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The Journey from Prototype to ClearanceBuilding a medical device is fundamentally different from standard software development. This week on Build Mode, host Isabelle Johannessen sat down with Robhy Bustami, co-founder and CEO of BioticsAI, to discuss the arduous path from a $100,000 prototype to FDA clearance. Bustami, a Startup Battlefield winner, detailed how his team is building an AI copilot for ultrasound designed to detect fetal abnormalities. The conversation revealed that the traditional startup mantra of 'move fast and break things' is obsolete in the medical sector, replaced by a necessity for extreme precision and coordination.Market Validation and Resource AllocationThe episode provides a strategic look at the 'data' driving medtech success. BioticsAI's recognition as a Startup Battlefield winner serves as a key validation of their technology's potential. However, Bustami emphasized that the primary data point for founders is not just market traction, but the successful navigation of complex regulatory pathways. This requires a significant reallocation of resources—shifting focus from rapid feature deployment to ensuring safety, reliability, and compliance with FDA standards.Shifting the MedTech CultureThe core impact of this discussion lies in the cultural shift it highlights for the industry. As timelines for FDA approval remain uncertain, the ability to maintain team morale and investor confidence becomes a critical operational metric. Bustami noted that building in a regulated industry requires a foundation of trust rather than speed. This signals a broader trend where medtech startups must balance the pressure of hyper-growth with the ethical and legal responsibilities of patient safety.The Future of AI in Healthcare RegulationLooking ahead, the medtech landscape will likely see a consolidation of companies that prioritize long-term compliance over short-term hype. As more AI copilots enter the market, the winners will be those founders who master the art of 'slow and steady' innovation. The next wave of medical breakthroughs will depend not just on algorithmic superiority, but on the ability to build sustainable organizations capable of weathering the regulatory storm.

The Challenges of FDA Approval Surviving the long road to FDA approval isn’t just about building great technology — it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. Lessons from BioticsAI This week on Build Mode, Isabelle Johannessen sits down with Robhy Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100,000 prototype to FDA clearance, Bustami shares what it actually takes to build in one of the most regulated industries in the world. Building a Medtech Startup In this episode, they break down what it really looks like to build a medtech startup, including where you can’t “move fast and break things” and that every milestone takes time, coordination, and trust. Key Takeaways Team motivation is crucial during the long FDA approval process Finding the right investors is essential for medtech startups Adaptability is key when dealing with uncertain timelines Future Outlook As the medtech industry continues to evolve, startups like BioticsAI will play a critical role in shaping the future of healthcare technology. With the right approach and mindset, these companies can overcome the challenges of FDA approval and make a lasting impact.

The Health Crisis of a Jailed Opposition LeaderJailed Tunisian opposition leader Rached Ghannouchi has been urgently transferred to a hospital after experiencing a sharp deterioration in his health, according to his party Ennahdha. The 84-year-old former speaker of parliament and head of the Ennahdha party has been imprisoned since April 2023 in what his supporters and international rights groups describe as a politically motivated campaign to crush dissent.In a statement on Thursday, Ennahdha's media and communications office confirmed that prison authorities were forced to transfer Ghannouchi to hospital for treatment and continuous medical observation over the coming days. The party did not provide specific details regarding his current medical condition, but noted that he suffers from chronic illnesses that require constant family care and attention due to his advanced age.Multiple Prison Sentences and Arbitrary DetentionGhannouchi's hospitalization comes amid multiple prison sentences totaling over 25 years. He was initially arrested in April 2023 on charges of incitement and sentenced to one year in prison. In February 2024, a financial corruption court sentenced him to three years over accusations that his party received foreign contributions – a charge Ennahdha vehemently denied. In February 2025, he was handed a 22-year prison sentence on charges including plotting against state security."In light of this dangerous development, the movement renews its demand for the immediate release of Mr Rached Ghannouchi, considering him arbitrarily detained," the Ennahdha statement read. The party pointed to a 2024 decision by a United Nations committee of experts, which concluded that Ghannouchi is being prosecuted for his freedom of opinion and expression, and that the charges against him lack any legal or factual basis.Widening Crackdown on Political OppositionGhannouchi's situation is part of a broader crackdown on political opposition orchestrated by President Kais Saied. Elected in 2019, Saied – a former law professor – suspended the Tunisian parliament in 2021 and subsequently dissolved the legislature to rule by decree. He later pushed through a controversial referendum on a new constitution that vastly expanded presidential powers, which the opposition has described as a coup.Since consolidating power, Saied's government has targeted numerous opposition figures, journalists, lawyers, and activists. In November 2025, Jawhar Ben Mbarek, cofounder of the National Salvation Front, was hospitalised due to severe dehydration during a hunger strike protesting his detention. Shortly after, prominent opposition figure Ayachi Hammami was arrested in December 2025 to enforce a five-year prison sentence following a mass trial of opposition members.International Condemnation and Human Rights ConcernsHuman rights organisations, including Human Rights Watch (HRW) and Amnesty International, have consistently condemned the arrests. In a 2025 report, HRW stated that Tunisia's government had turned arbitrary detention into a cornerstone of repressive policy."Saied's government has returned the country to an era of political prisoners, robbing Tunisians of hard-won civil liberties," said Bassam Khawaja, HRW's deputy Middle East and North Africa director. Despite international criticism, Saied has denied accusations of authoritarianism, maintaining that his actions are necessary to fight corruption, rescue the country from political chaos, and hold those he labels as "terrorists" accountable.Future Outlook for Tunisia's Political LandscapeGhannouchi's hospitalization has intensified international scrutiny on Tunisia's human rights situation. With the health of the highest-profile opposition figure deteriorating, pressure is mounting on President Saied's government to address concerns about arbitrary detention and political prisoners. The Ennahdha party has emphasized that "the natural place for Mr Rached Ghannouchi is to be free in his home among his family," citing his constitutional right to necessary healthcare and international treaties ratified by Tunisia.As Tunisia approaches potential political transitions, the treatment of opposition figures like Ghannouchi will likely remain a critical point of contention both domestically and internationally. The international community continues to monitor the situation closely, with human rights organizations likely to further document and report on developments in the coming weeks and months.

The Human Cost of War on Childbirth In the war-torn Gaza Strip, the already dangerous process of childbirth has become increasingly perilous. Duha Abu Yousef, 24, sits on a mattress in her half-destroyed apartment, struggling to care for her newborn after an emergency caesarean section performed due to severe anemia. Her story represents a growing crisis in maternal healthcare as caesarean sections rise while conditions for recovery deteriorate. The Surge in Surgical Deliveries According to Dr. Fathi al-Dahdouh, head of obstetrics at Gaza City's Al Helou International Hospital, caesarean sections have increased by approximately 2% since the conflict began, now constituting a quarter of all births. This surge is driven by multiple factors: difficulty in travel to healthcare facilities, pregnancy as a form of "compensation for loss" among women who have lost children, and injuries from bombardments that necessitate immediate surgical intervention. Dr. Ruba al-Madhoun, an obstetrician-gynaecologist at the International Medical Corps field hospital, explains that many pregnant women arrive in critical condition with injuries causing complications like placental abruptions. Shortages in medical equipment, including continuous fetal monitoring devices and labor-inducing medications, have further increased reliance on surgical deliveries. Medical Statistics and System Collapse Caesarean sections now account for 25% of all births in Gaza 2% increase in surgical deliveries since before the war Rising trend of older women (late 30s to 40+) becoming pregnant despite risks Growing number of surgical wound infections due to antibiotic shortages Lack of laboratory capacity to identify bacteria in infections These statistics reflect a healthcare system stretched beyond capacity. The heavy pressure on hospital wards and staff shortages have made caesarean deliveries at times the fastest and safest available option, despite the inherent risks of surgical procedures in resource-limited settings. Compounded Health Crisis The dangers of caesarean sections in Gaza extend beyond the operating room. Displacement, malnutrition, and deficiencies in essential nutrients directly impair wound healing. Overcrowded tents and contaminated water significantly increase infection risks, both for caesarean wounds and overall health. "This is further compounded by severe overcrowding in wards, where multiple patients often share a single room," explains Dr. al-Madhoun. The lack of appropriate antibiotics and laboratory capacity to identify bacteria has led to a growing number of surgical wound infections. Sanaa al-Shukri's case exemplifies these challenges. Returning to the hospital 10 days after giving birth due to a recurrent infection in her caesarean wound, she described the excruciating pain when doctors reopened the wound without anesthesia to clean out accumulated pus. "I felt like my soul was leaving my body," she recounted. Future Outlook for Maternal Healthcare As the conflict in Gaza continues, the outlook for maternal healthcare remains dire. The combination of increased surgical deliveries, deteriorating living conditions, and overwhelmed healthcare facilities creates a dangerous cycle that threatens the lives of both mothers and newborns. Medical professionals warn that without significant improvements in nutrition, sanitation, and medical supplies, infection rates will continue to rise, potentially leading to long-term health complications for mothers and higher infant mortality rates. The international community faces an urgent need to address not just the immediate medical needs but also the underlying conditions that make childbirth in Gaza increasingly hazardous.

The Worsening Health Outlook in the UKAccording to a new study, people in the UK are now spending fewer years in good health compared to a decade ago. This concerning trend highlights potential challenges facing the nation's healthcare system and public health initiatives.The Rational Explanation for Haunted House SensationsResearch suggests that the eerie feelings often experienced in old houses may not be supernatural but rather caused by everyday sounds from boilers and other mechanical systems. This scientific explanation offers a rational perspective on commonly reported paranormal experiences.Human Achievement Meets Technological Innovation in Marathon RunningKenya's Sabastian Sawe has made history by becoming the first person to run a marathon in under two hours, setting a new world record with a time of 01:59:30. This remarkable achievement was accomplished while wearing Adidas Adizero Adios Pro Evo 3 trainers, showcasing the intersection of human potential and technological advancement in sports.Global Fertility Trends and Their Societal ImplicationsThe podcast also promotes a miniseries called 'Shrinking States' that examines the global decline in fertility rates. This series offers insights into how changing birth patterns worldwide may impact future societies and economies.

The AI Funding Race Heats UpInvestor interest in Anthropic has reached a feverish pitch, with multiple preemptive offers to raise fresh capital of around $50 billion at a valuation in the $850 billion to $900 billion range, according to sources familiar with the matter. The maker of the Claude AI assistant is reportedly finding it difficult to resist the pressure to secure more funding in what could be its final round of private fundraising before a potential IPO.Massive Valuation SurgeThe potential round would represent a dramatic increase from Anthropic's last funding in February, which valued the company at $380 billion. If the company proceeds with another fundraise at the terms described, it will not only more than double its valuation but also match or surpass that of its chief rival, OpenAI, which closed a record-breaking $122 billion round at an $852 billion post-money valuation in February.Revenue Growth Fuels Investor DemandAnthropic announced this month that its annual revenue run rate has surpassed $30 billion, a dramatic increase from roughly $9 billion at the end of 2025. The company's run rate is currently closer to $40 billion, according to sources with knowledge of the company's financials. This rapid growth shows no sign of slowing, with investors clamoring to get into the round. One institutional investor prepared to commit as much as $5 billion has yet to secure a meeting with Anthropic CFO Krishna Rao.AI Coding Capabilities Driving RevenueA large portion of Anthropic's revenue is driven by its AI coding capabilities, specifically through its Claude Code and Cowork platforms. Many investors believe the company is only scratching the surface of its potential, given the massive opportunity to expand its offerings into new industries, including finance, life sciences, and healthcare.Final Decision Expected in MayThe company is expected to make a definitive decision on the round and its valuation at a board meeting in May, according to one source familiar with the matter. This timing suggests Anthropic is carefully considering its options as it approaches what could be its final private fundraising round before a potential IPO, with the company declining to comment on the reports.

Record global military spending surged to $2.88 trillion in 2025, a 2.9% increase from the previous year, equating to roughly $350 per person worldwide. The United States remains the dominant spender, while per‑capita spikes in Qatar, Israel and Ukraine reshape the arms landscape.The United States Maintains Its Unmatched Military BudgetThe United States spent $954 billion in 2025, out‑spending the next six countries combined. Since 1949 the U.S. has allocated at least $53.5 trillion to defence, representing 51.5% of the global cumulative total of over $100 trillion.Top five spenders in 2025: United States ($954 bn), China ($336 bn), Russia ($190 bn), Germany ($114 bn), India ($92 bn) – together 58% of world spending.Spending Numbers: $2.88 Trillion and the Top Five NationsGlobal defence outlays have risen from $1.69 trillion in 2016 to $2.88 trillion in 2025 – a 41% jump in less than a decade.Per‑capita extremes illustrate divergent trajectories:Qatar: $5,428 per person (2022), a 340% rise since 2006.Israel: $5,108 per person, up 276%.Norway: $3,040 per person, up 181%.Ukraine: 3,387% surge to $2,197 per person in 2025.Geopolitical Ripple Effects of Accelerating Arms ExpenditureArms trade is concentrated in a handful of exporters:United States – 39% of global sales ($115 bn).Russia – 13% ($40 bn).France – 9.3% ($28 bn).China – 5.5% ($16 bn).Germany – 5.5% ($16 bn).Between 2020‑2024 the Pentagon awarded $2.4 trillion in contracts, with $771 bn funneled to five firms: Lockheed Martin, RTX, Boeing, General Dynamics and Northrop Grumman.Future Trajectory: AI‑Driven Defence and the Next Spending SurgeModern militarisation is merging traditional platforms with artificial intelligence, autonomous systems and cyber capabilities. In 2023 the U.S. Department of Defense granted $200 million contracts each to OpenAI, xAI and Anthropic to embed generative AI into defence operations, while Palantir’s AI‑assisted targeting is already in use.If AI integration accelerates, defence budgets are likely to climb further, pressuring civilian sectors such as healthcare and education that already receive the majority of public spending in most countries.

The Climb for a Cause A remarkable feat of endurance and compassion has been achieved as a mountaineer reached the summit of Mount Everest, the world's highest peak, with a mission to support Palestinian children. This climb is not just about reaching the top; it's about bringing attention to the struggles and hardships faced by young people in Palestine. Challenges Faced by Palestinian Children Limited access to education and healthcare Impact of conflict on mental and physical well-being Need for international support and awareness The Power of Climbing for a Cause This mountaineer's journey to the top of Everest serves as a powerful reminder of the impact one person can have on the lives of others. By undertaking this challenging climb, the mountaineer aims to inspire others to join the cause and make a difference in the lives of Palestinian children. A Call to Action As the mountaineer celebrates this incredible achievement, the focus now shifts to continuing the support for Palestinian children. This climb is a call to action for people around the world to come together and make a positive impact on the lives of those who need it most. The Future of Support for Palestinian Children The success of this climb will hopefully pave the way for more initiatives and support for Palestinian children. It highlights the importance of international solidarity and the need for continued efforts to address the challenges faced by young people in the region.

U.S. military engagements spanning 76 years have amassed a staggering human and financial cost, now resurfacing as the Iran‑U.S. conflict inflates daily spending and household bills.The Expanding Human Toll Across Seven DecadesFrom Korea to the present Iran war, U.S. actions have claimed millions of civilian lives and tens of thousands of service members. Notable figures include:2,461 U.S. soldiers killed and at least 20,000 wounded in the two‑decade Afghanistan war.Since February 28, 3,375 Iranians reported dead and over 200 U.S. combat‑related casualties.Brown University’s Cost of War Project estimates ≈940,000 deaths across post‑9/11 conflict zones.Veterans like Jeffery Camp and Naveed Shah stress that the burden falls on those who never made the strategic decisions.Billions in Daily War Spending: From Korea to IranThe Pentagon disclosed an initial $11.3 bn outlay on munitions in the first six days of the Iran war, with daily costs later estimated at $1 bn and now under $100 m during the cease‑fire.Comparative averages illustrate the scale:Afghanistan (20 years): $2.3 trillion total, > $300 m per day.Iraq (8 years): $2 trillion total, ≈ $684 m per day.Analyst Mark Cancian notes that long‑range munitions such as $2.5 m Tomahawk missiles drive early‑war spikes.Long‑Term Economic Burdens on U.S. HouseholdsBeyond the battlefield, the war’s ripple effects hit everyday Americans. A Brown University Climate Solutions Lab study quantifies a $27.8 bn consumer burden from higher petrol and diesel prices—roughly $200 per household.Fuel costs have risen nearly 40 %, from $2.90 to $4.10 per gallon, squeezing budgets already stretched by health‑care inflation (e.g., a 35 % rise in out‑of‑pocket expenses reported by Marwa Jadoon).Veterans’ obligations loom large: the Cost of War Project projects at least $2.2 trillion in U.S. healthcare commitments over the next 30 years.Future Fiscal Pressures: Veterans Care and Energy InflationWith public disapproval at a historic high—60 % of Americans now oppose the Iran strikes—the political appetite for continued spending wanes, yet the fiscal commitments remain.Key forward‑looking considerations:How the U.S. will fund the projected $2.2 trillion veteran‑care bill without raising taxes.Potential policy shifts to curb energy price pass‑throughs as fuel remains a politically sensitive commodity.Whether the “rally‑around‑the‑flag” effect can re‑emerge in future conflicts, influencing budget allocations.Understanding the intertwined human and economic costs is essential for policymakers, investors, and citizens confronting the legacy of 76 years of U.S. warfare.