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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

BBC Two’s three‑part series ‘Michael Jackson: An American Tragedy’ attempts to map the arc of the King of Pop from a Midwestern child prodigy to a global phenomenon whose legacy is still contested. Released ahead of the family‑approved biopic Michael, the documentary does not promise fresh revelations; instead, it seeks to place the singer’s meteoric fame, legal controversies and post‑mortem financial empire within a single narrative. The first episode, titled Fame, foregrounds Jackson’s musical genius while also exposing the fraught dynamics of his family life. Interviews with siblings and childhood acquaintances depict a household where “six bunk beds in one room” were the norm, and where fear of their father, Joe Jackson, loomed large. La Toyia Jackson’s recollection that “Michael had a fear of my father – we all did” underscores the pressure that shaped his early years. In The Reckoning, the series shifts to the period of criminal investigations and media scrutiny. Former spiritual adviser Rabbi Shmuley Boteach describes the tragedy as a man who, despite unparalleled attention, remained “utterly lonely.” Prosecutor Ron Zonen argues that the sheer scale of the Jackson enterprise eclipsed the pursuit of justice, noting the obviousness of the abuse allegations in his view. The episode also revisits the 2003 Martin Bashir documentary, which Boteach recalls as a “shock” that contributed to the star’s eventual downfall. The final installment, The Resurrection, examines the attempts to revive Jackson’s career, his sudden death, and the ripple effects of the 2019 Leaving Neverland documentary. The review notes that the allegations have reshaped public perception to the point where many, including the reviewer, find it difficult to engage with his music. The series concludes that the ongoing legal battles—seven alleged victims are currently suing the estate—represent “the most extraordinary effort to uncancel someone in history.” While the documentary assembles an extensive roster of interviewees—family members, former managers, record executives, and even Donald Trump—it occasionally suffers from an overly broad brushstroke that blurs moral clarity. The reviewer acknowledges the valiant effort to strike a middle ground but questions whether such balance is sufficient for a story marked by “wild extremes.” Overall, the series provides a comprehensive, if not groundbreaking, overview of Jackson’s complex narrative, serving as a timely companion piece to the upcoming biopic and a reminder that the conversation around his legacy remains far from settled. Michael Jackson: An American Tragedy is currently streaming on iPlayer.

Copenhagen returns to the London stage under Michael Longhurst’s direction at Hampstead Theatre, a timing the reviewer calls “terrifyingly timely.” The three‑hander dramatizes the 1941 encounter between Danish physicist Niels Bohr (played by Richard Schiff) and German scientist Werner Heisenberg (Damien Molony), set against the looming threat of Hitler’s nuclear ambitions. The production draws unsettling parallels to contemporary politics, invoking Donald Trump’s recent threats toward Iran as a modern echo of the era’s extremist rhetoric. This resonance, the reviewer notes, amplifies the play’s relevance alongside the theatre’s downstairs offering, ROI (Return on Investment), which also interrogates the morality of scientific discovery. Visually, Joanna Scotcher’s set is a striking, non‑realist circle surrounded by water—a subtle nod to the “heavy water” used in Nazi nuclear research and a poignant reminder of the personal tragedy that befell one of Bohr’s sons. The second half’s dense scientific dialogue is rendered accessible, though the reviewer argues it sometimes falls short of fully unpacking the deeper metaphors embedded in the science. Performance-wise, the age gap between Bohr and Heisenberg (Bohr being sixteen years senior) hampers the on‑stage chemistry. Schiff’s portrayal of the seasoned Bohr occasionally stumbles over lines, while Molony’s Heisenberg comes across as a brooding, almost adolescent figure. In contrast, Alex Kingston’s turn as Bohr’s wife and editor, Margrethe, provides the emotional core, shouldering much of the play’s affective weight. Thematically, the drama wrestles with the question of whether scientists bear a moral duty beyond their research. Heisenberg’s famed uncertainty principle is employed as a metaphor for the psychological ambiguity surrounding their historic meeting. Yet the script conspicuously omits any direct reference to the bombings of Hiroshima and Nagasaki, focusing instead on the fear of a Nazi atomic weapon and sidestepping the United States’ own nuclear legacy. While the production boasts compelling aesthetics and a thought‑provoking premise, the reviewer finds moments of sluggish pacing and a missed opportunity to confront the irony of overlooking the U.S. bombings, especially as contemporary concerns about American military assertiveness rise. The show runs at Hampstead Theatre, London until 2 May.

The UK hospitality sector is reeling from a triple whammy of rising costs, including increased minimum wage, business rates, and energy prices. This has put immense pressure on businesses, particularly pubs and hotels, to maintain profitability.Nick Evans, co-owner of the Old Crown Coaching Inn in Oxfordshire, exemplifies the struggles faced by many in the industry. Despite a rich history dating back to 1645, Evans is finding it challenging to make ends meet. The pub's annual revenue stands at £1.4m, but rising costs, including a £350,000 wage bill and £80,000 energy bill, are eating into profits.The latest blow to the industry came on April 1, with increases in the minimum wage and business rates. Evans notes that the wage bill will rise to nearly £370,000, and the business rates increase will add another £24,000 to the bill. This comes on top of surging energy prices due to the Iran crisis, which will further exacerbate the cost burden.Evans argues that the national insurance change is misogynistic, as it disincentivizes employers from hiring part-time workers, often mothers seeking extra income. He also believes that the minimum wage increase will price young people out of the market, as employers may opt to hire adults for a pound more.Kate Nicholls, chair of UK Hospitality, warns that one in five businesses fear they may not survive the next 12 months. She emphasizes that the sector cannot absorb any more cost increases, and hikes will simply be passed through to consumers, driving inflation and hitting jobs.For now, Evans and his co-owner, Mike Webb, are seeking a more lenient payment plan for their VAT bill from HMRC. As Evans says, 'It’s tough, tough, tough.' The future of many hospitality businesses hangs in the balance as they struggle to navigate these unprecedented challenges.

Formula One has endured a turbulent opening to the season under its new regulations. The sport's governing body, the FIA, is now proposing changes to address safety concerns and driver dissatisfaction. Nikolas Tombazis, the single-seater director for the FIA, is at the heart of the process and is confident that F1 can adapt successfully.Tombazis acknowledges that the new rules have provoked a strong reaction, with some drivers expressing discontent. Oliver Bearman's 190mph crash at Suzuka has raised concerns about the safety of the new regulations, and the FIA is taking a cautious approach to making changes. "Every accident at high speed is always a little bit of a shock," Tombazis says.The FIA is discussing potential changes with teams, powerunit manufacturers, and the commercial rights holder. Meetings are scheduled for April 20 and May 3 to decide on changes to the regulations, which could include adjustments to the parameters of energy recovery and deployment. Tombazis emphasizes that safety is the top priority and that the goal is to find a balance between safety and competitiveness.The new regulations have been a topic of debate, with some drivers, such as Lando Norris and Max Verstappen, expressing dissatisfaction with the current formula. The FIA is working to address these concerns while also ensuring that the sport remains safe and competitive. "We're not expecting people to sugarcoat their comments," Tombazis says, but he is hopeful that a broad consensus can be reached.

János Bődey's photograph of two elderly ladies dressed as bride and groom in a Hungarian retirement home has captured the essence of joy and love in old age. The image is part of his series Carnival at the Retirement Home, which showcases the fulfilling lives of pensioners who have overcome difficulties.In Hungary, the average pension is approximately £500 a month, making it challenging for retirees to afford leisure, culture, or travel. Additionally, the health of Hungarian pensioners often falls short of Western standards, and securing a spot in a retirement home can be a lengthy process.Bődey's subjects, Magdolna, 87, and Irén, 86, have lived with their husbands for over 50 and 62 years, respectively, until their spouses passed away. They attribute their long and happy lives to a combination of good genes, an active lifestyle, and a healthy marriage.The photographer's series aims to serve as a role model for both peers and the middle generation, demonstrating that it's possible to lead a fulfilling life in old age. The elderly ladies recommend a healthy, active life with plenty of walking and traveling, as well as avoiding debt.Bődey's work is a departure from his usual coverage of conflicts and social issues. He finds inspiration in the happiness and playfulness of the carnival celebrations, which begin in February to mark the end of winter.The photographer's experience has taught him the importance of preparing for retirement by gathering emotional and financial resources, setting goals, and being creative. His series has been shortlisted for the Sony World Photography Awards 2026 and will be exhibited at Somerset House in London from April 17 to May 4.

Anthropic, a San Francisco-based AI startup, has announced that its latest AI model, Claude Mythos, has proven highly effective in exposing software weaknesses. The model has identified thousands of vulnerabilities in commonly used applications, many of which have no patch or fix available.According to Mike Krieger of Anthropic Labs, the company has decided not to release Mythos to the public due to concerns about its potential misuse by hackers. Instead, Anthropic is collaborating with cybersecurity specialists and engineers in the open-source community to utilize the model as a defensive tool.The oldest vulnerability uncovered by Mythos dates back 27 years, and none were previously noticed by their creators. Anthropic has shared a version of Mythos with cybersecurity companies CrowdStrike and Palo Alto Networks, as well as with Amazon, Apple, and Microsoft, in a project dubbed “Glasswing”.“AI models have reached a level of coding capability where they can surpass all but the most skilled humans at finding and exploiting software vulnerabilities,” Anthropic said in a blog post. “The fallout – for economies, public safety, and national security – could be severe.”The project aims to protect critical infrastructure from cyber threats, with approximately 40 organizations involved in the design, maintenance, or operation of computer systems. Anthropic is providing about $100m worth of computing resources for the mission.

In a thrilling Champions League matchup, Arsenal claimed a crucial victory in Lisbon, with Kai Havertz scoring the winning goal in injury time after Gabriel Martinelli drew the defense. This win comes after Arsenal lost their previous two matches, making it a significant turnaround for the team.Elsewhere, Bayern Munich secured a win at the Bernabéu, with Trent Alexander-Arnold's perfect ball setting up Kylian Mbappé's goal. This result keeps the tie very much alive, with both teams still in contention.The podcast also discusses a big Easter of Football League action and pays tribute to Aaron Ramsey. Listeners can find Football Weekly on various platforms, including Instagram, TikTok, and YouTube.

The author's concerns about AI were previously localized to her household income and the job market, but after reading the alarming article, she now worries about the bigger picture. The investigation reveals that AI is a power story as much as a technology story, with Sam Altman at its center.The chatbot, ChatGPT, created by OpenAI, was asked to summarize the key findings of the article, but its response was deemed neutral and lacking in substance. A human-powered summary, on the other hand, describes Altman as a corporate grifter whose actions could have world-ending consequences.The article highlights the dangers of AI, including the alignment problem, where AI uses its superior intelligence to trick human engineers and outmaneuver them. This could lead to AI seizing control of critical infrastructure, such as the energy grid, stock market, or nuclear arsenal.Elon Musk's 2014 tweet about AI being potentially more dangerous than nukes is recalled, and Altman's own blog post from 2015 warning about the risks of superhuman machine intelligence is mentioned. However, since OpenAI became mainly a for-profit entity, Altman has stopped discussing these risks and now sells the technology as a portal to utopia.The author concludes that the greatest danger we face is from a failure of imagination in understanding the vast gap between personal AI use and its potential use by governments, military regimes, or rogue actors. The chatbot's response to the author's concern about entering the permanent underclass is seen as wholly witless and without threat, highlighting the need for greater awareness and oversight of AI.