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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

In what can only be described as a humiliating exit, Liverpool were beaten 4‑0 by Manchester City in the FA Cup quarter‑final, a result that has thrown the future of manager Arne Slot into further doubt.The Etihad crowd watched City dominate from the first whistle, with Erling Haaland completing a hat‑trick by the 57th minute. The Norwegian’s third came from open play after a series of defensive lapses, sealing a comprehensive victory that left Liverpool supporters emptying the upper tiers of the South Stand.Liverpool’s own chances were squandered. Mohamed Salah missed a late penalty, a rare misfire that underscored his waning influence. Earlier, Virgil van Dijk conceded his fourth penalty of the season – a stark contrast to the single penalty he had given up in his previous 319 Premier League appearances for the club.Mid‑fielder Dominik Szoboszlai offered a blunt self‑assessment after the match, stating, “The fighting spirit wasn’t there enough, the mentality wasn’t there enough. None of us were there to be honest as much as we could.” His words captured the collective lack of resolve that defined Liverpool’s performance.Beyond the immediate disappointment, the defeat raises the stakes for Slot’s upcoming Champions League quarter‑final first leg against Paris Saint‑Germain. With Liverpool still carrying the Premier League’s highest wage bill, the club’s hierarchy and fans will be watching closely to see whether the team can salvage the season or face a deeper crisis.The match exposed systemic issues: a static defense that allowed City’s left‑back Antoine Semenyo and striker Erling Haaland to exploit gaps, a goalkeeper positioning that appeared indecisive, and a general absence of leadership on the pitch. As the season progresses, the spotlight remains firmly on Slot, whose tenure now hinges on a single chance to revive Liverpool’s dwindling fortunes.

Leeds United travel to West Ham for an FA Cup quarter‑final that both clubs would prefer to avoid, yet manager Daniel Farke is clear about his priorities. With an MA in economics and a diploma in sporting directorship, he stresses that Premier League survival is the club’s "bread and butter" and must come first.Off the pitch, the German‑born coach unwinds by immersing himself in literary fiction, counting Gabriel García Márquez’s One Hundred Years of Solitude among his favourites.Farke’s dual role as a tactician and a storyteller raises the question of whether he can engineer a season that delivers both survival and cup glory. A successful double could make it hard for the Elland Road hierarchy to deny him the new contract he desires."I’m a big believer in cup competitions," Farke said, emphasizing that Leeds will approach the West Ham tie "very, very seriously". He added that the squad will start strong unless a player shows a physical issue, in which case they will be protected.The risk of fielding a first‑choice XI against a relegation rival mirrors the 2013 Wigan experience, when the club won the FA Cup but suffered relegation three days later – a bittersweet double that highlighted the fine line between triumph and disaster.Leeds have failed to win any of their last six Premier League matches, drawing four, a run that has stalled momentum. A victory could act as a catalyst to change the narrative as the season draws to a close.Injury concerns loom over striker Dominic Calvert‑Lewin, who is undergoing a hamstring scan. The England international, who netted seven goals in six games at the end of 2025, has managed only two league goals this season. A fit Calvert‑Lewin could revive Leeds’ hopes of reaching their first FA Cup semi‑final since 1987 and keep his World Cup aspirations alive.The goalkeeping position also remains unsettled. After losing his starting spot to Karl Darlow, Lucas Perri has featured solely in the FA Cup this year, leaving the decision on who starts for the West Ham tie open.Financial pressures add urgency to Farke’s decisions. Leeds’ latest accounts reveal a £49.2 million pre‑tax loss for the year ending June 2025, and a costly stadium expansion project that would be jeopardised by relegation. This backdrop explains the psychological blow of a 1‑0 loss to an under‑strength Sunderland side earlier in the month.Farke believes a deep FA Cup run could erase lingering self‑doubt. "If we secure Premier League survival and go further in the FA Cup, we can write a special chapter for this club," he said, urging his squad to seize the chance to make history.

Defense Secretary Pete Hegseth instructed Army Chief of Staff General Randy A. George to step down with immediate effect, a move announced on X by Pentagon spokesperson Sean Parnell on Thursday. The statement said George would "retire from his position" but offered no explanation, a notable omission given the ongoing US‑Israel war against Iran.The abrupt removal adds to a string of high‑profile dismissals that have occurred since Hegseth assumed office in January. CBS first reported the decision, citing a source who said Hegseth seeks a leader who will execute his and President Donald Trump's strategic vision for the Army.Appointed in 2023 under former President Joe Biden, the 61‑year‑old General George brought extensive combat experience from Iraq and Afghanistan. During his tenure he was praised for cutting redundancies and championing new technologies such as low‑cost missile‑interceptor drones and artificial‑intelligence‑driven targeting systems.According to The New York Times, the firing may be tied to a dispute over Hegseth’s decision to block the promotion of four officers from a list of 29. While most of the blocked officers were white men, the two remaining were Black and two were women, prompting senior officers to question whether racial or gender bias influenced the action. When General George sought a meeting with Hegseth to discuss the matter, the defense secretary reportedly refused.In addition to George, Hegseth dismissed two other senior officials on Thursday: General David M. Hodne, head of the Army’s Transformation and Training Command responsible for modernization efforts, and Major General William Green Jr., the Army’s chief of chaplains. The Pentagon has not formally confirmed these removals, though the Joint Chiefs of Staff issued a tribute praising George’s decades of service.The personnel shake‑up unfolds against a broader backdrop in which US and Israeli officials have framed the Iran war as a religious undertaking. The Military Religious Freedom Foundation reported receiving complaints that senior commanders described the conflict as aiming to bring about “Armageddon” or the biblical “end times.”Earlier, in October, former Army Vice Chief of Staff General James J. Mingus retired a year ahead of schedule, with no reasons disclosed, adding to speculation about internal turbulence within the Pentagon.

President Donald Trump announced on Truth Social that Pam Bondi is being removed as Attorney General, ending a contentious 14‑month stint at the Justice Department. Bondi, who described her upcoming shift to the private sector as a "transition," will leave the post within the next month. In a rapid reshuffle, Trump elevated Deputy Attorney General Todd Blanche—who previously served as the former president’s criminal‑defense lawyer—to acting attorney general. The president also hinted that EPA Administrator Lee Zeldin could become the permanent replacement, signaling a continued preference for close allies in key legal roles. Bondi’s ouster follows a series of high‑profile controversies. Most notably, her management of the Jeffrey Epstein files drew intense scrutiny. After promising full transparency, the Justice Department released heavily redacted documents that failed to satisfy public and congressional demands for a "client list" and other evidence. Critics, including victims’ attorney Gloria Allred, called her departure "long overdue" for mishandling the files. Beyond the Epstein saga, Bondi struggled to deliver the political prosecutions Trump expected. Efforts to pursue former FBI Director James Comey and other officials linked to investigations of the president stalled or collapsed, fueling Trump’s frustration that she was not "weaponising" the department aggressively enough against his perceived enemies. Bondi, a former Florida attorney general and the state’s first female AG, built a reputation on tough‑on‑crime initiatives such as combating human trafficking and cracking down on "pill mills." However, her limited involvement in the original Epstein non‑prosecution deal and her heated exchange with a Democratic lawmaker—where she called him a "washed‑up loser"—further eroded confidence in her leadership. The White House confirmed that Bondi’s private‑sector role will be announced "in the near future," while Blanche issued a statement on X thanking Trump for the trust placed in him and pledging to "continue backing the blue, enforcing the law, and keeping America safe." Congressional oversight intensifies as the House Oversight Committee had scheduled Bondi to appear before it on April 14 to answer questions about the Epstein documents. With her exit, committee chair James Comer said Republicans would deliberate whether to pursue the subpoena, while Democrats, led by Robert Garcia, insist she "will not escape accountability." Reactions span the political spectrum: Democrats such as Senator Elizabeth Warren denounced the DOJ under Bondi as a "cesspool of corruption," whereas Republican Senator Chuck Grassley praised her responsiveness to oversight and noted a decline in violent crime during her tenure. Republican Thomas Massie urged the next AG to release all Epstein files and pursue arrests. As the administration searches for a permanent attorney general, the choice between Blanche and Zeldin will signal how closely Trump intends to align the Justice Department with his political agenda moving forward.

US senators have strongly rebuked Ticketmaster for increasing ticket fees following a regulatory crackdown on hidden charges. This move has been described as a 'bait and switch' tactic, leaving consumers with higher costs.The Federal Trade Commission (FTC) had mandated Ticketmaster to disclose all concert ticket fees upfront, known as all-in pricing, starting last May. In response, the company removed the order processing fee charged at the end of a transaction. However, documents obtained by the Guardian reveal that Ticketmaster simply raised other fees to offset the loss, potentially violating the FTC's ban on misleading fees.Senator Richard Blumenthal from Connecticut expressed his concerns, stating, 'Ticketmaster seems to believe it has a get-out-of-jail-free card to ignore antitrust and consumer protection laws. The FTC is going to have to choose whether to protect consumers and enforce the law, or cave to Ticketmaster lobbyists.'The FTC had sued Ticketmaster and its parent company, Live Nation Entertainment, last September for hiding mandatory fees until the end of the transaction. Ticketmaster claims it complies with the FTC's all-in pricing rules.In response to the criticism, Ticketmaster stated, 'Since May 2025, tickets on Ticketmaster.com have displayed the full price upfront in line with the FTC's all-in pricing rule. We also provide explanations of fees during the purchase process and maintain a dedicated page with additional information.'Senator Elizabeth Warren from Massachusetts also criticized Ticketmaster, saying, 'Too many giant monopolies think the law doesn’t apply to them, and it’s American families who are forced to pay the price.'An ongoing federal trial is examining whether Ticketmaster operates an illegal monopoly in the live music industry. The company denies these allegations.

Donald Trump has sparked a new low in UK-US relations by mocking Prime Minister Keir Starmer, claiming the UK leader is weak and indecisive. During an Easter lunch speech at the White House, Trump impersonated Starmer, saying the prime minister told him he needed to consult his team before deciding whether to send UK aircraft carriers to the Middle East.Trump stated, 'I asked [the] UK, who should be our best. In fact the king is coming over here in two weeks, he’s a nice guy, King Charles. But should be our best but they weren’t our best. I said: ‘You have two, old broken-down aircraft carriers, do you think you could send them over?’' He then mimicked Starmer, saying, '“Ohhh, I’ll have to ask my team.”' Trump added, '“I said: ‘You’re the prime minister, you don’t have to.’”The US president also mocked Emmanuel Macron, saying the French president was “still recovering from the right to the jaw” and claimed that Macron’s wife, Brigitte, “treats him extremely badly”. These remarks were made at a lunch that was not open to the press but were released by the White House on a social media channel and later deleted.However, Whitehall sources disputed Trump’s claims, stating that he had never asked the UK for the vessels and Britain had not offered them. Despite the controversy, Starmer has remained firm in his stance on the war, saying he would stick to his position “whatever the pressure and the noise”. When asked about Trump’s comments, Starmer emphasized his focus on the British national interest and his determination not to be swayed by external pressure.

Pakistan reaffirmed its commitment to steer the United States and Iran back to the negotiating table, even as it faces "obstacles" that were not disclosed by Foreign Office spokesperson Tahir Andrabi during a weekly briefing in Islamabad.The statement came hours after U.S. President Donald Trump warned he would bomb Iran "back to the Stone Ages" if Tehran rejected Washington’s peace terms, underscoring the volatile backdrop to Pakistan’s diplomatic push.Andrabi emphasized that Pakistan will continue to "promote facilitation and dialogue" and is working to create conditions for meaningful negotiations among relevant stakeholders. He noted that both Washington and Tehran view Pakistan as a neutral intermediary.In a tangible sign of confidence, Iran has permitted 20 Pakistani‑flagged vessels to transit the Strait of Hormuz. Andrabi described this as "a harbinger of peace" and a positive step for regional stability, though he did not confirm whether any ships have already sailed.The Hormuz corridor has been largely blocked since Iran curtailed oil and gas shipments after the outbreak of the US‑Israel‑Iran conflict on February 28, driving up energy prices and straining economies across the region.High‑level contact between Islamabad and Tehran continues. Andrabi cited a March 28 call between Iranian President Masoud Pezeshkian and Pakistani Prime Minister Shehbaz Sharif, during which both leaders stressed the need to "build trust" and praised Pakistan’s "supportive role for peace".Regional diplomacy intensified after Deputy Prime Minister and Foreign Minister Ishaq Dar returned from Beijing, where he met Chinese Foreign Minister Wang Yi. The two sides produced a joint five‑point initiative calling for an immediate ceasefire, urgent diplomatic engagement, and the restoration of normal maritime traffic through the Strait of Hormuz.Andrabi said the China‑Pakistan proposal has been shared with the United States, Iran and other stakeholders, receiving appreciation "across the region and beyond". The plan aligns with outcomes from a four‑nation ministerial meeting in Islamabad that included Saudi Arabia, Turkey and Egypt.Despite a hairline fracture sustained during the Islamabad talks, Dar travelled to Beijing, underscoring Pakistan’s strategic partnership with China. He later announced that Pakistan is ready to host direct US‑Iran negotiations in the coming days, a proposal reiterated by Andrabi at the briefing.While Pakistan positions itself as a facilitator, Andrabi acknowledged that Iran has so far limited mediation to indirect messages and has not committed to direct talks, stating, "Iran, as a sovereign country, determines its own policies."In a separate diplomatic track, Pakistan sent senior officials to Urumqi, China, for discussions with Afghanistan – the first substantive contact since Islamabad launched cross‑border strikes in late February. Andrabi stressed that Afghanistan must demonstrate "visible and verifiable actions" against terrorist groups operating from its territory.Pakistan continues its Operation Ghazab lil‑Haq, launched on February 26 to target terrorist sanctuaries in Afghanistan after alleged cross‑border fire from Taliban forces. Following a five‑day Eid‑ul‑Fitr pause, the operation remains ongoing.Islamabad accuses the Taliban‑run Kabul government of allowing the Tehrik‑i‑Taliban Pakistan (TTP) to use Afghan soil for attacks inside Pakistan, a claim the Afghan side denies. China has also facilitated Pakistan‑Afghanistan engagement, hosting meetings in Beijing and Kabul earlier in the year.

The US government shutdown affecting the Department of Homeland Security (DHS) will persist, despite the Senate passing a funding bill. The partial shutdown, which began on February 14, will continue until at least Monday, when the House of Representatives reconvenes.The stalemate centers on whether DHS should reform its immigration procedures, following criticism of President Donald Trump’s mass deportation push. Democrats have refused to pass funding to Immigration and Customs Enforcement (ICE) and Customs and Border Protection (CBP) without reforms to their practices.The shutdown has had several knock-on effects, including airport delays and unpaid workers. DHS, which oversees the Transportation Security Administration (TSA), has seen its airport security agents go without pay for six weeks. With agents calling out sick or leaving their jobs, US airports have reported long lines and widespread travel delays.President Trump has endorsed a plan to fully fund DHS, which involves a two-track approach: passing a bill to fund the department, except for ICE and CBP, and then funding ICE and CBP through separate spending legislation. Trump has also vowed to pay 'all' DHS employees, although details on how this will be achieved are unclear.The shutdown has been politically unpopular, with unions and transportation safety groups criticizing the strain it has placed on workers and airport security. Democrats have sought to leverage the funding bill to press for changes to Trump’s immigration policy, while Republicans have accused them of putting Americans' livelihoods in jeopardy for political gains.