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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

Malina Lee, a 31‑year‑old wedding baker from San Antonio, joined TikTok in 2020 to pass the lockdown‑induced boredom and promote her business. Four years later, an anonymous commenter called “PickleFart” noticed an asymmetrical neck in one of her videos and suggested she check for a goiter.The tip proved accurate: doctors confirmed thyroid cancer. Lee received prompt treatment and, within a year, was declared cancer‑free. She told the outlet that her oncologist was amazed at how early the disease was caught, crediting the TikTok comment as the catalyst.Lee’s experience is part of a growing trend where TikTok’s hyper‑targeted algorithm surfaces health‑related content that resonates with users’ unnoticed symptoms. In several cases, community members have flagged potential conditions that clinicians initially missed.The “PickleFart” persona belongs to Billie Jean Tuomi, who calls herself the “thyroid avenger.” A thyroid‑cancer survivor herself (diagnosed in 2012), Tuomi now scans videos for neck asymmetry and gently advises creators to seek a thyroid panel—a blood test measuring hormone levels and antibodies. The American Thyroid Association recommends adults start routine thyroid testing at age 35, or annually for high‑risk individuals.Tuomi estimates she has flagged dozens of videos, with at least four confirmed serious thyroid issues, including Lee’s. She stresses she does not claim to diagnose, merely urges viewers to consult a physician. After a viral comment, she received a flood of private messages with neck photos, prompting her to change her username.Lee, inspired by Tuomi’s intervention, has begun commenting on other users’ videos, helping one individual discover an enlarged thyroid that required removal. She describes the process as a “domino effect” of community‑driven health awareness.Medical professionals acknowledge the double‑edged nature of this phenomenon. Craig Mittleman, director of emergency services at Lawrence + Memorial Hospital, notes a rise in patients arriving with self‑diagnoses sourced from social media. While this can empower patients to ask informed questions, it also burdens clinicians with debunking misinformation.Gender disparities amplify the issue: research shows women are more likely to seek health information online, often after feeling dismissed by traditional providers. TikTok user Tori Mosser, a 23‑year‑old filmmaker, credits a direct message suggesting chronic appendicitis for prompting surgery that resolved her chronic vomiting episodes.Both Lee and Mosser emphasize the therapeutic value of finding a supportive community on TikTok, especially for invisible or chronic illnesses that are frequently minimized in clinical settings.

Rehab did not happen to Lena Dunham; she walked into it. The writer describes the moment she entered a stone‑manor facility in the Berkshires, Massachusetts, and was immediately asked to remove her designer shoes and answer mundane questions about her diet, a surreal welcome that felt like a college orientation—except many of the fellow residents struggled with IV heroin. She notes the unsettling blend of patients and staff, all dressed in ordinary clothes, making it impossible to tell who was who. A tattooed man in a Harley‑Davidson shirt turned out to be a sober companion, while a grandmother knitting in slippers battled a severe Benadryl addiction that had once ruined her daughter’s wedding. “Never judge a drug addict by their Patagonia half‑zip fleece,” she writes. Using the pseudonym “Rose O’Neill” – after the pioneering cartoonist – Dunham reflects on feeling trapped in a cycle reminiscent of the late‑career decline of the early 20th‑century artist. It was only after she allowed staff to use her real name that she began to reclaim her identity. Her therapist, Dr. Mark, a kindly man in khakis, asked her to articulate the root causes of her admission. Dunham linked her descent to chronic physical illness, relentless stress from supporting multiple families, hormonal turmoil after a hysterectomy, and a fraught romantic relationship. She also disclosed past sexual trauma, describing the rehab experience as “a fever dream” that echoed those memories. Medication played a paradoxical role. While Klonopin eased anxiety and Percocet dulled pain, the initial IV dose produced a euphoric “shiver through the whole body, better than any orgasm.” She acknowledges the temporary relief as a “pause button” that allowed her racing thoughts to quiet, yet also recognized the danger of dependence. Group sessions revealed complex dynamics. A fellow patient, Walter, breached confidentiality, prompting staff to enforce policy and send him home. The ensuing discussion divided the group, with some defending Walter’s lapse and others demanding accountability. Dunham’s own voice was subdued, emphasizing the tension between personal safety and collective responsibility. In a values‑mapping exercise, Dunham listed ART, FAMILY, MAKING PEOPLE FEEL SEEN as her core priorities, contrasting them with the values of the people she had surrounded herself with during active addiction. This exercise highlighted the stark misalignment between her aspirations and the environment she had inhabited. Despite the strict regimen, Dunham was granted a brief leave to attend the 2018 Met Gala. The decision sparked intense debate among staff about safety, yet she ultimately walked the red carpet, feeling “wan and haunted” amid flashing cameras and champagne she could not enjoy. The experience underscored the surreal juxtaposition of celebrity life and rehab recovery. During the final week, she formally identified as an addict and faced the pivotal question from Dr. Mark: “Do you want to be sober?” The answer marked a turning point, culminating in a moment of pure joy as she ran outdoors, feeling her legs move of their own accord. She closes with a vivid scene of spotting a robin’s egg on the grass, a simple yet profound reminder of life’s unexpected beauty. The memoir Famesick, published by Fourth Estate on 14 April, expands on these revelations and invites readers into the often‑hidden world of addiction behind the celebrity façade.

The conflict in Gaza has resulted in a significant number of amputations, with over 6,000 adults and children undergoing amputations since October 2023, according to the WHO and Palestinian Ministry of Health. Ola Jamal, 36, is one of the many Palestinians who have been forced to flee Gaza due to the conflict. She was breastfeeding her two-month-old son, Zain, when a missile struck al-Nasr hospital in Gaza, causing her to lose her arm. Jamal and her family were forced to separate, with her children being cared for by another family. This traumatic experience has had a lasting impact on Jamal and her children, with her son Zain still experiencing nightmares and trauma two years after the event. Shadi Sharif Ayesh al-Sous, a father of two, lost his leg in a missile strike while collecting firewood. He had his leg amputated above the knee and now waits to return home to Gaza. However, many Palestinians in Egypt face significant challenges, including restricted access to healthcare and prosthetic care due to their uncertain legal status. Yousef El Deeb, a certified prosthetist at Orthomedics in Cairo, says his clinic has treated about 300 Palestinian patients since October 2023, mostly through the support of NGOs. However, the lack of documentation and uncertain legal status of Palestinians in Egypt makes it difficult for them to access long-term prosthetic care without the support of NGOs. The situation for Palestinians in Egypt is further complicated by their lack of formal residency or refugee status. Without valid residency permits, survivors are often restricted to hostels or share a flat with other families, unable to work and living under the constant pressure of temporary status. This lack of documentation makes accessing hi-tech, long-term prosthetic care almost impossible without the support of NGOs.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Israel's recent bombing of a densely populated residential area near Lebanon's largest public hospital, Rafik Hariri University hospital, has resulted in at least five deaths and 50 injuries. This attack is consistent with Israel's strategy in Lebanon, where human rights organizations and medical workers report that the IDF is targeting hospitals and medics, sometimes in ambulances or first aid centers.Israel's actions in Lebanon mirror its tactics in Gaza, where hospitals and medical equipment were destroyed, and medical workers faced extraordinary challenges, including forced evacuations and threats. The Israeli military claims that Hezbollah exploits medical facilities for 'terrorist activity,' but has not provided evidence to support these claims.The consequences of these attacks are dire. According to the World Health Organization, over 90 'attacks on healthcare' have been reported in Lebanon since March 2, resulting in 137 injuries and 53 deaths. These attacks have led to a crisis of trust in healthcare systems, with patients fearing that hospitals are no longer safe.The precedent set in Gaza and now Lebanon is a dangerous one for future conflicts. When even ambulances are targeted, the rules of engagement are being distorted. The international community must hold Israel accountable for these actions, which are crimes under international law.

Mariam Sabbah, a 10-year-old Palestinian girl, lost her arm in an Israeli missile attack on Gaza and has arrived in the UK for specialist treatment. She was accompanied by her mother, Fatma Salman, and two brothers at Heathrow airport.The family was met with a warm welcome, including gifts, balloons, and bouquets. Mariam's arm was amputated after a missile tore through her family's home in Deir al-Balah. Her family had initially hoped to go to the US for treatment but was unable to due to visa restrictions.According to the World Health Organization (WHO), over 11,000 patients have been evacuated from Gaza, with an estimated 18,500 more in need of urgent care. The UK government had announced a medical evacuation scheme last year, which led to the arrival of Mariam and her family in the UK for privately funded specialized treatment.Aid organizations have called on the UK government to increase efforts to help evacuate critically ill and injured children from Gaza. The WHO announced on Monday that it would suspend medical evacuations after a contracted worker was killed.Mosab Nasser, co-founder of FAJR Global, stated that more lives would be lost due to the WHO's decision. The UK government scheme relies on the WHO to provide a list of patients identified as priority cases by medical specialists in Gaza.Campaigners have expressed concerns that without urgent action, more preventable illness and deaths will occur. Since October 2023, Egypt, the United Arab Emirates, and Qatar have assisted the most number of patients medically evacuated from Gaza.

The World Health Organization (WHO) has suspended medical evacuations from Gaza to Egypt after a contract worker was killed by Israeli fire. The incident occurred on Monday, and WHO Director General Tedros Adhanom Ghebreyesus expressed his devastation over the confirmation of the worker's death.The WHO did not elaborate on the incident but stated that it was under investigation by the relevant authorities. Two staff members who were present during the incident were not injured. The medical evacuation of patients from Gaza via Rafah to Egypt, which had been planned for Monday, was suspended, and further evacuations will remain suspended until further notice.The Rafah crossing, which is the only crossing in Gaza that does not link to Israel, was reopened in February after a long closure by the Israeli military. This crossing is crucial for the entry of humanitarian supplies and for those in need of medical aid to leave and seek treatment abroad. The WHO has been overseeing coordination between Egypt and Israel since the opening of the Rafah crossing to facilitate those evacuations.However, crossing numbers have been far below expectations due to intense checks during the process by the Israeli authorities. Israel has also continued to limit the entry of humanitarian aid into the besieged territory and shut the crossing in the early days of the United States-Israeli war on Iran. Israel has repeatedly violated the ceasefire that came into force on October 10 after two years of devastating war.Referring to the incident on Monday in which a driver of a WHO car was killed, Israel's mission in Geneva said troops identified an unmarked vehicle approaching them and posing an immediate threat and they fired warning shots in response. The vehicle continued to accelerate towards the troops, who then responded with additional fire, and a hit was identified. The incident is under review.