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The High-Stakes Meeting US President Donald Trump is set to arrive in Beijing on Wednesday evening to discuss the Iran war and other issues with his Chinese counterpart President Xi Jinping. The meeting, initially scheduled for earlier this year but postponed in March due to the US-Israel war on Iran, comes as the US president struggles to contain the fallout from the war, both at home and abroad. The Agenda: Iran and Trade White House Principal Deputy Press Secretary Anna Kelly said an opening ceremony and meeting will be on Thursday morning, and the trip will conclude on Friday. The US plans to host the Chinese leader during a reciprocal visit later this year. A senior administration official told news outlets in an anonymous briefing on Sunday that Trump could "apply pressure" to China on Iran in areas such as oil sales and Tehran's purchase of potential dual-role military-civilian goods. The Economic Impact US Treasury Secretary Scott Bessent last week accused China of "funding" Iran. "Iran is the largest state sponsor of terrorism, and China has been buying 90 percent of their energy, so they are funding the largest state sponsor of terrorism," Bessent told Fox News. Disruptions stemming from the war have disrupted the global economy, with Asian states that depend on imports from the Middle East especially hard hit. The Future of US-China Relations Trump could also bring up China's support for Russia during the talks, along with trade and rare earth minerals, a vital resource for the US tech sector. Business executives from aerospace manufacturer Boeing and a handful of agricultural companies are set to travel with the US delegation. The anonymous administration official said that no change was expected regarding the US stance on Taiwan, a main sticking point in relations between Washington and Beijing.

The Escalation of Violence in Lebanon The Lebanese Health Ministry has reported that Israeli attacks in the past 24 hours have resulted in the deaths of 51 people, including two medical workers. This escalation of violence has raised concerns about the humanitarian situation in Lebanon. Targeting of Medical Personnel The Lebanese Health Ministry accused Israeli forces of directly targeting two points of the Health Authority in Qalawiya and Tibnin, Bint Jbeil district, in two separate raids. This targeting of medical personnel has been widely condemned, with the United Nations reporting that at least 103 Lebanese medical workers have been killed and 230 injured in more than 130 Israeli strikes since March 2. The Humanitarian Crisis The ongoing violence has resulted in a significant humanitarian crisis, with over 1.2 million Lebanese people displaced since March 2. The situation is further complicated by the fact that a ceasefire, brokered by the United States, has been in effect since April 16, but attacks have continued to escalate. International Response The international community has expressed concern about the situation in Lebanon, with many calling for an immediate cessation of hostilities. The United Nations has emphasized the need to protect medical personnel and first responders, as required by international humanitarian law. The Future Outlook The situation in Lebanon remains volatile, with many fearing that the violence will continue to escalate. The international community will be watching closely to see if the ceasefire can be sustained and if efforts can be made to address the humanitarian crisis.

The US Stance on Iran's Enriched Uranium President Donald Trump has warned that the United States will target any Iranian trying to reach the country’s highly enriched uranium, saying that the nuclear material is under constant surveillance by the US military. Trump's Claims on Uranium Surveillance In an interview with the syndicated TV show Full Measure that aired on Sunday, Trump appeared to play down the significance of the uranium, which is believed to be buried under the rubble of nuclear facilities, remaining in Iran for now. “We’ll get that at some point, whenever we want. We have it surveilled,” Trump said. “I did a thing called Space Force, and they are watching. If somebody walked in, they can tell you his name, his address, the number of his badge … If anybody got near the place, we will know about it, and we’ll blow them up.” The Data Analysis: Uranium Stockpile and Enrichment Levels Iran is estimated to have more than 400kg (882lb) of uranium enriched at 60 percent purity. Uranium enrichment is a complex process of isolating and garnering the most radioactive variety – isotope – of the element to produce nuclear fuel. When enriched to around 90 percent purity, uranium can be used to make nuclear weapons. The Impact Analysis: US-Iran Ceasefire Negotiations Iran’s highly enriched uranium is one of the major sticking points between Washington and Tehran in ceasefire negotiations to end the 10-week US-Israel war on Iran. The US wants Iran to transfer the uranium outside the country and completely shut down its nuclear programme, but Tehran has stressed that it will not give up its right to a domestic enrichment programme. The Prediction: Future of US-Iran Relations Despite the truce that came into effect last month, skirmishes have erupted in the Gulf over the past week as the US continues to enforce a siege on Iranian ports amid Tehran’s Hormuz blockade. Iranian state-affiliated news outlets reported on Sunday that Iran has delivered its response to the latest US proposal to end the war to Pakistan, which is mediating the talks. But Trump said the war is not over while reiterating his claim that Iran has been “defeated”.

The Lead In a significant development for international diplomacy, Iran has indicated it may provide formal assurances regarding the use of its nuclear facilities. This potential move comes amid heightened tensions and ongoing negotiations with world powers over the country's nuclear program. The Diplomatic Shift in Iran's Nuclear Policy The reported willingness to offer assurances represents a notable potential shift in Iran's stance on transparency regarding its nuclear activities. While specific details remain limited, such assurances could include commitments about the peaceful nature of nuclear development, enhanced monitoring protocols, or limitations on certain types of nuclear research. Regional and Global Implications This development carries significant weight for regional stability and global non-proliferation efforts. Iran's nuclear program has long been a point of contention in Middle Eastern geopolitics, with neighboring states and international powers expressing concerns about potential weapons development. Any assurances offered by Tehran could potentially ease tensions and create a foundation for renewed diplomatic engagement. The Path Forward for International Negotiations If Iran follows through with providing assurances, it could mark a turning point in stalled negotiations with world powers. Such a move might pave the way for renewed dialogue, potentially leading to updated agreements or modifications to existing frameworks governing Iran's nuclear activities. The international community, particularly European signatories to previous agreements, would likely view such assurances as a positive step toward de-escalation. Future Outlook for Iran's Nuclear Program Looking ahead, the implementation and verification of any assurances will be critical. The coming months will likely see intensified diplomatic efforts to establish concrete mechanisms that address international concerns while respecting Iran's stated right to peaceful nuclear development. The outcome of these developments could reshape the geopolitical landscape of the Middle East and influence global non-proliferation efforts for years to come.

Why CAR T‑Cell Therapy Is Being Called a Game‑ChangerProf Misty Jenkins of the Walter and Eliza Hall Institute describes the therapy as a "game‑changer" because it re‑programs a patient’s own T‑cells to hunt cancer with unprecedented precision. The recent remission of Sam Neill after a Sydney trial has thrust the technology into the public eye, illustrating the potential of a single infusion to achieve durable responses. How the Therapy Works and Recent Clinical SuccessesCAR (chimeric antigen receptor) T‑cell therapy involves three core steps:Extracting a patient’s T‑cells from blood.Genetically engineering them to express a synthetic "GPS" that recognises cancer‑specific proteins.Expanding the modified cells and infusing them back, where they multiply and seek out tumours.Key milestones highlighted in the article:Four CAR T‑cell products approved by Australia’s Therapeutic Goods Administration since 2018, all for blood cancers.Early trials show promise against solid tumours such as gastrointestinal and paediatric brain cancers.In‑vivo approaches are being explored to deliver the therapy via injection, potentially slashing production costs. Cost, Approval Landscape and Funding Milestones in AustraliaCurrent price tag for a single CAR T‑cell course can exceed AU$500,000 per patient.The federal government announced that Carvykti for multiple myeloma will be provided free in public hospitals, a treatment that otherwise costs over AU$200,000.Four approved therapies since 2018 indicate a rapidly expanding regulatory environment, but access remains uneven across states. Implications for Australian Cancer Care and the Global Immunotherapy RaceThe success of CAR T‑cell therapy could reshape Australia’s oncology landscape by:Reducing relapse rates – the therapy can act as a "living drug" that persists in the body.Driving investment in domestic manufacturing capabilities, essential for sovereign supply and cost control.Positioning Australia as a leader in next‑generation immunotherapies, provided research funding keeps pace. What the Next Five Years May Hold for CAR T‑Cell TreatmentsExperts anticipate several developments:Broader approvals for solid‑tumour indications as GPS targeting becomes more precise.Commercial rollout of in‑vivo CAR T‑cell vaccines, potentially lowering treatment costs by an order of magnitude.Policy reforms to integrate CAR T‑cell therapy into standard public‑hospital pathways, ensuring equitable access.While optimism is high, Assoc Prof Maté Biro cautions that "hope is warranted, but so is impatience" – the next wave of breakthroughs will depend on sustained scientific investment and swift regulatory action.

Spirit Airlines announced its abrupt closure on 2 May, citing an unprecedented rise in jet fuel costs as the final blow to an already fragile low‑cost model. The collapse comes as U.S. gasoline prices hit a national average of $4.56 per gallon, up over $1 from the previous year, and some states see prices breach $6 per gallon.Spirit Airlines Halts Operations as Jet Fuel Costs ExplodeThe airline’s app displayed a pop‑up on a Saturday informing customers that all flights were cancelled. Travelers like Chelsea Blackmore, who had booked a $500 round‑trip on Spirit for a Disney cruise, were forced to scramble for alternatives, ultimately paying $800 for a Southwest ticket that lacked even a checked bag.Fuel Price Surge and Ticket Cost InflationU.S. oil prices jumped 30% after the closure of the Strait of Hormuz at the start of the Iran‑related conflict.Jet fuel price spikes added an estimated $500m burden to Spirit’s operating costs.Average ticket prices on routes formerly served by Spirit are expected to rise by 10‑15% due to reduced competition.Ripple Effects Across the U.S. Travel LandscapeFlixBus reported a >30% surge in passengers on 130 routes that mirror former Spirit corridors.Amtrak noted an uptick in ridership, though it cannot isolate the impact of fuel prices.Major carriers such as United and Delta can absorb costs by cutting routes or adding fees, a luxury low‑margin carriers lack.Experts like Lindsay Owens of Groundwork Collaborative liken the airline’s demise to a “gut punch” felt by all Americans facing high energy costs. Senior fellow William McGee warned that even travelers who never used Spirit will see higher fares on overlapping routes.Future of Low‑Cost Travel in a High‑Energy‑Cost EraCalls for a $2.5bn federal assistance package for budget airlines—including Frontier and Avelo—have so far yielded no concrete aid. While President Donald Trump floated the idea of a government buyout, no deal materialised.Industry analysts predict continued fare hikes throughout the summer, with travelers increasingly booking closer to departure dates to chase lower prices—a strategy that may backfire as demand rebounds.Despite the squeeze, vacation demand remains robust; travelers are willing to finance trips on credit cards, prioritising the experience over cost savings.

The Lead: Trump's Fragile Position in Beijing Like an out-of-control wrecking ball, swinging wildly back and forth, Donald Trump smashes up the international order without much thought for the consequences. Lacking coherent strategies, workable plans or consistent aims, he power-trips erratically from one fragile region, tense warzone and complex geopolitical situation to another, leaving misery, confusion and rubble in his wake. The president will bulldoze into another international minefield this week – the fraught standoff between China and Taiwan – when he travels to Beijing for a two-day summit with President Xi Jinping. The Geopolitical Chess Game: Trump's Desperate Need for Xi's Help After a string of humiliating policy implosions over Ukraine, Gaza, Nato, Greenland, and now Iran and Lebanon, needy Trump craves a diplomatic success to flaunt at home. But his hopes of vote-winning trade pacts are overshadowed by his latest war of choice. He needs Xi's promise not to arm Iran if all-out fighting resumes – and Xi's help keeping the strait of Hormuz open as part of a mooted framework peace deal. The weakness of Trump's position going into the summit is fuelling speculation that reduced US support for Taiwan may be Xi's price for playing nice. The Power Dynamics: How Trump's Failures Strengthen Xi's Position Xi knows the Iran war is deeply unpopular with US voters. Trump is universally blamed for pushing up global energy, food and medicine prices. European allies have refused to bail him out, Russia is undeservedly benefiting from inflated oil prices – and poorer countries bear the brunt. Trump is not winning militarily, either, as shown by his half-baked, on-off Project Freedom. For China, Trump is the gift that keeps on giving. Thanks to him, the US is increasingly viewed internationally as an aggressive potential enemy or unreliable friend, much given over to treachery. The Taiwan Factor: Xi's Ultimate Priority Xi's top external priority is not the Middle East. It is the unification of communist China with a de facto independent, democratic Taiwan – a personal legacy project that he has repeatedly threatened to pursue by force. Pentagon planners believe China's ever-expanding military could be ready to launch an invasion next year. Taiwan's forces are vastly outnumbered, while its fractious political parties are as divided as ever about increased defense spending and the wisdom or not of seeking closer ties with Beijing. The Iran Conflict: A Double-Edged Sword for China The downside for Xi is the negative impact of the war on energy prices, global trade and export demand at a time when China's economy is already struggling. Last year, about 80% of Iranian oil shipments were bought by China – shipments the US navy is now blocking. So far, Beijing has largely managed to offset supply shortfalls from the Gulf by drawing on reserves, capitalising on green energy and buying more oil from countries such as Brazil and Russia. But for the world's largest importer of crude oil, safe and reliable navigation through the strait of Hormuz is critical. The Strategic Implications: US Military Resources Diverted from Asia The Iran impasse is drawing US forces away from Asia – it now has two aircraft carrier strike groups in the Middle East – and reducing its military capacity to defend Taiwan and regional allies from future Chinese aggression. China is urging both sides to embrace a negotiated settlement. It hosted direct talks last week with Iran's foreign minister, Abbas Araghchi, and is backing Pakistani intermediaries. Recalling China's successful 2023 fence-mending between Saudi Arabia and Tehran, anxious Gulf states are counting, like Trump, on Beijing's ability to influence its Iranian ally. The Future Outlook: A Potential Taiwan Compromise? Trump seems aware of this risk. He wrote to Xi last month, asking him not to supply weaponry to Tehran – and said he had received assurances China would not do so. But the Foundation for Defense of Democracies, a conservative US research institute, claims China already provides Iran with dual-use precursor chemicals for its ballistic missiles, satellite intelligence about US military movements, assets and bases, and help with sanctions evasion and money laundering. For a man who likes to boast he holds all the cards, the US president may find himself seriously short of trumps when he sits down with Xi.

The Quest for a Winless, Point‑Free Season While point deductions are a common way for clubs to end a campaign on zero, a far smaller group have hit the rock bottom purely by losing every single fixture. The Guardian’s Q&A; explores which sides have actually finished a full season with 0 points on the books. Record‑Breaking Zero‑Point Campaigns Across the Globe Antigua Barracuda – 2013 United Soccer League (USL) season: 26 matches, 0 wins, 0 draws, 0 points. The club operated on a shoestring, with unpaid players and long minivan trips to games. Woodford United – Southern League Division One Central, 2012‑13: 42 league defeats, 0 points. Budget cuts forced youth coaches to field a makeshift squad, resulting in a record 185 goals conceded. Longford AFC – Gloucestershire Northern Senior League Division Two, 2015‑16: 30 losses, 0 points. Even a cameo from former England star Stuart Pearce could not spark a goal. Gibraltar Phoenix – Gibraltar Premier Division, 2013‑14: 14 games, 0 points in the league’s inaugural UEFA‑recognised season. Grêmio Barueri – Campeonato Paulista, 2016: 19 matches, 0 points despite playing in a 31,000‑seat stadium. Glasgow Women FC – Scottish Women’s Premier League, 2022‑23: 22 defeats, 0 points, 6 goals scored. Billericay Town Women – Women’s National League Southern Premier Division, 2022‑23: 0 points in a similar fate. Yeni Malatyaspor – Turkish TFF First League, 2022‑23: 38 straight losses, 0 points amid financial collapse. Numbers That Define the Infamy The raw statistics underline the severity of these campaigns. The longest winless streak recorded in the list is 42 matches (Woodford United), while the highest goals‑against tally sits at 185 in the same season. In the United States, the 26‑game USL season of Antigua Barracuda remains the only professional league where a club finished with a perfect loss record. What Zero‑Point Seasons Reveal About Club Viability Across continents, the common thread is financial distress. Unpaid wages, inadequate travel budgets, and stadiums that outsize the fanbase all contributed to on‑field collapse. These seasons often trigger relegation, loss of league licences, or outright dissolution, highlighting how fragile lower‑tier football ecosystems can be. Will Modern Football Prevent Another Point‑Free Year? Governance reforms—stricter licensing, financial fair‑play checks, and emergency funding mechanisms—aim to stop clubs from reaching such extremes. However, as long as revenue gaps persist between elite and grassroots levels, the risk of another zero‑point season remains, especially in leagues with limited oversight.

The Forgotten OriginsThe last time the US hosted the men's World Cup in 1994, many Americans viewed soccer as a game they watched their kids play on Saturday mornings, not the world's most beloved sport. Thirty-two years later, the sport has exploded in popularity and the USA have become a regular fixture at World Cups. But many people don't realize the US's World Cup history extends all the way back to the first tournament staged – when the US men had their best-ever finish, reaching the semi-finals.The tale of those connected with the US team is often bleak, but it's also more deeply rooted and richer than is often appreciated. As US soccer fans turn their attention to the future of the sport, we revisit four often overlooked moments – and one widely celebrated kick – of the USA's early World Cup history.Tragedy and TriumphSix of the 16-man squad who went to Uruguay for the first World Cup were British, but all played their club football in the US, an indication of the strength of domestic league at the time. A 3-0 win over Belgium in their opening game – which shared with France v Mexico the honor of being the first-ever game at a World Cup – was followed by a 3-0 win over Paraguay in which Bert Patenaude scored the first World Cup hat-trick – although it was only in November 2006, 32 years after his death, that the disputed second of his three goals was finally confirmed as having been scored by the Fall River striker.Substitutions were not introduced to the World Cup until 1970, meaning injuries could have a huge influence on the outcome of a game, reducing a side to 10 men or fewer. And injuries severely afflicted the USA in their semi-final against Argentina. The goalkeeper Jimmy Douglas struggled on with a twisted knee and the midfielder Ralph Tracy missed the whole of the second half after fracturing his right leg. Andy Auld, meanwhile, was temporarily blinded after the physio Jack Coll dropped a bottle of chloroform as he tended to the forward's split lip. After battling gamely, the USA conceded three late goals and lost 6-1.The Mystery of Donelli and SchroederThe USA entered the 1934 tournament late and were very fortunate that Fifa agreed to let them play a qualifier against Mexico in Italy shortly before the first round. The USA won 4-2 in front of 10,000 spectators in Rome, all their goals being scored by Aldo "Buff" Donelli, who would later become a coach in the NFL with the Pittsburgh Steelers and the Cleveland Rams. Mexico blamed their defeat on the fact their journey to Italy had taken 15 days, while the USA had managed to cross the Atlantic in just nine. In the first round, the USA lost 7-1 to the eventual champions Italy; if the journey hardly seemed worth it for just two games, they were at least better off than poor Mexico, who went straight home after their qualifying defeat.The US team manager in Italy was Elmer Schroeder, who had also been part of the backroom staff in 1930. In 1932 he had been elected as the first US-born president of the United States Football Association (the body that is now US Soccer) and although he did not seek re-election in 1934, he led the national squad at the 1936 Olympic Games as well, and remained manager of Philadelphia Germans until 1949. Four years later, his badly beaten body, bound with the cord from the window-blinds, was found on the bed in his apartment. Although nobody was ever convicted of his homicide, it seems probable that he was murdered by a serial killer who preyed on gay men in Philadelphia in the early 1950s.The Disappeared HeroThe USA withdrew from a playoff against the Dutch East Indies for the 1938 World Cup but did qualify for 1950. It was at that tournament in Brazil that they achieved perhaps their most notable result, beating England 1-0 in Belo Horizonte, one of the greatest shocks in World Cup history. The only goal was scored by Joe Gaetjens, diverting in a shot from Walter Bahr. Gaetjens had been born in Haiti and was awaiting US citizenship at the time; early US soccer history was based on a liberal immigration policy.Gaetjens never got his citizenship, returning to Haiti soon after. His family were distant relations by marriage of Louis Déjoie, who lost the 1957 presidential election to the notorious François "Papa Doc" Duvalier. In 1964, when Duvalier declared himself dictator for life, most of Gaetjens's family fled the country.Gaetjens, though, had had little involvement in politics and decided to remain. He was soon arrested by the Tonton Macoute, Duvalier's secret police, and never seen again. It's believed he was murdered at the Fort Dimanche prison, but his body has never been found.The Shot Heard Around the WorldThe modern history of the USA at the World Cup begins with Paul Caligiuri's "shot heard around the world" in Port of Spain in November 1989 – a 30-yard left-foot volley that secured a 1-0 win over Trinidad and Tobago and booked the USA's place at Italia 90. Qualification was seen as an essential part of preparation for hosting the tournament in 1994, for reasons of credibility if nothing else. The USA lost all three games they played in Italy, but, with the exception of 2018, they've been at every World Cup since.