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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

The recent 10-day space mission of the Artemis II crew has garnered attention, but the true test of endurance might not be in space, but in an office setting. Commander Reid Wiseman, mission specialists Christina Koch and Jeremy Hansen, and pilot Victor Glover spent time in a capsule described as “not much bigger than a family tent”. While they navigated the challenges of confined space, their experience pales in comparison to the complexities of office politics.Anyone who has worked in an office can attest that surviving with colleagues in a confined environment is a significant test of endurance. The Artemis II crew had to get along without time off, which would be challenging even for experienced professionals. The quirks and habits of colleagues can become amplified in such settings, leading to increased tension and stress.The writer of this piece reflects on their own experience in a mundane office job at a stationery firm. They recall the boredom and impotence that led to a fixation on trivial matters, such as a dispute over a window being open or closed. This petty feud became an all-consuming battle that defined their time at the office.The writer notes that, unlike the Artemis II crew, they had the option to leave the office at the end of the day. However, their obsession with the window dispute led them to spend more time at their desk, avoiding breaks and social interactions. The comparison between the crew's space test and the writer's office experience highlights the universal challenges of working with others.Ultimately, the Artemis II crew's achievement is impressive, but it also underscores the importance of interpersonal skills and conflict resolution in any confined or high-stress environment. As the writer concludes, surviving an office job can be just as challenging as surviving in space.

The Artemis II mission has achieved a historic milestone with a successful Pacific splashdown, marking the first time humans have traveled to the moon in over 50 years. The mission's dramatic conclusion followed a voyage that unveiled previously unseen expanses of the lunar far side, a total solar eclipse, and a celestial display of planets. The four astronauts – commander Reid Wiseman, pilot Victor Glover, Christina Koch, and Canada's Jeremy Hansen – surfaced from their floating capsule into daylight off San Diego's coast. The lunar explorers' journey was a significant step towards establishing a permanent human presence on the moon. The Orion capsule, named Integrity, executed its entire descent automatically, striking the atmosphere at Mach 33 – 33 times the speed of sound – a scorching velocity unseen since the Apollo era. The capsule endured thousands of degrees during re-entry, with the heat shield performing crucially during this phase. The successful mission paves the way for NASA's planned moon landing by another crew in two years, followed by establishing a permanent lunar base within the decade. NASA Administrator Jared Isaacman praised the crew, saying, “These were the ambassadors from humanity to the stars that we sent out there right now, and I can’t imagine a better crew.” NASA's Mission Control erupted in celebration, with hundreds pouring in from the back support rooms. “We did it,” NASA’s Lori Glaze rejoiced at a news conference. “Welcome to our moonshot.”

NASA's Artemis II mission has achieved a major milestone with the successful return of its four astronauts to Earth, marking the end of a 10-day journey that took them farther into space than any human has gone before. The crew, comprising NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, along with Canadian astronaut Jeremy Hansen, completed a parachute landing in the Pacific Ocean off the coast of California at 5:07 pm Pacific time (00:07 GMT). This mission is a critical step towards future lunar exploration, particularly Artemis IV, which aims to land astronauts on the lunar surface for the first time since the Apollo era. The Artemis II mission tested essential technologies for deep space travel, including the performance of the Orion capsule's heat shield, navigation systems, and life-support technology. The mission also marked several historic firsts: Glover became the first person of color to travel around the moon, Koch the first woman, and Hansen the first non-American. During their journey, the crew witnessed a solar eclipse and meteorite impacts, and shared vivid descriptions of the lunar surface. Mission commander Wiseman reflected on the mission's significance, stating, "what we really hoped in our soul is that we could, for just a moment, have the world pause — and remember that this is a beautiful planet in a very special place in our universe".

The recent return of the Artemis II mission to Earth has been hailed as a major achievement for NASA, marking the first crewed mission to the moon in over 50 years. The mission, which included astronauts Reid Wiseman, Victor Glover, Christina Koch, and Jeremy Hansen, broke a distance record and demonstrated the capability to sustain human life beyond lower-Earth orbit.However, the celebration has been overshadowed by proposed budget cuts to NASA, with Donald Trump announcing a 23% reduction in funding, including a 46% cut for space science initiatives. Critics argue that these cuts, described as 'extinction-level', would severely impact NASA's ability to achieve its ambitious goals in deep space exploration.NASA Administrator Jared Isaacman defended the budget proposal, stating that the levels are sufficient to meet mission priorities. However, Casey Dreier of the Planetary Society expressed concerns, highlighting the contradiction between the budget proposal and previous statements by NASA leadership.The Artemis program faces significant challenges ahead, including the development of a permanent lunar base. Despite these concerns, NASA is already looking ahead to Artemis III, scheduled for next year, which will test human lunar landing systems.Artemis II has been hailed as a crucial step in the US space program, providing a significant advantage in the new space race with China. The mission's success has brought renewed attention to the importance of continued investment in space exploration and the need for a stable and supportive budget.

The latest offering from writer Theo Jamieson and director Adam Lenson is a boldly conceived musical that thrusts a turbulent romance into a sci‑fi framework. The story follows a young astronaut, Daniel, who vanishes from his shuttle with barely enough fuel, prompting a quest to uncover the motives behind his reckless flight.Stuart Thompson (as Daniel) and Poppy Gilbert (as Emily) anchor the piece with performances that are both visceral and nuanced. Their chemistry captures the push‑pull of a relationship scarred by childhood bullying, parental betrayal, and a shared history of trauma, delivering songs that soar and hit hard.Visually, the production leans heavily on interstellar projections that transform the stage into a shifting cosmos, while the score oscillates between Sondheim‑style wit and full‑blown symphonic passages. This combination creates an epic sense of strangeness that distinguishes Flyby from more conventional West End fare.However, the narrative’s fragmented structure hampers its emotional payoff. The non‑chronological storytelling leaves critical gaps, and the metaphor of being "stranded in space" feels over‑extended—especially with the protagonist’s surname, Defoe, a thin nod to Robinson Crusoe. The three narrators, played by Simbi Akande, Gina Beck, and Rupert Young, often drift into digressive asides that dilute the central arc.Despite these flaws, moments of brilliance emerge, particularly in the musical’s treatment of mental‑health themes. The show hints at the potential to join the ranks of modern theatre successes like Next to Normal and Dear Evan Hansen, should its structural rough edges be smoothed.The production is currently staged at Southwark Playhouse, Borough, London and will run through 16 May. Audiences seeking a daring blend of emotional intensity and cosmic spectacle will find Flyby a compelling, if imperfect, experience.

The Artemis II mission came to a close on Friday night with a gentle Pacific Ocean splashdown, marking a significant achievement in space exploration. The Orion capsule, carrying four astronauts, touched down off the coast of San Diego at 5:07 pm PT, bringing an end to a 10-day lunar odyssey.This mission marked a historic moment as the three Americans and one Canadian became the first people to travel beyond lower Earth orbit since the final Apollo mission in December 1972. The successful test flight around the far side of the moon appears to have met all its objectives, paving the way for future missions.The crew, consisting of Reid Wiseman, Victor Glover, Christina Koch, and Jeremy Hansen, traveled 252,756 miles from Earth, setting a new record for the farthest human spaceflight. Koch became the only woman to have traveled to the moon and back, while Hansen became the first non-American, and Glover became the first person of color to achieve this feat.During their mission, the astronauts evaluated Orion's life support systems, radiation detectors, next-generation spacesuits, and tested other operations crucial to future deep-space missions. The mission also included a successful lunar flyby, with the crew capturing stunning video footage and high-resolution images of the lunar surface.The splashdown was a complex process, involving a succession of deployments of Orion's 11 parachutes at various altitudes to slow the spacecraft to a safe landing speed. The Coast Guard and NASA recovery crews were positioned to cover a large landing zone, ensuring a smooth recovery process.This mission marks a significant step forward for NASA's Artemis program, which aims to return humans to the moon by 2028. The success of Artemis II brings us closer to achieving this goal and paves the way for future missions to the moon and beyond.

NASA unveiled a historic photograph showing Earth disappearing behind the Moon’s edge, taken by the Artemis II crew aboard the Orion capsule during a record‑setting lunar flyby. The image, dubbed “Earthset,” arrives more than 57 years after the famed Apollo 8 Earthrise shot that first revealed our planet from lunar orbit.The four‑person crew—American astronauts Reid Wiseman, Christina Koch, Victor Glover and Canadian astronaut Jeremy Hansen—captured the view on April 6, 2026, deliberately echoing Bill Anders’ December 1968 photograph. Their mission, part of NASA’s broader Artemis program, is designed to lay the groundwork for a 2028 crewed Moon landing.After sharing the image on X, the White House highlighted its significance, noting it as “the first photo from the far side of the Moon, showing humanity from the other side.” The administration also posted a separate NASA picture of a solar eclipse observed during the flyby, describing it as “a view few in human history have ever witnessed.”Beyond the Earthset, the Artemis II astronauts have provided detailed observations of lunar topography and reported witnessing a solar eclipse when the Moon passed in front of the Sun—an event rarely seen from that perspective.The original Earthrise photograph, taken during Apollo 8’s ten lunar orbits, has been celebrated as one of the most influential images ever captured, featuring in Life magazine’s 2003 compilation “100 Photographs That Changed the World.” The new Earthset image adds a contemporary counterpart, reinforcing the enduring power of space photography to shape public perception of Earth’s place in the cosmos.

Barcelona secured a 2‑0 advantage over Atletico Madrid at the Metropolitano, setting up a high‑stakes Champions League quarter‑final second leg. The win followed a 2‑1 league victory against the same opponents, where Marcus Rashford and Robert Lewandowski scored late goals to clinch the La Liga title. After the match, Diego Simeone approached Hansi Flick with a reminder to return, underscoring the rivalry that will see the teams clash three times in ten days. The upcoming return fixture at Camp Nou promises a tougher battle than the opening encounter. Rashford’s performance was described by Spanish outlets as “hyperactive” and an “exhibition of speed.” He generated seven shots in the first hour alone, including a disallowed goal, multiple attempts saved by goalkeeper Juan Musso, and a free‑kick that struck the bar. His relentless wing play forced the opposition to defend deeper, highlighting his impact beyond the scoreboard. Statistically, Rashford has become Barcelona’s most prolific loanee this season: five goals and four assists in ten Champions League games, and he has reached double figures for both goals and assists across all competitions – a first for any player in Spain this campaign. The loan, secured for €30 million (£26 million) with an option to buy, was initially motivated by Barcelona’s need for a versatile forward who could operate across the front line. The club previously pursued Nico Williams and Luis Díaz, but Rashford’s deal offered a quicker, more economical solution amid La Liga’s salary‑cap constraints. While he started the season as a backup, injuries to Raphinha and form dips from Ferran Torres and Lewandowski opened opportunities. Coach Flick has primarily deployed Rashford on the left flank, though he was briefly positioned as a centre‑forward during the Atletico match. Despite his contributions, Flick cautions that Rashford must improve his defensive work‑rate, a point emphasized by the coach before the game: “We know Marcus is fantastic with the ball, but defending is also part of the game.” Historically, overturning a 2‑0 first‑leg deficit in the Champions League is rare – only one team has succeeded. This reality adds pressure on Barcelona to protect their lead, while Simeone’s side will aim to exploit any complacency. Looking ahead, the club faces a strategic decision: whether to activate the €30 million buy clause and secure Rashford permanently. United have labelled the fee as non‑negotiable, but Barcelona’s limited budget and the desire to convert a successful loan into a long‑term asset make the negotiation critical. Rashford himself remains optimistic, stating he enjoys the new environment and culture in Catalonia. As the second leg looms, his “hyperactive” energy and willingness to take responsibility could prove decisive for Barcelona’s quest to reach the Champions League semi‑finals.