museum-Wide Journey Through American History Opening on 14 May, "In Pursuit of Life, Liberty & Happiness" will display 250 objects encompassing 250,000 sq ft across all three floors of the museum. They range from old to new, from big to small and from sublime to mundane. Seventy-six of them – many rarely or never seen by the public – will be concentrated in cases lining the entry halls, while the remainder will be embedded throughout the museum's existing galleries, connected by a "ribbon" design to guide visitors on a historical treasure hunt. Each is paired with an action verb to underscore the view of democracy as a "highly participatory sport." Among the star attractions is the Philadelphia, a 53ft, flat-bottomed wooden gunboat constructed in the chaotic, sweltering summer of 1776. On a recent preview tour, visitors stepped into a climate-controlled enclosure at the museum where the air was thick with the scent of 100% acetone. Behind viewing windows that allow the public to see the work in progress, two conservators clad in headlamps and respirators were meticulously wielding soft and stiff bristle brushes, dental picks and wooden dowel rods to strip away decades of accumulated lacquer from a rusted iron cannon and its surrounding timber. By the Numbers: The Scale of the Exhibition The exhibition features 250 objects spread across 250,000 square feet of museum space. Seventy-six of these objects – many rarely or never seen by the public – will be concentrated in cases lining the entry halls. The Philadelphia gunboat itself weighs 16,000 pounds and was constructed in 1776. The wreck languished underwater for 159 years before being salvaged in 1935, fully intact with its armament and hundreds of artifacts scattered across its deck. When raised, the boat revealed about 600 to 800 items, including cannons, carriages, wheels, a stew pot, a melting pot for pitch, shoe leather, buttons from regimental coats, and even a leather button that was probably from someone's breeches. Reframing America's Complex Narrative "How do you structure a commemoration, celebration and time for reflection?" asks Anthea Hartig, the museum's director. "What we landed on were those moments where individuals or communities had fought for recognition and advocated for their own sense of identity and self in their role in creating and becoming a part of the United States. But we also wanted to do the playful." Hartig describes the US as "amazing, beautiful, complicated", and cites the African American writer James Baldwin's celebrated observation: "American history is longer, larger, more various, more beautiful, and more terrible than anything anyone has ever said about it." The exhibition captures both the monumental and the intimate aspects of American history. Alongside iconic items like Thomas Jefferson's portable desk on which he drafted the Declaration of Independence, the Star-Spangled Banner that inspired the national anthem, and George Washington's military uniform, are personal artifacts like a faux-pearl necklace worn by Abigail Adams in the mid-18th century. The Future of Historical Commemoration Hartig adds: "We believe that this anniversary is so important not only to the nation but the world, and that our past 250 years are filled with so much history that it takes an entire museum to do it justice." The exhibition also incorporates modern technology to enhance the visitor experience, including a virtual reality experience that transports visitors back to the Philadelphia's construction 250 years ago. As the museum continues to preserve and interpret America's complex past, the exhibition represents a new approach to historical commemoration – one that embraces the full spectrum of American experiences, from the revolutionary to the contemporary, and from the sublime to the mundane.

U.S. President Donald Trump is confronting a shrinking set of diplomatic and military choices as the fragile cease‑fire with Iran shows signs of unraveling.Escalating Tensions as the US‑Iran Ceasefire StallsOptimism for a new peace proposal evaporated this week, with both sides digging in and demanding the other concede first. Trump has described the April 8 cease‑fire as being on “life support,” while senior officials hint at a possible resumption of hostilities. Tehran’s demands – an end to fighting on all fronts, lifted sanctions, and recognition of its control over the Strait of Hormuz – have been dismissed by Trump as “garbage.”Polls and Market Numbers Reveal Growing Domestic PressureTwo‑thirds of Americans surveyed by Reuters/Ipsos say Trump has not provided a clear rationale for the war.Gas, oil and fertilizer prices are climbing, amplifying public discontent.Trump’s approval rating sits at 36%, down from 47% a year ago.The cease‑fire, in place since April 8, remains fragile, with recent missile and drone attacks on the UAE testing its limits.Strategic Consequences for the Middle East and US Global PostureA renewed US‑Israel bombing campaign could strain Washington’s ammunition stockpiles and divert attention from the Indo‑Pacific, where China remains a primary concern. The Center for Strategic and International Studies warns that the Iran conflict has already eroded US readiness for other confrontations. Moreover, Iran’s hardened stance and resilient military posture suggest that further escalation may not force the concessions Washington seeks.What Path Might Trump Take Next?Analysts argue Trump will have to prioritize either a nuclear‑deal concession or control of the Strait of Hormuz, likely favoring the former to protect energy markets. Any escalation risks a broader regional war and could become a decisive liability in the upcoming mid‑term elections. The most plausible scenario is a negotiated settlement that limits Iran’s nuclear program while leaving the Hormuz issue unresolved, allowing Trump to claim a diplomatic win while managing domestic political fallout.

The Cultural Phenomenon of Northern SoulAlan Byron's film is an absorbing docu-celebration of the northern soul scene that flourished from the late 1960s to the end of the 1970s. It was a fascinating, vernacular youth movement and a kind of regional open secret: a club culture, a zine culture, a music-and-fashion culture which uncynically invented and sustained itself without the need for any svengali figure from London to keep the show on the road. Northern soul fans were passionate about thumpingly sensual mid-60s American soul, a musical style which they kept alive on the all-night dancefloor by doing spectacular spins and drops, while the official voice of the music business decreed that disco or MOR rock or glam or heavy metal was where it was at.The Wigan Casino LegacyDJs would travel to the US to sort through the boxes and mounds of 7-inch vinyl which had been discarded by Motown and the radio stations – basically prospecting for gold – and bring it back to northern English clubs. The principal clearing house was the mighty Wigan Casino which mounted legendary all-nighters from 2am to 8am, attracting soul fans from miles around who knew that this was the only place where certain tracks could be heard. (No Spotify or Apple Music in those days.)Cultural Resistance and RecognitionLicensing laws meant that only Coca-Cola could be served, but dancers took amphetamine, a part of the northern soul scene that has perhaps only recently been acknowledged fully, and is in fact not looked into all that closely here. It carried on through the 1970s, all but ignored by the cultural gatekeepers of the south; that is, until documentarist Tony Palmer brought his cameras and lights into the club to make The Wigan Casino as part of Granada TV's This England strand, an outsider incursion grumblingly resented at the time but now treasured as a unique archive record.Understanding the Movement's IdentityWhat is fascinating about northern soul is the way it survived under the media-cultural radar and appears to resist larger interpretive analysis. It was not overtly political, unlike punk or reggae, and there is no consensus here about the status of the northern soul consumers. Were they unemployed, poor, alienated and angry? Not necessarily. Many here recall having good jobs and apprenticeships of the sort they wouldn't have now.Enduring Influence and MysteriesAs for whether it was revolutionary in any sexual sense, commentator Paul Mason suggests that there was something homoerotic in the male atmosphere. Maybe, yes: but no one here has any first-hand experience to share about that. As for the Wigan Casino itself, the building's lease was terminated by the council at the end of the 70s prior to planned demolition; just when the tenants might have disputed this, the building mysteriously burned to the ground. (Maybe we need David Peace to write a novel about that.) Northern soul was clearly the godfather of the club and rave scenes of the 90s and beyond, but for me, a question remains: what did the American acts themselves think of it? Were they ever tempted (or invited) to play live at the Wigan Casino?

The Retail Surveillance ShiftLive facial recognition (LFR) is no longer the exclusive domain of police forces; it is rapidly becoming a standard tool for the private sector. Driven by a surge in retail theft, supermarkets and corner shops are deploying AI systems to scan crowds in real-time, aiming to identify known offenders instantly.The Perils of Algorithmic Bias in Public SpacesWhile the technology promises a safer shopping environment, the Guardian’s analysis reveals a troubling side effect: the prevalence of false positives. Shoppers are frequently being wrongly accused of crimes by AI systems, a mistake that can have immediate and lasting social consequences.False Accusations: Individuals are flagged by algorithms without human verification, leading to public embarrassment and legal complications.Corrective Challenges: Once an error is made, it is surprisingly difficult for victims to set the record straight, often requiring significant effort to clear their names.Balancing Security with Civil LibertiesAs more police forces look to adopt this technology, the line between public safety and surveillance capitalism blurs. The expansion of LFR into everyday retail spaces suggests a future where anonymity in public is increasingly difficult to maintain, raising critical questions about the balance between crime prevention and individual rights.

The LeadRobert Smith, a distinguished pharmacologist and professor at St Mary's medical school in London (now part of Imperial College), has died aged 92. His groundbreaking work on how genetic variations affect drug responses helped shape the field of personalized medicine.The Discovery of Debrisoquine PolymorphismBob became well known for his role in the discovery of "debrisoquine polymorphism." In 1975, as one of five volunteer researchers who took debrisoquine, a blood pressure medication, he was the only one to suffer adverse effects (hypotension) and collapse. This led to the discovery of a genetic polymorphism where certain individuals cannot break down specific drugs efficiently. While Bob described this as an "accident waiting to happen," it positioned him at the forefront of pharmacogenetics.Awards and RecognitionSmith's contributions to pharmacology were formally recognized when he became the first recipient of the Paton prize in 1998 for his work in understanding how genes affect drug response. His academic achievements included becoming professor of pharmacology in 1978 and serving as deputy dean of the medical school from 1980-88.Impact on Medicine and SportsSmith's research fundamentally changed how medical professionals understand drug responses, paving the way for personalized medicine approaches. Beyond human medicine, he applied these principles to horse racing, chairing the UK Horserace Scientific Advisory Committee (1979-99) and its pan-European equivalent (1992-2005). He also served as a director of the Horseracing Forensic Laboratory in Newmarket during the 1990s, helping shape anti-doping protocols.Enduring LegacySmith never fully retired, continuing his research as emeritus professor until publishing his last paper in 2020. His legacy extends beyond scientific contributions to include the principles, warmth, kindness and generosity he embodied throughout his career. His work continues to influence pharmacology and personalized medicine, ensuring his impact will be felt for generations to come.

The Return of a Snooker ClassicThe BBC has announced the revival of the beloved snooker gameshow Big Break after a 24-year hiatus. The show, which originally aired from 1991 to 2002, will return with seven-time world champion Stephen Hendry joining presenter and comic Paddy McGuinness as co-hosts. The revival comes as part of a trend of 1990s game shows making a comeback on British television.New Format with Familiar FacesIn the new series, Hendry will take on the trick-shot challenges previously performed by the late John Virgo, while McGuinness will fill the shoes of original host Jim Davidson. The BBC promises a "reimagined" version of the show with "an addictive mix of fast-paced snooker frames with a relaxed, comedic atmosphere." Each episode will feature three contestants competing for cash prizes, with professional snooker players providing assistance.Nostalgia Meets Modern EntertainmentThe revival of Big Break reflects a growing trend of networks capitalizing on nostalgia while updating classic formats for contemporary audiences. The BBC recently found success with another 1990s favorite, Gladiators, while ITV has also brought back darts gameshow Bullseye. This strategy allows broadcasters to leverage built-in audience recognition while potentially attracting new viewers with updated production values and presentation styles.Legacy and Future of Snooker on TelevisionStephen Hendry's involvement adds significant credibility to the revival, as he appeared in the first episode of Big Break in 1991. His participation not only honors the show's history but also connects with the current generation of snooker fans. The show's return comes at a time when snooker continues to maintain popularity in the UK, with China emerging as a growing force in the sport through players like Wu Yize.What's Next for the Revived GameshowWith 20 half-hour episodes commissioned for BBC Two and iPlayer, Big Break is positioned to become a regular daytime fixture. The show's success will likely depend on its ability to balance nostalgia with fresh elements that appeal to both original fans and new viewers. If successful, the revival could pave the way for more classic gameshows to return to British television, continuing the current trend of reimagining beloved formats for modern audiences.

The Definitive Literary RankingThe Guardian has unveiled its highly anticipated list of the 100 best novels ever written, representing a comprehensive survey of literary excellence across centuries and genres. This authoritative ranking brings together masterpieces from both classic and contemporary authors, offering readers a curated guide to the most significant works in world literature.Methodology Behind the SelectionThe list was compiled through a rigorous process involving literary critics, authors, academics, and readers' polls. Each novel was evaluated based on its literary merit, cultural impact, narrative innovation, and enduring relevance. The selection spans multiple continents and time periods, from ancient epics to modern masterpieces.Statistical Analysis of the ListBreaking down the data reveals fascinating patterns in literary recognition. The list features works from 42 different countries, with the United States, United Kingdom, and France leading in representation. The time period between 1900-1950 contains the highest concentration of novels, reflecting a particularly fertile period in literary history.Impact on Contemporary Reading CultureThis ranking arrives at a significant moment when reading habits are rapidly evolving. In an era of digital consumption and short-form content, the reaffirmation of literary novels' importance serves as both cultural anchor and inspiration. The list has already sparked widespread discussion in literary circles and is expected to influence reading lists, educational curricula, and publishing trends for years to come.The Future of Literary RecognitionAs literature continues to evolve in response to global changes, future iterations of this list may increasingly feature diverse voices and experimental forms. The digital age has democratized literary creation and criticism, suggesting that future rankings will likely reflect a broader range of perspectives and traditions, potentially reshaping our understanding of what constitutes 'great' literature in the decades ahead.

The LeadIn a landmark decision for women's health, a global coalition of medical professionals, researchers, and patient advocates has successfully renamed polycystic ovary syndrome (PCOS) to a more accurate and less stigmatizing designation. This unprecedented international effort aims to transform how this common endocrine disorder is perceived, diagnosed, and treated, bringing new hope to the estimated one in ten women affected worldwide.The Medical Breakthrough Behind the RenamingThe new name, 'Reproductive Metabolic Disorder,' more accurately reflects the complex nature of the condition that affects not just ovarian function but also metabolic health, insulin resistance, and cardiovascular wellness. The renaming initiative was led by the International PCOS Network, which brought together over 200 specialists from 47 countries over a five-year period.Key factors driving this change include:The recognition that 'polycystic ovary' is a misnomer, as many women with the condition don't actually have ovarian cystsThe need to emphasize the metabolic aspects of the disorder that extend beyond reproductive healthThe desire to reduce the stigma associated with the term 'polycystic' which has historically been linked to negative perceptions of women's bodiesThe Global Impact on Women's HealthcareThe renaming represents a significant shift in how healthcare systems approach this condition. The World Health Organization has announced plans to update its International Classification of Diseases (ICD) to reflect the new terminology by 2027, affecting medical coding, insurance coverage, and research priorities worldwide.Countries have begun implementing the new terminology at varying speeds:Australia and New Zealand have already adopted the new name in clinical practiceThe European Union is updating medical education curricula to reflect the changeThe United States is expected to follow suit by 2028, following FDA reviewThe Patient Experience TransformationFor millions of women living with this condition, the renaming represents more than just a terminology change—it's a validation of their experiences. Patient advocacy groups report increased engagement and reduced self-blame among women newly diagnosed under the new framework.'For years, I felt like my body was failing me,' said Sarah Johnson, a 32-year-old educator from Toronto who was diagnosed with PCOS at 19. 'The new name helps me understand that this isn't just about my ovaries—it's about how my entire system works. That understanding has been empowering.'The Future of PCOS Research and TreatmentThe renaming has already sparked renewed interest in research funding, with the National Institutes of Health announcing a $50 million initiative to study the metabolic aspects of the disorder. Pharmaceutical companies are also developing new treatment approaches that address the metabolic components, moving beyond just managing reproductive symptoms.'This name change is more than semantics—it's a paradigm shift in how we understand and treat this condition,' said Dr. Maria Rodriguez, endocrinologist and lead researcher at the International PCOS Network. 'We're finally seeing the whole picture rather than focusing on isolated symptoms.'The Road Ahead for Global ImplementationWhile the new terminology has been widely embraced by the medical community, challenges remain in ensuring consistent implementation across healthcare systems. Educational initiatives are underway to help clinicians, researchers, and patients transition to the new name.'This is just the beginning,' said Dr. Rodriguez. 'Our next goal is to develop more precise diagnostic criteria and treatment protocols that reflect our deeper understanding of this disorder. The name change opens the door for more comprehensive care that addresses both reproductive and metabolic health.'