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Breakthrough Cancer Drug Reveals Hidden TumorsA smart drug that stops cancer cells "hiding" from treatment can shrink tumours by at least 30% in six of the world's most common forms of the disease, according to early trial results. While immunotherapy treatments have improved survival rates for many patients, their effectiveness can stall or fail when tumour cells hide and then spread.How the Smart Drug WorksResearchers in Oxford have developed a drug designed to stop cancer cells concealing themselves from the immune system, allowing immunotherapy treatments to identify and destroy them. In a trial spanning the UK, France, Spain and Australia, 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers were given the experimental drug, GRWD5769, alongside the immunotherapy treatment cemiplimab.The smart drug was able to remove "invisibility cloaks" from tumour cells, exposing them to the parts of the immune system that attack infections and diseases. This allowed the cemiplimab immunotherapy to pinpoint and destroy the cancer.Trial Results Across Cancer TypesResearchers, led by the Christie NHS foundation trust in Manchester, England, found that tumours shrank in 26 patients. Of those, 15 experienced tumour reductions of at least 30%. All participants had previously failed to respond to treatment, and most had no options left when they joined the study.GRWD5769 was shown to shrink tumours in all six cancer types included in the trial. The drug halted progression of the disease for at least six months in 18% of cervical cancer patients, 32% of liver cancer patients, 36% of bladder cancer patients, 38% of those with neck and head cancer, and more than half of bowel (51%) and lung (55%) cancer patients.Significance for Cancer TreatmentImmunotherapy enlists T-cells – immune system cells that attack infections and diseases – to hunt and destroy cancer. Although it has revolutionised cancer care, it fails in about two-thirds of patients. This is because immunotherapy struggles when tumours hide from the immune system.Tumours can evade the immune system by manipulating an enzyme called ERAP1 (endoplasmic reticulum aminopeptidase 1). By altering this enzyme, cancer cells can hide from a patient's T-cells. GRWD5769 solves this problem by inhibiting ERAP1, which removes cancer's invisibility cloak and makes tumour cells visible to T-cells that could not previously find them.Future Outlook for Cancer TreatmentThe findings were presented at the American Society of Clinical Oncology's annual meeting in Chicago, the world's largest cancer conference. Prof Fiona Thistlethwaite, the principal investigator, noted: "For a drug that is given as a tablet, this is very impressive. It's early days, and we need further studies, but this is a new drug with a new mechanism that clearly helps immunotherapy perform more effectively."The tablets, which were developed by Oxford-based Greywolf Therapeutics and were tolerated well by patients. The trial remains ongoing, with a larger study planned. Cancer Research UK's research information lead, Dr Samuel Godfrey, noted: "Immunotherapy has transformed treatment for some cancers but it doesn't yet work for everyone. This trial seems to show how this new drug could make immunotherapy more effective, including in some cases where immunotherapy had previously failed."

The Evolution of World Cup UpsetsThis year, the biggest ever World Cup will feature 48 teams, an increase from 32, opening up the tournament to even more upsets, shocks and surprises. The vagaries of the World Cup draw have given rise to classic underdog victories over the years, from an amateur USA team's shock defeat of the then-favourites England in 1950 onwards. But what does the data tell us about upsets in football's modern era?Starting from the launch of the Fifa men's world ranking system in 1993, we have analysed each World Cup match in which an underdog beat a higher-ranked team, along with the ranking disparity between the teams: the bigger the gap, the higher the "upset score", and the larger the circle in the graphics below. Upsets are marked in red, while matches decided on penalties are represented with a white border.USA 1994: Regional Rivalries and Bulgarian BrillianceThis World Cup was characterised by a consistent stream of upsets, particularly in the group stages, with a couple of surprise regional rivalries including Belgium (Fifa ranking 27) triumphing over the Netherlands (2) and Saudi Arabia (34), in their World Cup debut, seeing off Morocco (28).The first World Cup after the dissolution of the USSR featured the first appearance by a unified German team and arguably the tournament's most iconic underdog moment, when a header by Yordan Letchkov secured Bulgaria's (29) victory over top-ranked Germany (1) in the quarter-finals. Bulgaria enjoyed a strong competition overall, including beating Argentina (8) in the group stages and a surprise round of 16 win against Mexico (16) in a penalty shootout.France 1998: Upsets All the Way

The Lead: England's Test Redemption at Lord's Lord's hosts its 150th Test match this week as England seeks redemption following a disappointing Ashes winter. The match against New Zealand presents both familiar challenges and intriguing storylines, with new faces in the England lineup and the ongoing tension between franchise cricket and international commitments. The Event Details: Franchise Cricket's Growing Influence The International Cricket Council has expressed concern about the growing expanse of franchise cricket and resolved to form a committee to assess harmonization of franchise cricket with the international calendar. This comes as England prepares for their Test match with several players unavailable due to IPL commitments. The Data Analysis: Player Availability and Team Selection England's squad for the Test against New Zealand includes debutant Emilio Gay at opener and the return of Ollie Robinson. However, key players like Jofra Archer and Jacob Bethell are unavailable due to their IPL commitments with Rajasthan Royals and Royal Challengers Bangalore respectively. In contrast, New Zealand's Rachin Ravindra secured an early release from his franchise to focus on Test cricket. The Impact Analysis: The Franchise vs. Test Cricket Dilemma England's cricket system appears increasingly influenced by franchise cricket, with the ECB unable to withdraw players from The Hundred for reasons other than injury. This creates a situation where central contracts are effectively valid for only nine months a year, with rest periods needing to be scheduled around franchise commitments. The appointment of Andrew Flintoff as head coach of Sydney Thunder further highlights the blurring lines between international and franchise cricket. The Prediction: Navigating Cricket's Evolving Landscape As Ben Stokes acknowledges, the current cricket landscape forces teams and individuals into uneasy compromises. While the ICC committee may eventually propose solutions, the fundamental tension between lucrative franchise leagues and traditional Test cricket is likely to persist. England's ability to balance these competing priorities will be crucial to their success in both formats moving forward.

The Historic 150th Test at Lord'sLord's Cricket Ground in London is making history this week by hosting its 150th Test match, becoming the first ground in the world to reach this significant milestone. While other venues like Melbourne's MCG follow with 118 Tests, Lord's has maintained its privileged position through hosting two games annually this century. Despite being a late starter to Test cricket (its first match was in July 1884), long after venues like Melbourne, Sydney, The Oval, and Old Trafford, Lord's has cemented its status as cricket's most iconic venue.The Three Lord's of LondonInterestingly, there are actually three Lord's in London. The original ground is now buried under Dorset Square near Marylebone station, while another lies beneath the Lisson Grove moorings on the Regents canal. The current world-famous ground on Wellington Road was rented in the 19th century from the Eyre family, who made their fortune in wine and slavery. This historic patch of land has remained cricket's spiritual home for nearly two centuries.The Cultural Significance of Lord'sDespite its stuffy atmosphere, expensive tickets, and sometimes stifling rules, Lord's holds a special place in cricket lovers' hearts. The venue offers a unique thrill that connects spectators with centuries of cricket history. At Lord's, fans don't just share the game with fellow spectators but with the hundreds of thousands who watched great players before them. Honours boards display heroes' names, museum exhibits showcase their bats, library shelves hold their books, and plaques commemorate their feats.The Evolution of Lord's Cricket GroundLord's wasn't always the established institution it is today. In its early years, the ground held as many pony races and stone-picking contests as cricket matches. The MCC (Marylebone Cricket Club) has faced financial challenges throughout its history, requiring bailouts from wealthier members and even considering building houses on the outfield. The venue has also had to defend against urban encroachment, with red brick walls constructed to guard against the surrounding city and developers attempting to claim the tunnels beneath the ground.Lord's: More Than Just CricketWhile known as the 'Home of Cricket,' Lord's is actually the home of the MCC, a private club that has historically governed the sport. Like Augusta National in golf, it represents a private club running a publicly beloved event. After losing its governing role in 1993, the MCC has been searching for a new identity. Today, it runs charitable programs, hosts special matches, offers tours, and even fields its own professional team in the London Spirit.Five of the Most Memorable Tests at Lord'sEngland v Australia, 1896: England won by six wickets in WG Grace's last Test at Lord's. The crowd was so packed they spilled onto the field, and Australia was skittled for 53 in just 75 minutes on the first morning.England v Australia, 1930: Australia won by seven wickets in Don Bradman's first Test at Lord's. He scored 254, which he later described as 'the best innings of my life'.England v Australia, 1981: Ian Botham's iconic performance with both bat and ball helped England win after following on, one of cricket's greatest comebacks.England v West Indies, 1984: Michael Holding's devastating spell of 6-57 destroyed England, widely regarded as one of the greatest fast bowling performances.England v Australia, 2005: The first Test of the famous Ashes series that ended Australia's reign as world champions, with England's dramatic two-run victory.

The Fatal Helicopter Crash A helicopter crash in northwestern England has killed three British naval crew, according to the UK Ministry of Defence. The crash occurred about 4:00am (03:00 GMT) on Wednesday during a helicopter training exercise near the village of Sourton in the county of Devon, a Royal Navy spokesperson said. Official Response and Investigation The Ministry of Defence announced the news with “deep sadness” in a social media post. “Our thoughts and sympathies are with their families and friends at this sad time,” the ministry said. The navy’s head, General Gwyn Jenkin, said an investigation is under way. Circumstances and Aftermath Few details have been released about the circumstances surrounding the early-morning crash, with the Ministry of Defence saying victims’ families had requested a “period of grace” before further information is made public. British Prime Minister Keir Starmer confirmed he was following the incident. “This will be a deeply worrying time for the families and more information will be set out as soon as possible,” Sky News quoted him as saying. British media reported that several naval bases are located close to where the helicopter went down, including HMNB Devonport, which is Western Europe’s biggest naval base.

The Growing Opposition to Tech Support Cuts for Disabled StudentsDisability campaigners have launched a significant opposition to UK government plans that would remove funding for specialist assistive technology currently available to disabled students through the Disabled Students' Allowance (DSA). With nearly 10,000 people signing a petition against the proposed changes, the debate highlights tensions between technological advancement and specialized support needs in higher education.Department for Education Proposes Replacing Specialist Software with Free AlternativesThe Department for Education (DfE) has announced plans to withdraw funding for specialist assistive software currently provided as part of the Disabled Students' Allowance. According to the DfE, advances in technology mean that free, mass-market tools can now provide equivalent functionality to specialized software, except in "exceptional circumstances."The assistive software currently funded through DSA includes specialized tools for text-to-speech, speech-to-text, mind mapping, composition functions, as well as software to aid research, note-taking, and time and task management. These tools are individually assessed and clinically recommended based on specific student needs.The DfE maintains that students requiring support beyond what free tools can provide will continue to receive funded software through DSA, but critics argue this creates an unnecessary burden of proof for students who already face significant barriers to education.Financial Impact of Disabled Students' AllowanceThe Disabled Students' Allowance represents a substantial financial commitment, with more than 88,000 students benefiting in 2023-24 at a cost of £203 million. This funding has been crucial in providing equal educational opportunities for disabled students across higher education institutions in England.The proposed changes would redirect this funding away from specialized assistive technology toward more general solutions, potentially affecting the quality and effectiveness of support available to disabled students.Industry and Student Voices Oppose the Proposed ChangesThe British Assistive Technology Association (BATA) has strongly criticized the government's position, stating that free, general-purpose tools "do not provide equivalent functionality" to individually assessed, clinically recommended specialist tools. For many disabled students, these specialized technologies represent the difference between participating in higher education and being unable to do so at all.Student testimonials highlight the critical nature of these tools. Sam Wood, a second-year criminology student with severe visual impairment, explained that DSA-funded specialist tech "levels the playing field" by providing tools like Scholarcy and MindView that make academic materials accessible and manageable.Similarly, Helena Mok, a neuroscience student with fibromyalgia and ADHD, emphasized how specialized tools like Tailo provide tailored educational support that generic AI tools cannot match. "Asking a generic chatbot a scientific question just results in a long-winded, inaccurate wall of text," she noted.Industry voices also expressed concern. Chris Purcell, co-founder of assistive technology company CareScribe, described the proposed changes as "abandonment" that would strip away the adjustments making study possible and expose disabled students to avoidable failure.Future Outlook for Disabled Student Support in Higher EducationAs the government consultation on the proposed changes closes on June 18, the debate continues over the balance between technological advancement and specialized support needs. The outcome will likely have significant implications for disabled students' access to higher education and their ability to succeed academically and professionally.Disability advocates argue that while technological progress should be embraced, it should not come at the expense of specialized support that addresses the unique needs of disabled students. The petition and growing opposition suggest that the government may face considerable pressure to reconsider or modify its proposals.The long-term impact of any changes to the DSA could extend beyond higher education, potentially affecting employment opportunities and social inclusion for disabled individuals in the UK.

The Lead: Stokes' Defense of Archer's IPL Commitment Ben Stokes has defended England's decision to excuse Jofra Archer from the start of the Test summer so he could compete in the Indian Premier League, saying a more militant approach risks a situation where "players like him might not play for England again." While Stokes admitted he "totally understands people's frustrations around the situation," particularly given that Archer is tied to an ECB central contract which runs until 2027, he suggested its most high-profile critics were stuck in the past. The Modern Cricket Landscape: Player Opportunities and Expectations "There's another side to it, and a lot of it's got to do with the landscape of cricket and where it is at the moment," England's Test captain said. "I think a lot of the points that people have been making around Jof and that situation are to do with the landscape when they were playing. But it's completely different now. There's opportunities for cricketers now that there wasn't 10, 15, 20 years ago. "Yes, in an ideal situation it would be unbelievably great to have everyone you want available at every single opportunity. That is not the way of cricket at the moment. There is so much more out there for players. There are other opportunities and you want players to be able to do them, and also to play for England. The Archer Situation: IPL Success and Test Uncertainty Archer has just completed his most successful IPL season, taking 25 wickets for Rajasthan Royals as they reached the playoffs, putting him third in this year's bowling rankings. He played his last game on Friday, before flying to Barbados for what Brendon McCullum, the England coach, described as "a little bit of a break". He is expected to play some part in the Test series against New Zealand but will not be at Lord's when the first Test starts on Thursday, and it is not yet known whether he will be available for the second game, which begins at the Oval on 17 June. Criticism and Counterarguments: Former Players vs. Current Leadership "It's ludicrous, absolutely ludicrous," Doull told Sky. "How are you paying this guy up to £1m a year and he's not available for your first Test match? There's no reason that Jofra Archer couldn't have been bowling six or seven overs [with the red ball] in between [games]. The fact that he is not doing that tells me he has no interest in playing Test cricket. And why are the ECB not then having discussions with the [Royals] team, saying: 'We need him to be ready for Test match cricket'? I think it's completely wrong." But while Stokes acknowledged the criticism, he maintained his position: "There is a situation where it could get messy, and players like Jofra might not play for England again if you handle it in a different way, and that is not good for anyone. Jofra has shown that he's committed and loves playing for England. Just because he's not available for this first Test match does not change that." England's Performance Issues: Need for a Smarter Approach Stokes admitted that his team had developed a habit of "consistently letting ourselves down" at crunch moments in Test matches, a trend which their much-trailed reset is intended to address. "It's not a massive change, to be honest," he said. "As much as people want to hear us say that, it's not. It's being a lot smarter in those big moments in games, because I will admit that consistently when [they] were in the balance, when it was neither one way nor the other, we let ourselves down. The decisions we thought were the right ones to make let the opposition get ahead of us. Especially over the past 18 months, we've contributed towards losing games of cricket on too much of a consistent basis."

The Lead: Averting a Wimbledon CrisisThe All England Lawn Tennis Club (AELTC) is actively working to ensure that the upcoming Wimbledon Championships remain free of the player protests that have recently overshadowed the tennis tour. Following a productive meeting with player representatives at Roland Garros, organisers are optimistic that a major dispute over revenue sharing and prize money can be peacefully resolved.Behind the Scenes at Roland GarrosTensions reached a boiling point during the build-up to the French Open, prompting top players to take forceful action. Led by representatives including former WTA chief executive Larry Scott, the players initiated a targeted media boycott. Key figures such as world No. 1s Aryna Sabalenka and Jannik Sinner limited their media availability to just 15 minutes, refusing to engage with tournament rights holders. This strategic move was designed to pressure Grand Slam tournaments into addressing player demands for a greater share of revenues, better welfare contributions, and a dedicated Grand Slam player council.The Financial Stakes for Grand SlamsThe core of the dispute lies in the financial distribution of the sport's most prestigious events. The players have made it clear that recent prize money increases are insufficient.French Open 2026 Purse: £52.6m (a 9.5% increase from the previous year, which players deemed inadequate).Wimbledon 2025 Purse: £53.5m, setting a high baseline for this year's expectations.The AELTC strategically delays finalizing its prize pool until just before the announcement, allowing them flexibility to adjust their financial contributions based on current player sentiment and market pressures.The Escalation of Player LeverageThe recent meetings signal a shift in the balance of power between the tournaments and the athletes. The French Tennis Federation (FFT) has already agreed to provide a concrete counter-proposal to the players' demands after the French Open. However, no such agreement was reached with the AELTC, leaving Wimbledon's upcoming financial announcement as the ultimate litmus test for the All England Club's willingness to accommodate the players' evolving demands.The Decisive Moment Next ThursdayAll eyes are now on the AELTC's prize money announcement scheduled for next Thursday. If the increase is deemed substantial enough to respect the players' demands for higher revenue sharing and welfare support, the tournament will likely proceed without disruption. If it falls short, the tennis world could see an escalation of the media boycotts or even potential tournament boycotts, as previously hinted by Sabalenka. With Wimbledon set to begin on 29 June 2026, the upcoming financial reveal will dictate the immediate future of player-tournament relations.

The Lead The next chapter of Marcus Rashford's dysfunctional relationship with Manchester United may involve a long summer waiting to discover where he plays next season. A state of limbo for a forward expected to start England's World Cup opener against Croatia on 17 June in Dallas is an unusual predicament. Barcelona's Title Clinching Performance Yet this is the latest juncture in a period of career uncertainty that began when the former head coach Ruben Amorim excluded Rashford from his first-team plans. That was in December 2024, loans at Aston Villa and Barcelona followed, and Rashford is still looking to put down roots, perhaps in Catalonia, something he may well have expected to transpire after scoring a free-kick against Real Madrid that proved pivotal in Barcelona's La Liga-clinching victory earlier this month. Financial Complications in Potential Transfer Having enjoyed a generally successful spell under Hansi Flick last season, Rashford's stated preference would be to sign permanently for Barcelona. "I am not a magician but if I was, I would stay," he said after scoring against Real on 10 May. "We will see." The problem is Barça's interest in the 28-year-old is opaque. Anthony Gordon's £69m arrival from Newcastle last week confuses the picture further given he, too, is a left-sided attacker. And if Barcelona want Rashford at all it seems it would again only be on a temporary basis. United, meanwhile, would insist on a £26m permanent fee as they attempt to make money on a player reared in their academy before his contract expires in May 2028. Behind the Transfer Saga The answer to why the price is low for a footballer in his peak years offers a clue to the whole saga: behind the sum is Rashford's £17.5m a-year salary, or the total £35m left to pay on his current terms. United want to offload the cost of the high wage. If Rashford is loaned again, the recruiting club will have to cover all or most of the cost. A permanent transfer will, too, surely feature a raise. As things stand, Barcelona do not appear minded to make any move for Rashford permanent. Potential Destinations Beyond Barcelona What are Rashford's other options? With the caveat of never saying never, there seems no way back for him at United, despite Amorim's departure and the appointment of Michael Carrick as his permanent successor. The lad from Wythenshawe remains firmly persona non grata for Sir Jim Ratcliffe, United's minority owner and controller of football policy, as well as for his senior management team: Jason Wilcox, the director of football, and Omar Berrada, the chief executive. When Rashford's loan move to Villa ended last summer, his aim was to join a Champions League-qualified club but not one in London. If this position has changed, Arsenal may be a potential destination. Mikel Arteta would surely categorise Rashford as an upgrade on Leandro Trossard and Gabriel Martinelli as a left-sided attacking option for the Premier League champions. Rashford's ability to operate at No 9 would also offer a further permutation there, alongside Kai Havertz and Viktor Gyökeres. The same holds at Liverpool, where Cody Gakpo is Liverpool's only senior left-sided option and whose output last season was, at best, middling. If they came calling, would Rashford's disaffection with United prove searing enough for him to ignore tribal loyalties and move to Anfield? Villa, too, may be a desirable destination – Rashford lit up Unai Emery's side when there, especially in the Champions League – while another move abroad also remains a possibility. Paris Saint-Germain have been admirers, albeit it feels unlikely the two-time Champions League winners would move for Rashford given they have the world-class Khvicha Kvaratskhelia operating on the left-hand side of their attack. At Bayern Munich, meanwhile, Luis Díaz is established in the position and at Real Madrid there is Vinícius Júnior. World Cup as Career Turning Point Rashford's next destination is likely to become clearer when the transfer window opens on 15 June but maybe only slowly due to the complexities of his situation, the different agendas of different parties and the World Cup, which should be Rashford's prime focus. United could stymie any deal not deemed desirable to them. But Rashford could also refuse any move he does not want. Assessing this fraught dynamic is a cast of admirers who may well want to add a player who helped Barcelona retain the La Liga title but wonder if they can actually afford him. Rashford remains an enigma. A return of eight goals and nine assists in La Liga last season was a relatively modest return and may explain Barcelona's caution regarding a permanent deal for him. This may change. Imagine, for instance, an England World Cup campaign lit up by Rashford. In this scenario, a £26m fee plus a high-end salary may seem cut-price.