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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Sudden Loss of a Racing Legend Longtime teammates, former rivals and others around the sports world have joined the wave of condolences over the sudden death of Nascar driver Kyle Busch on Thursday. Busch, a two-time Cup Series champion who was the winningest driver across the sport's three series in history, died at 41 after being hospitalized earlier Thursday with a severe illness. No cause of death has been announced. Tributes from the Racing Community "Absolutely cannot comprehend this news," Denny Hamlin, a 22-year Nascar veteran and Busch's former teammate, said on social media. "We just need to think of his family during this time. We love you KB." "There aren't really words for today. I've raced against Kyle for a long time, and anyone who's lined up next to him knows exactly what made him special, he gave you everything he had, every single lap, and he made all of us better for it," driver Ricky Stenhouse Jr said in a post. "But more than the wins and the records, I keep thinking about Samantha, Brexton, and Lennix, and the entire Busch family right now. That's where my heart is. Rest easy, Rowdy. The sport won't be the same without you." A Legendary Career Busch was in his fourth season at Richard Childress Racing. He ranked 24th in the Cup Series standings, with two top-10 finishes in 12 races this season, and had been the Cup Series champion in 2015 and 2019 with Joe Gibbs Racing. He won a Nascar Truck Series race at Dover International Speedway last week and was slated to compete in this weekend's Coca-Cola 600 in Charlotte, North Carolina, before his family announced on Thursday he had been hospitalized. The Impact on the Racing World Dale Earnhardt Jr, an on-track rival after he took over Busch's car after he departed Hendrick Motorsports in 2007 who later became a friend, called Busch one of the "greatest drivers in Nascar history". "Kyle and I had a really challenging existence for many years. But we luckily took the time to figure out our differences and that was something he instigated with a conversation in his bus around how we each managed our racing teams. I was super eager for us to get on better terms. But it was he who made the effort for that to be possible," Earnhardt said. "I will never be able to make sense of this loss but I am thankful that we had found a way to become friends."

The Disco Legend Returns to the SpotlightLost in Music, He's the Greatest Dancer, Thinking of You and We Are Family – many artists would long for just one of these songs at any time in their career, but for Sister Sledge they all appeared on a single side of one of their albums. As she brings these and the rest of the disco group's still-sensational catalogue to the Electric Paradise festival this summer, Kathy Sledge will be joining us to answer your questions.The Rise of Sister SledgeKathy is one of four Sledge sisters along with Debbie, Joni and Kim, who formed the group as children in the mid-1960s, picking up gigs at churches and local events in their home city of Philadelphia as the Sledge Sisters. After flipping the name around, they got a record deal and their first chart success came in the UK in 1973, with the Top 20 hit Mama Never Told Me.The Chic Collaboration That Defined an EraFurther commercial success eluded them for a few years – though that's no reflection on the quality of early disco material such as Pain Reliever – until their label paired them with Chic's Nile Rodgers and Bernard Edwards. Sister Sledge's poise and charisma shone from the aforementioned hits the pair wrote for them, collected on the album We Are Family. The title track reached No 2 in the US and it, along with the others, endure as pinnacles of the disco era.Chart Success Through the DecadesRemixed versions of those songs came back around in 1984 and 1993, each to great success particularly in the UK, though the group's only UK No 1 single was in a very different style in 1985, with the swaying neo-60s pop of Frankie.A Solo Career and Continued PerformancesKathy took the lead vocal on some of their biggest hits, and after Sister Sledge went on hiatus in 1987, she had a solo career interspersed with occasional Sister Sledge reunions, and later – amid some legal wrangles with her sisters – solo tours of Sister Sledge material. Next up she'll perform at Electric Paradise in Milton Keynes, on 8 August, alongside other legends of the era such as Grace Jones, Candi Staton, Kool and the Gang and more.Your Questions for the Disco IconNow 67, Kathy has been in countless nightclubs and recording studios around the world across her multi-decade career, so there's plenty to ask her. Post your questions in the comments below before 6pm GMT on Wednesday, and we'll publish her answers later in the week.

The LeadSouth Korean activists have taken dramatic action against Starbucks' "Tank Day" promotional campaign, publicly smashing coffee cups in protest. The demonstration underscores the complex relationship between global brands and local cultural sensitivities in South Korea.The Tank Day Campaign DetailsThe "Tank Day" campaign appears to be a promotional initiative by Starbucks that references military tanks, a sensitive subject in South Korea due to its divided history with North Korea. Activists argue that the campaign trivializes serious historical and political issues. The protest involved activists publicly destroying Starbucks cups, drawing attention to their opposition through viral social media content.The Impact AnalysisThis protest highlights the challenges global corporations face when entering markets with unique historical sensitivities. South Korea has a complex relationship with military imagery due to its ongoing tensions with North Korea. The incident may prompt Starbucks to reconsider its marketing strategies in the region and could encourage other multinational companies to conduct more thorough cultural assessments before launching campaigns.The PredictionGoing forward, we can expect increased scrutiny of global marketing campaigns in South Korea. Companies may invest more in local cultural consultants to avoid similar controversies. This incident could also lead to stronger movements advocating for culturally appropriate advertising, potentially influencing marketing practices across the region.

The Latest Escalation in Lebanon Israeli attacks have killed at least 11 people in southern Lebanon, including several healthcare workers. The attacks occurred on Friday in the Tyre district and are the latest in a long line, questioning the durability of the shaky United States-mediated ceasefire between Israel and Lebanon. Details of the Attacks At least 11 people killed in Israeli attacks in southern Lebanon Several healthcare workers among the dead, including paramedics and a child Attacks occurred in the Tyre district, including in the municipality of Deir Qanoun en-Nahr and the town of Hannaouiyah The Humanitarian Impact More than 400 people have been killed by Israeli fire since the ceasefire came into force in mid-April. Israel insists it will continue to target the Hezbollah armed group, which opposed the Lebanese government’s agreement on the ceasefire. At least 2,896 people killed in Lebanon since Israeli attacks began More than 8,824 injured and over 1.6 million displaced – about one-fifth of the country’s population The Systematic Destruction of Health Facilities The Israeli military has repeatedly attacked health facilities and medical teams in Lebanon, accusing Hezbollah of using them to conceal weapons and fighters. The Lebanese government rejects that claim. 116 healthcare workers killed since the latest escalation in early March 16 hospitals damaged and 147 ambulances attacked The Future Outlook A ceasefire brokered by the United States came into effect in mid-April, but the violence has continued, and Hezbollah has continued to trade attacks with Israel. The US has imposed sanctions on individuals with links to Hezbollah, including Iran’s ambassador to Lebanon.

The Star Wars Big Screen ConundrumWhen Disney acquired Lucasfilm for $4 billion in 2012, it seemed like a guaranteed success. The initial trilogy of films under Disney's leadership—The Force Awakens, Rogue One, and The Last Jedi—all earned over $1 billion worldwide. However, despite this commercial success, the franchise has faced increasing criticism and fan dissatisfaction. The latest film, The Mandalorian and Grogu, currently holds a 61% rating on Rotten Tomatoes, barely scraping into the "fresh" category. This raises questions about whether Star Wars has become an impossible franchise to successfully translate to the big screen in the modern era.The Disney+ Success FormulaDisney+ has proven to be a successful platform for Star Wars content, with shows like The Mandalorian, Andor, The Book of Boba Fett, Obi-Wan Kenobi, and Ahsoka finding dedicated audiences. These series have allowed Disney to explore corners of the Star Wars universe that films couldn't address, filling plot holes and expanding the mythology. The Mandalorian, in particular, introduced Grogu (Baby Yoda), a character specifically designed for maximum appeal. However, this streaming success has created a challenge: when the same characters and format are brought to the big screen, they may feel more like extended episodes rather than cinematic events.Financial Performance vs. Critical ReceptionDespite the critical challenges, Star Wars films have remained financially successful. The Force Awakens earned over $2 billion worldwide, Rogue One surpassed $1 billion, and even The Rise of Skywalker, which was widely disliked by fans, still earned Disney more than $1 billion. This financial success has allowed Disney to continue producing Star Wars content, but the declining critical reception suggests a growing disconnect between audience expectations and what the franchise delivers. The Mandalorian and Grogu, while profitable, appears to be following this pattern of commercial success mixed with middling critical reviews.The Franchise Identity CrisisThe article suggests that Star Wars is suffering from an identity crisis on the big screen. Disney has tried multiple approaches: soft-rebooting the original trilogy with The Force Awakens, challenging the mythology with The Last Jedi, and attempting to please all fans with The Rise of Skywalker. Each approach has faced backlash from different segments of the fanbase. The Mandalorian and Grogu takes a safer route, focusing on beloved characters without major revelations about the Force or character lineages. This approach may satisfy existing fans but fails to deliver the grand cinematic experience that audiences expect from a Star Wars film on the big screen.The Mythic Structure ProblemA key insight from the article is that the original Star Wars trilogy worked because it had a clear beginning, middle, and end. The story felt complete with the Empire's fall and Luke's redemption. However, subsequent continuations have undone these victories, reopening narrative wounds and diminishing the impact of the original story. The article suggests that this endless continuation without true resolution has made the Star Wars myth less meaningful over time. Characters are never allowed to complete their emotional arcs, victories are temporary, and the galaxy exists in a state of perpetual conflict without resolution.The Future of Star Wars CinemaLooking ahead, the article implies that Star Wars may need to reconsider its approach to big-screen storytelling. The success of Disney+ shows demonstrates that there's an appetite for Star Wars content, but perhaps the franchise needs to differentiate between cinematic and television experiences more clearly. Alternatively, the franchise might benefit from taking bigger creative risks or allowing stories to reach definitive conclusions rather than maintaining an endless status quo. As The Mandalorian and Grogu shows, simply delivering what fans already know and love in shinier packaging may no longer be sufficient to satisfy both critics and audiences on the big screen.

The Record-Breaking Summit A 52-year-old British climber, Kenton Cool, has set a new record as he summited Mount Everest for a 20th time. Cool became the first non-Nepali climber to conquer the world’s highest peak 20 times before dawn on Friday. Cool's Achievement and Its Significance Cool is expected to reach the base camp over the weekend after his latest summit. In a statement carried by the Reuters news agency, he said climbing Mount Everest never gets “any easier or any less frightening. It’s the tallest mountain in the world and with it comes an incredible sense of majesty. “I rely on every bit of experience ⁠I have to move safely in this environment. Standing on the summit for the twentieth time is incredibly special.” The Data Behind the Record Kenton Cool's 20th Everest summit First non-Nepali climber to achieve this feat Cool's first Everest summit was in 2004 He has taken an expedition almost every year since then The Impact on Everest Climbing Cool’s achievement follows on the heels of another record. On Wednesday, more than 270 climbers ascended via Nepal’s southern route, the most in a single day. That came amid calls for action to prevent overcrowding and improve safety. Two Indian climbers were reported on Friday to have reached the peak, but to have died during their descent after they “fell ill”, Nivesh Karki, director at Pioneer Adventure, told the AFP news agency. Authorities are trying to bring the bodies down from the summit. Officials said the incident brings the death toll during this Everest season to five. The Future of Everest Climbing Kami Rita Sherpa, or “Everest Man” climbed the summit for the 32nd time – extending the world record – on Sunday. He expressed concern about the experience of climbers, saying, “The government should regulate this a bit. They should let in only climbers of quality; there should be a limit.”

The LeadHundreds of people in Ireland have taken to the streets to protest what is being described as the country's "George Floyd moment," following the death of a man in police custody. The demonstrations reflect growing public outrage over police conduct and racial justice issues in Ireland.The Event DetailsThe protests erupted after the death of an individual in police custody, which has drawn parallels to the case of George Floyd in the United States. Demonstrators have gathered in major cities across Ireland, demanding accountability and reform in policing practices. The incident has sparked a national conversation about racial justice and police treatment of minorities in Ireland.The Data AnalysisWhile specific crowd size figures were not immediately available, reports indicate that hundreds participated in the demonstrations. The protests have gained significant media attention both locally and internationally, with the "George Floyd moment" comparison becoming a focal point of media coverage.The Impact AnalysisThe protests mark a significant moment in Ireland's social justice movement, highlighting issues of racial inequality and police conduct that have often been overlooked in the predominantly white nation. The demonstrations could lead to increased scrutiny of policing practices and potentially spur policy changes regarding police accountability and racial justice initiatives.The PredictionGoing forward, these protests may lead to sustained activism and policy discussions around policing reform in Ireland. The "George Floyd moment" comparison suggests that Ireland may be experiencing a watershed moment in its approach to racial justice, potentially leading to long-term changes in how the country addresses issues of police conduct and racial inequality.

The Lead: Indigenous Voices Warn of a New Extraction EraIn the arid dry‑tropical forest of La Guajira, Maria Elena Aguilar Uriana points to a dried‑up watering hole and describes how mining has already devastated her community. Now she and other Wayúu leaders fear that the country’s push for wind‑energy is creating a second wave of exploitation.Coal Mining Legacy and Emerging Renewable Projects in La GuajiraFor decades the region has been dominated by Cerrejón, one of the world’s largest open‑pit coal mines, operated by UK‑listed Glencore. The mine has polluted water, spread coal dust over pastures and forced families to relocate. Today, national and corporate plans aim to replace that extractive model with large‑scale wind farms, but Wayúu representatives say the same top‑down approach is being repeated.Scale of the Cerrejón Mine and Planned Wind InfrastructureCerrejón is among the biggest open‑pit coal mines globally, covering thousands of hectares.Renewable‑energy developers are proposing dozens of wind turbines across Wayúu territory, though exact capacity figures have not been disclosed publicly.The projects are promoted as “green” solutions for Colombia’s energy transition, yet community consent processes remain limited.Health, Water Scarcity and Displacement Impacts on Wayúu CommunitiesWayúu testimonies describe chronic respiratory illness, malnutrition and the loss of livestock due to coal dust and dwindling water supplies. José Silva Duarte, president of Nación Wayúu, notes that water is already scarce, and mining consumes vast quantities, forcing families to rely on state‑provided water deliveries or travel long distances to unsafe wells. The combined stress of past mining and looming wind projects has spurred migration to urban centres and across borders, eroding cultural practices built over centuries.Outlook: Negotiating Consent and Sustainable DevelopmentWhile Glencore asserts it monitors air quality and follows Colombian law in land purchases, Wayúu leaders demand genuine participation, protection of water resources and health safeguards before any renewable infrastructure proceeds. The coming months will test whether Colombia can balance its climate ambitions with the rights and wellbeing of its largest Indigenous group.