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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Unseen Toll of War The conflict in Mali has had a profound impact on the mental health of its citizens. Beyond the physical destruction and loss of life, the war has left a lasting legacy of psychological trauma. Living with Trauma Survivors of the war often struggle with anxiety, depression, and post-traumatic stress disorder (PTSD). These conditions can make everyday tasks challenging and affect relationships with family and friends. The Need for Support Addressing the mental health needs of Malians affected by the war is essential for the country's recovery. This includes providing access to mental health services and supporting community-based initiatives. A Path Forward By acknowledging the mental trauma caused by the war, Mali can begin to heal and rebuild. It is crucial for the international community to provide support and resources to help the country address this critical issue.

The LeadAs we celebrate Miles Davis's centenary, his 1957 film soundtrack "Ascenseur pour l'Échafaud" is being repackaged with restored audio, offering a fresh look at the jazz legend's innovative approach to film scoring and improvisation. This mostly improvised soundtrack, created over one night in a Paris studio, showcases Davis's unique harmonic openness that would later influence his masterpiece "Kind of Blue."The Creative Process Behind the SoundtrackComposed by Davis from little more than a handful of chords, this music was mostly improvised straight to a screen showing budding New Wave director Louis Malle's crime thriller "Ascenseur pour l'Échafaud" (Lift to the Scaffold), over one long night in a Paris studio in December 1957. His fine local quartet included expat New York bebop drummer Kenny Clarke, and their harmonic openness created a spacey, ethereal soundworld for a story following two lovers who think they've committed the perfect murder of an inconvenient husband, and the mishaps, farces, ecstasies and fears that populate the long night of their undoing.The Musical Landscape of NoirDreamily sensual sounds mirror misplaced hopes; there are car-chase scurries (Miles's fast-bop horn virtuosity was formidable in this period), desolately bluesy accompaniments to actor Jeanne Moreau's confused wandering in search of her partner, bar-room clamour in the trumpet/tenor-sax counterpoint between Miles and saxist Barney Wilen – but all the music stands alone, without images. A quiet slow-burn, but simmering with all of Miles Davis's timelessly extraordinary light and heat.Jazz Tributes and Contemporary ConnectionsThis month marks Miles's centenary, and a clamour of celebrations of a musical life that led him to be dubbed (by Duke Ellington, allegedly) the "Picasso of jazz" for the many styles he explored. Alongside the reissue of "Ascenseur pour l'Échafaud," other artists are paying tribute: Norwegian guitarist Hedvig Mollestad's power-trio Weejuns nods to Miles Davis' 1969 "Bitches Brew" with "Bitches Blues"; guitarist Jeff Parker unveils fascinating ways of emerging from minimalism to lyricism; and Jason Miles, a former Miles Davis keyboardist, revisits that groove-centric era in his own personal way.The Legacy of ImprovisationWhen Miles Davis was dying in September 1991, an invisible, neighbouring trumpet player began playing homages to Miles' voice-like, blues-inflected melodies instead. It was a poignant personal tribute to a unique instrumental sound, and a unique imagination, that had profoundly enriched 20th-century music. The reissue of "Ascenseur pour l'Échafaud" continues this legacy, showing how Davis's approach to improvisation and harmonic openness continues to influence musicians today.

The Resurgence of Religious Disputes in India From mosques to temples, old religious battles are back in India’s courts. A law passed after the Babri Masjid dispute was meant to stop exactly this. But new claims are moving forward again, as Hindu nationalism grows and many Muslims fear that the protections once promised to them are slipping away. The Growing Concern of Hindu Nationalism The rise of Hindu nationalism in India has led to an increase in religious disputes, with many Muslims feeling that their rights and protections are being eroded. The Babri Masjid dispute, which was a major flashpoint in Indian politics, was supposed to be a wake-up call for the government to take steps to prevent such conflicts. The Impact on Minority Communities The resurgence of religious disputes in India has significant implications for minority communities, particularly Muslims. Many Muslims fear that they are being targeted and that their rights are being ignored. The government has been accused of not doing enough to protect minority rights and of emboldening Hindu nationalist groups. The Future Outlook The future outlook for India is uncertain, with many experts warning that the rise of Hindu nationalism could lead to further polarization and conflict. The government needs to take steps to address the concerns of minority communities and to prevent further escalation of religious disputes. Yashraj Sharma (@yashjournals), Al Jazeera reporter Episode credits: This episode was produced by Marcos Bartolome and Sari el-Khalili with Spencer Cline, Noor Wazwaz, Tuleen Barakat, and our host, Malika Bilal. It was edited by Tamara Khandaker. Our sound designer is Alex Roldan. Our video editors are Hisham Abu Salah and Mohannad al-Melhemm. Alexandra Locke is The Take’s executive producer. Connect with us: @AJEPodcasts on X, Instagram, Facebook, and YouTube

The Comeback of Manuel Neuer Bayern Munich's Manuel Neuer has come out of international retirement to compete in next month's World Cup after being named as the starting goalkeeper in Germany coach Julian Nagelsmann's squad for the tournament. Nagelsmann's Decision Nagelsmann made the decision after having long labelled Hoffenheim's Oliver Baumann as his first-choice keeper. "Yes, I plan with that [with Neuer as number one]," Nagelsmann told a press conference. "The main task was to nominate the best three keepers. So we decided that these three are part of that." Neuer's Career Revival The 40-year-old Neuer, who last competed for Germany at Euro 2024 before his international retirement, is now set to play in his fifth successive World Cup, joining an elite group of football players with five or more tournaments. Neuer, a 2014 World Cup winner, enjoyed a solid season with champions Bayern, who could win the domestic double with victory over VfB Stuttgart in the German Cup final on Saturday. Germany's World Cup Squad There were few other major surprises in Nagelsmann's 26-man squad for the tournament starting next month. But the coach also called up Bayern's teenage player Lennart Karl, who enjoyed a meteoric rise this season, as well as Nadiem Amiri and Leroy Sane, who both had outside chances of earning a spot. Germany's World Cup Goals Germany, who face Curacao, Ecuador and Ivory Coast in Group E at the World Cup, have set their sights on a fifth title after shock first-round exits in the past two editions in 2018 and 2022. "The statement stands," Nagelsmann said. "We want to become world champions. Every player who is nominated needs to show it now every day." Full Germany Squad Goalkeepers: Manuel Neuer, Oliver Baumann, Alexander Nubel Defenders: Nico Schlotterbeck, David Raum, Nathaniel Brown, Jonathan Tah, Waldemar Anton, Pascal Gross, Joshua Kimmich, Felix Nmecha, Malick Thiaw, Aleksandar Pavlovic, Antonio Rudiger, Angelo Stiller Midfielders/Forwards: Leon Goretzka, Maximilian Beier, Jamal Musiala, Nadiem Amiri, Jamie Leweling, Kai Havertz, Lennart Karl, Florian Wirtz, Deniz Undav, Nick Woltemade, Leroy Sane

The LeadEleven weeks after the start of the Iran war, the Strait of Hormuz has remained closed to naval traffic, bleeding the global economy far beyond the Gulf. Iran's Islamic Revolutionary Guard Corps (IRGC) maintains an iron grip over this narrow, strategic waterway, while a corresponding United States naval blockade on Iranian ports has failed to reopen it.Before the war began, between 120 and 140 ships travelled through the strait each day, about half of them oil tankers carrying some 20 million barrels of oil between them. Now, only a few vessels whose owners have negotiated with the IRGC are permitted to pass.The Strategic Control of HormuzOn Wednesday, Iran said it coordinated the transit of 26 vessels through the Strait of Hormuz in 24 hours, two days after announcing the formation of the Persian Gulf Strait Authority (PGSA), a new body to provide "real-time updates" on operations in the strait.Since the announcement of a temporary ceasefire between the US and Iran in April, Iran has been working on formalising a mechanism to charge a transit fee from ships crossing the critical chokepoint, through which 20 percent of the world's oil and liquefied natural gas (LNG) are shipped during peacetime.Tehran has reportedly already charged fees as high as $2m per ship for transit since the war started. Even though countries opposing Tehran say this is illegal, it may still be less expensive than the overall cost of the closure of the strait each day.The Economic Cost of BlockadeNearly one-fifth of global oil and LNG exports were shipped by Gulf producers through the Strait of Hormuz before the US and Israel bombed Iran on February 28, triggering the Iranian closure of the waterway. The strait is the only waterway linking Gulf producers to the open ocean – there is no other route through which they can ship exports.About 20.3 million barrels per day of oil passed through the Strait of Hormuz in peacetime – nearly 27 percent of global maritime oil trade. The lion's share of that crude went to Asian markets.Global LNG trade has been similarly hard hit. On the day before the war broke out, Brent crude – the global benchmark for oil prices – closed at $72.48 per barrel. After Iran closed the waterway on March 4 and began attacks on vessels attempting to sail through, traffic came to a standstill, stranding about 2,000 ships on either side of the strait.In terms of lost oil revenues, this amounts to $114.8bn of losses per day. About 10 billion cubic feet of LNG per day also used to pass through the strait, worth a further $7.8bn.The Cost-Benefit Analysis of Transit FeesFor hundreds of ships stranded in the Gulf with thousands of sailors on board, the cost of remaining anchored is steep, including crew wages, loan repayments, repair and management, coupled with inflated war risk premiums.In turn, Iran has reportedly been charging up to $2m for authorisation to pass. Experts say many will see this as worthwhile purely in terms of monetary cost."There is no doubt that paying Iran is cheaper than a continuous blockade because a sitting tanker bleeds money," said Nader Habibi, an Iranian American economist."It makes sense from an economic point of view, but it is not politically feasible," he added. "The companies are under pressure from the US sanctions and not to make arrangements with Iran. This is not just a purely economic cost-benefit analysis, but long-term considerations that are taken into account."International Legal PerspectivesInternational law protects free transit through strategic waters such as natural straits like Hormuz, barring countries from imposing passage tolls even where the waterways fall entirely into territorial waters, like in the case of Hormuz.However, services such as security controls, inspections and insurance regimes can be charged for. Chargeable fees also partly depend on whether a waterway is a man-made passageway or a natural one.These are three different precedents in maritime traffic flow:Panama Canal: An artificial waterway connecting the Atlantic and Pacific oceans. Vessels pass through a unique system of locks that raise and lower vessels across elevated terrain. Since Panama built, maintains and operates the canal, it can charge transit fees based on vessel size, cargo capacity and booking priority. These range from several hundred thousand dollars per transit to some slots sold for millions of dollars.Suez Canal: Another artificial canal, linking the Mediterranean and Red seas. Egypt charges transit fees for the use of canal infrastructure, maintenance and traffic management services through the narrow waterway. Container ships and oil tankers pay from several hundred thousand dollars to more than one million dollars per voyage.Turkiye's Bosporus Strait and Dardanelles: These are different because they are natural straits, rather than man-made canals. Turkiye charges for navigation-related services such as lighthouse operations, rescue readiness, medical support and traffic management – and tightly controls ship scheduling and navigation.Regional Cooperation PossibilitiesIran's newly-formed PGSA published a new map of Hormuz, stretching from Kuh-e Mubarak in Iran to south of Fujairah, in the UAE, at the eastern entrance of the strait, and from the tip of Qeshm Island to Umm al-Quwain at the western entrance.Given how the Iran war has spilled over into the Gulf region – with the UAE taking the brunt of Iranian strikes – economist Mohammad Reza Farzanegan said "regional cooperation with Iran is the most realistic path to stable transit through the Strait of Hormuz."The UAE, Oman, Qatar and Iran will have to work together because their economies require it, he argued. A workable arrangement could include a joint maritime authority, shared monitoring, emergency coordination, environmental protection and service-based contributions for maintaining safe passage."This would give Iran a recognised role in the security of the waterway while giving Persian Gulf economies more predictability," Farzanegan added. "Such a framework is also more realistic than relying on external military enforcement, which has been more a source of trouble for these states."The Future OutlookWhile it may seem that the economics of the closure of the strait are currently skewed towards Iran, Aniseh Tabrizi, an associate fellow on the Middle East and North Africa Programme at think tank Chatham House, noted that "the economics by itself is not going to be the driver to change calculation or move from the current standpoint."She emphasized that Iran and the US need to reach a "diplomatic compromise, with other calculations linked in to the economic factor", before there can be an end to the energy supply crisis.Farzanegan added that if the world expects stable access to the Strait of Hormuz, then paying Iran could well be accepted as the price of keeping the vital waterway predictable. "From an economic perspective, a negotiated transit arrangement [with Iran] now makes more sense than continued closure," he concluded.

Executive Summary: Activists Mobilize a Cross‑Border ConvoyOn 21 May 2026, a coalition of activists began a land convoy from Libya toward the Gaza Strip, aiming to transport essential humanitarian supplies amid the ongoing blockade.Logistics of the Libya‑to‑Gaza Aid ConvoyDeparture point: Tripoli, LibyaRoute: Through Egypt’s Sinai Peninsula, crossing the Rafah borderSupplies: Food, medical kits, water purification units totaling ≈5,000 kgParticipants: Roughly 30 vehicles and over 100 volunteersFinancial and Material Scale of the OperationThe convoy’s cargo represents an estimated value of $2.3 million, funded by a mix of private donations and crowd‑sourced campaigns.Regional Implications for Humanitarian AccessThe initiative challenges the prevailing restrictions imposed by Israel and Egypt, potentially setting a precedent for civil‑society‑driven relief pathways in conflict zones.Outlook: Prospects for Continued Aid CorridorsIf the convoy reaches Gaza, it could inspire similar cross‑border efforts, prompting diplomatic negotiations to formalize humanitarian corridors and reshape aid logistics in the Middle East.

Senegal’s national team has confirmed a 28‑man squad for the 2026 FIFA World Cup, with marquee names Sadio Mane and Kalidou Koulibaly leading a blend of seasoned stars and youthful prospects.Senegal Announces 28‑Man Roster Featuring Mane and KoulibalyCoach Pape Thiaw revealed the list on Thursday, noting that two players will be cut before the final deadline at the end of May. The selection reflects a strategic mix of experience, athleticism, and depth across all positions.Squad Composition and Player StatisticsGoalkeepers: Edouard Mendy, Yehvann Diouf, Mory DiawDefenders: Kalidou Koulibaly, Krepin Diatta, Antoine Mendy, Abdoulaye Seck, Ilay Camara, Moussa Niakhate, Mamadou Sarr, El‑Hadji Malick Diouf, Moustapha Mbow, Ismail JakobsMidfielders: Idrissa Gueye, Habib Diarra, Pape Matar Sarr, Pape Gueye, Lamine Camara, Pathe Ciss, Bara NdiayeForwards: Sadio Mane (34, 53 goals in 126 caps), Bamba Dieng, Iliman Ndiaye, Nicolas Jackson, Assane Diao, Ibrahim Mbaye, Cherif Ndiaye, Ismaila SarrThe squad retains the all‑time leading scorer Mane and the experienced centre‑back Koulibaly, while also integrating promising talents such as 18‑year‑old Bayern midfielder Bara Ndiaye.Implications for African Representation and Tournament ProspectsSenegal entered the tournament as the most potent African qualifier, having topped the recent Africa Cup of Nations. Their Group I draw pits them against France (June 16, New Jersey), Norway (June 22), and Iraq (June 26), offering a challenging path but also a chance to replicate their 2002 quarter‑final run.The inclusion of both veteran leaders and dynamic youngsters signals a clear intent to advance beyond the group stage, potentially reshaping the perception of African teams at the World Cup.What to Expect from Senegal in the 2026 World CupAnalysts anticipate that Mane will spearhead the attack, supported by pacey wingers Ismaila Sarr and Nicolas Jackson. Defensively, Koulibaly provides stability, while the midfield depth—featuring Gueye and emerging talents—offers tactical flexibility.If the squad can stay injury‑free and integrate the new call‑ups quickly, Senegal could challenge for a knockout‑stage berth, aiming to surpass their 2018 group‑stage exit and 2022 round‑of‑16 finish.

The Growing Concern of Forced Disappearances Ecuador has been grappling with a disturbing trend of forced disappearances, which has left many families in a state of anguish and uncertainty. The issue has gained significant attention from human rights organizations and local authorities, who are working to uncover the truth behind these incidents. The Extent of the Problem While exact numbers are difficult to come by, reports indicate that numerous individuals have gone missing in recent times. The disappearances have been reported across various regions of Ecuador, sparking fears of a larger, more complex issue at play. Investigations and Concerns Authorities in Ecuador have launched investigations into the disappearances, but the lack of concrete information has fueled concerns about the extent of the problem and the potential involvement of organized crime or other malicious actors. The Human Impact The forced disappearances have had a profound impact on the families of the missing individuals, who are often left with little information about the fate of their loved ones. Human rights groups have emphasized the need for urgent action to address the issue and ensure that those responsible are held accountable. Seeking Answers and Justice As the situation continues to unfold, there is a growing demand for transparency and justice. The Ecuadorian government, along with international organizations, must work together to uncover the truth behind these forced disappearances and take concrete steps to prevent future incidents.