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A British warship together with a Royal Air Force P‑8 maritime patrol aircraft monitored three Russian submarines that were trying to survey key undersea infrastructure in the North Atlantic, the defence secretary John Healey said at a Downing Street briefing.Healey explained that the operation, which lasted **over a month**, took place not within UK territorial waters but in the country's exclusive economic zone – the area extending up to 200 nautical miles from the coastline and bordering neighbouring zones.The Russian vessels comprised an Akula‑class nuclear‑powered submarine and two deep‑sea research submarines from the GUGI directorate, a unit that normally conducts peacetime surveys of underwater infrastructure but possesses the capability to damage it in conflict.According to the minister, the British forces tracked and deterred any malign activity around the submarines 24/7, deploying regular sonar buoys to demonstrate continuous monitoring. The presence of the Royal Navy ship and the P‑8 aircraft, supported by NATO allies, left the Russian crews with “no doubt that they were being watched”.As a result, the Akula submarine “retreated home” and the two GUGI subs subsequently exited the UK’s maritime zone, heading northward. The operation involved **about 500 UK personnel**.Healey stressed that there was **no evidence of damage** to any pipelines or cables, but that UK forces and allies would verify the integrity of the infrastructure. He warned President Putin that any attempt to sabotage the network would “not be tolerated and will have serious consequences”.The defence secretary framed the incident as proof that Moscow is “the primary threat to the UK and to NATO”, underscoring the need for heightened vigilance over undersea assets amid the broader security fallout from the Ukraine war and recent tensions in the Middle East.He also linked the episode to broader defence policy, stating that the successful deterrence demonstrates the UK’s ability to detect, deter and, if necessary, respond to threats against its critical maritime infrastructure, while calling for continued investment in defence capabilities.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Jon McClure, the Sheffield‑born frontman of Reverend and the Makers, has taken a seat on the board of Sheffield FC – the world’s oldest football club – after joining a new minority‑ownership group with David Bianchi. The move marks the first time the musician has taken on a formal role in a football institution.McClure, a lifelong Wednesday supporter, first approached the club eight years ago but felt he wasn’t yet “in a mature enough position” to steward a cultural landmark. Since last month he has been actively reviewing the club’s operations and seeking ways to modernise a team that currently competes in the ninth tier of English football.The appointment comes as Sheffield FC enjoys a surge in interest, having recorded a club‑record league attendance of 1,172 spectators for a recent defeat to Tadcaster. The side will host the same opponents again in a Northern Counties East League playoff semi‑final after finishing third in the division.Unlike the high‑profile takeovers at Dagenham & Redbridge or Wrexham, McClure insists his approach will be “more considered”. He acknowledges the club’s history of “years of dysfunction” and warns against “putting rocket boosters on a three‑wheeler”, emphasizing a need for steady stabilisation before growth.Founded in 1857, Sheffield FC’s claim to fame is its role in codifying the modern game – a narrative McClure says is “still under‑told”. The club boasts the first football kit, the first recorded derby and a unique FIFA order of merit shared only with Real Madrid, offering “global IP opportunities”, according to the chair.To translate heritage into footfall, McClure has introduced free entry for children, hoping to lift typical matchday crowds from 300‑400 to larger numbers. He also highlights a logistical hurdle: the club’s “Home of Football” ground sits in Dronfield, Derbyshire, outside Sheffield’s city limits, prompting a long‑term ambition to relocate to a multi‑purpose venue in the city centre.McClure’s celebrity connections are already bearing fruit. He invited Sheffield music legend Richard Hawley to a recent fixture and maintains a friendly rapport with Sheffield United manager Chris Wilder, despite the historic rivalry between the city’s clubs.In a nod to modern digital culture, McClure’s brother Chris created the viral persona “Steve Bracknall”, the fictional assistant manager of the Royal Oak. When the Royal Oak played a real match at Sheffield FC, the event drew over 2,000 fans on the ground and half a million online viewers, including Robbie Williams, branding it “the biggest game in Sunday league history”.Looking ahead, McClure is keen to expand the club’s junior and women’s programmes, envisioning an “1857 Academy” that could scale globally if built on the right foundations. While a leap to the Northern Premier League is the realistic target, the broader goal is to cement Sheffield FC as a thriving community hub that honors its status as the birthplace of football.

The Norwegian Nobel Committee, which awards the Nobel Peace Prize, has publicly condemned Moscow’s latest effort to label the human‑rights organisation Memorial as an "extremist organisation". Chairman Jørgen Watne Frydnes said the committee is "deeply alarmed" by the Russian authorities’ attempt to dismantle a co‑recipient of the 2022 Peace Prize. According to the statement released on Wednesday, Russia’s Supreme Court is set to review a petition from the Ministry of Justice that seeks to add Memorial to the nation’s list of “undesirable” entities. If approved, the designation would ban the group from operating within Russia and expose anyone associated with it to up to four years in prison and substantial fines. Memorial, already branded a “foreign agent” and ordered dissolved by the Supreme Court at the end of 2021, would see all of its activities criminalised under the new petition, Frydnes warned. He added that even sharing the organisation’s published material could lead to imprisonment. “To designate such an organisation as extremist is an affront to the fundamental values of human dignity and freedom of expression,” Frydnes asserted, urging Russian officials to withdraw the claim immediately and cease all harassment of Memorial and its members. Memorial shared the 2022 Nobel Peace Prize with Ukraine’s Centre for Civil Liberties and Belarusian activist Ales Bialiatski. Founded in 1987, Memorial specialises in documenting human‑rights violations across Russia and once operated a network of roughly 50 affiliated groups both inside and outside the country. Several of these affiliates continue their work from bases in Germany, France and Italy. Key figures from Memorial have faced criminal proceedings in Russia. Notably, activist Oleg Orlov, who was sentenced for speaking out against the war in Ukraine, was released in a 2024 prisoner exchange and now works abroad to continue documenting abuses. The committee’s statement concludes with a direct appeal: Russian authorities should immediately rescind the extremist label and halt any further intimidation of the organisation and its supporters.

Ecuador has escalated tensions with Colombia by recalling its ambassador, Arturo Felix Wong, from Bogota. This move comes in response to criticisms from Colombian President Gustavo Petro regarding the case of former Ecuadorian Vice President Jorge Glas, who is currently serving a lengthy prison sentence for corruption.Glas, a left-wing figure, has been at the center of a high-profile criminal case that has stirred tensions across Latin America. He was arrested in a controversial police raid on the Mexican embassy in Quito two years ago, where he had sought asylum. The raid was authorized by the right-wing government of Ecuadorian President Daniel Noboa, who has denounced criticisms of the Glas case as a violation of his country's sovereignty.President Petro has referred to Glas as a 'political prisoner' and has called for his transfer to Colombian custody after granting him citizenship last September. Petro has also raised concerns about Glas's health and wellbeing, stating that he is suffering from severe malnutrition and muscle mass loss due to his imprisonment.The diplomatic row between Ecuador and Colombia is part of a long-running spat between the two leaders. Since March, Noboa has imposed 50-percent tariffs on Colombian imports, accusing Colombia of being too lax in its fight against drug trafficking. Petro, in turn, has accused Noboa of carrying out a bombing campaign near the Colombian border, resulting in the recovery of 27 charred bodies.Ecuador's Foreign Minister, Gabriela Sommerfeld, confirmed the recall of the ambassador, stating that the criticisms of the Glas case were 'uncalled for and a provocation'. The move is seen as a further escalation of tensions between the two countries, which have been experiencing strained relations since the Mexican embassy raid in 2024.

In a shocking escalation of violence, civilians in Gaza's Maghazi camp were caught in the crossfire as rival armed groups clashed, leaving 10 people dead and 44 injured. The incident occurred on Monday, with eyewitnesses describing scenes of panic and chaos as armed men stormed homes and a school run by the United Nations Relief and Works Agency for Palestine Refugees (UNRWA).The violence began when armed groups approached from the direction of the "yellow line" that separates Palestinian and Israeli-controlled areas of Gaza. The groups, allegedly backed by Israeli forces, moved towards civilian homes and the Al-Maghazi Preparatory Boys School, which is sheltering large numbers of displaced people.Residents reported that the armed men, who identified themselves as the "Popular Forces combating terrorism", a rival group to Hamas, broke into homes, detained family members, and used the houses as cover during the battle. The family of Asaad Nteel, who was caught up in the violence, described being ordered to gather in one room and not move, fearing harm to themselves and their children.The clashes, which lasted for over an hour and a half, caused extreme distress to residents, who do not support these groups. Local people claim the armed men were provided with cover and support by Israeli forces, with some eyewitnesses reporting the use of armed drones to aid the armed men's withdrawal.The Palestinian Centre for Human Rights has documented previous violence by these groups, including looting of aid convoys, kidnappings, torture, and killings, with cover or support from the Israeli army. The centre has called for an urgent independent investigation, accountability for those responsible, and effective protection for civilians.The incident has sparked widespread outrage on social media, with activists sharing videos documenting victims being transported to hospitals. The violence has also raised concerns about the emerging armed groups in Gaza, which appear to operate near areas along the "yellow line".Since the ceasefire between Israel and Hamas supposedly began on October 11, 733 Palestinians have been killed in Gaza, and 2,034 injured, in addition to 759 bodies recovered. The situation remains dire, with civilians continuing to bear the brunt of the conflict.

As the clock ticked down to President Donald Trump’s 8 p.m. deadline to force the reopening of the Strait of Hormuz, the six‑week Middle East conflict teetered on the brink of a far more devastating escalation.Trump’s rhetoric had escalated dramatically, with his Truth Social posts warning that the United States would unleash strikes capable of “decimating every bridge and power plant in Iran” and that “a whole civilisation will die tonight.” Legal experts labeled the language as bordering on a genocidal threat.Amid the rising tension, a series of rapid developments unfolded on Tuesday:12:06 GMT – Trump announced a plan to target Iran’s civilian infrastructure, promising total destruction of bridges and power facilities.15:21 GMT – Iranian media confirmed that US strikes hit Kharg Island, the nation’s primary oil‑export hub, but reported no significant damage.15:40 GMT – In the UN Security Council, China and Russia vetoed a Bahraini resolution aimed at protecting commercial shipping in the Strait of Hormuz, arguing the draft was biased against Tehran.16:54 GMT – Qatar’s defence ministry reported a successful missile interception, while the United Arab Emirates warned of a barrage of missile and drone attacks.18:23 GMT – Iran’s envoy to Pakistan, Reza Amiri Moghadam, signalled a “step forward” after a “critical, sensitive stage,” praising Pakistan’s “positive and productive” peace efforts.19:17 GMT – Pakistani Prime Minister Shehbaz Sharif appealed to Trump to extend the deadline by two weeks, urging Tehran to keep the Strait open as a goodwill gesture.20:25 GMT – Iran warned it would target US and Gulf‑allied energy infrastructure, threatening to block regional oil and gas supplies for years.20:41 GMT – Joint US‑Israeli airstrikes struck the Amirkabir Petrochemical Plant in Mahshahr, Iran, prompting local assessments of damage.With less than ninety minutes remaining, diplomatic channels intensified. Pakistani officials, including the military chief Asim Munir, facilitated talks that culminated in a two‑week, double‑sided cease‑fire announced by Trump at 22:45 GMT. The United States claimed to have received a “workable” 10‑point proposal from Tehran.Iranian Foreign Minister Abbas Araghchi quickly confirmed the truce, stating Iran would honor it provided attacks on its territory ceased. Sharif then invited both Iranian and US delegations to Islamabad for further negotiations aimed at a permanent settlement.Early Wednesday, Trump’s tone shifted dramatically. In a Truth Social post he hailed the cease‑fire as a potential “Golden Age for the Middle East,” celebrating the pause in hostilities and the reopening of the Strait of Hormuz.The episode underscores how last‑minute diplomacy, spearheaded by Pakistan, averted a catastrophic escalation and opened a narrow window for a broader peace process in a region long mired in conflict.

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The temporary cease‑fire in the US‑Israel‑Iran war has given Iran and China a strategic opening to challenge the US dollar’s supremacy in global finance. Both nations share a common objective: to reduce reliance on the greenback, especially in the oil sector where, according to a 2023 JP Morgan estimate, roughly 80% of transactions are settled in dollars. In a practical step toward this goal, Iran’s de‑facto toll‑booth system in the Strait of Hormuz—a chokepoint that handles about one‑fifth of the world’s oil and LNG shipments—has started accepting transit fees in Chinese yuan. Lloyd’s List reported that at least two vessels had already paid in yuan by March 25, and China’s Ministry of Commerce later acknowledged the reports on social media. Iran’s embassy in Zimbabwe even called for the introduction of a “petroyuan” to the global oil market, underscoring the political symbolism of the move. While Tehran pledged to guarantee safe passage for two weeks under a US‑brokered cease‑fire, Beijing declined to comment. Harvard economist Kenneth Rogoff told Al Jazeera that Iran’s actions serve a dual purpose: they “poke a thumb in the United States’s eye” and provide a practical alternative to dollar‑based sanctions. Rogoff added that Iran’s shift to yuan aligns with China’s broader effort to redenominate trade among BRICS nations. For both countries, the yuan offers a way to sidestep US sanctions and lower transaction costs. Their trade relationship, cemented by a 25‑year strategic partnership signed in 2021, sees China buying over 80% of Iran’s oil—often at discounted rates—while Iran imports Chinese machinery, electronics, chemicals, and industrial components. Data from Kpler and TankerTrackers indicate that, despite the conflict, Iran’s oil exports to China have remained near pre‑war levels, ranging between 12 million and 13.7 million barrels in the first two weeks of hostilities. China’s ambition to elevate the yuan is long‑standing. President Xi Jinping, in a 2024 address, expressed hope that the yuan would become a global reserve currency. Yet significant hurdles remain: the yuan is not freely convertible due to strict capital controls, and the Chinese financial system is perceived as opaque, limiting broader adoption. According to the IMF, the dollar still dominated global foreign‑exchange reserves at 57% last year, far ahead of the euro’s 20% and the yuan’s modest 2%. Cross‑border trade settled in yuan rose to 3.7% in 2024, up from under 1% in 2012, per S&P; Global—an encouraging but limited shift. Natixis chief economist Alicia Garcia‑Herrero cautioned that the Strait of Hormuz experiment adds only “incremental pressure” and that a true “de‑dollarisation” would require Gulf states, which have priced oil in dollars since the 1970s in exchange for US security guarantees. European analyst Hosuk Lee‑Makiyama highlighted that China’s ability to supply Iran with essential goods makes the yuan a viable alternative, a dynamic not possible for Europe or Japan. He described China as the closest the world has seen to a “manufacturing one‑stop shop.” Consultancy founder Dan Steinbock echoed that while the dollar’s supremacy is unlikely to crumble overnight, the gradual increase in yuan usage could “chip away” at US dominance in specific sectors over time. Rogoff concluded that the long‑term impact hinges on the war’s outcome. If Iran and China emerge stronger, many countries may diversify away from the dollar to avoid US‑imposed financial constraints. Conversely, a decisive US victory could reinforce dollar hegemony for the foreseeable future.