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Tottenham Hotspur is on the verge of appointing Roberto De Zerbi as their new manager following productive talks on Monday. The Italian coach has emerged as the club's top choice to replace Igor Tudor, who left his interim position on Sunday after failing to improve the team's form.De Zerbi, who recently parted ways with Marseille, is now the only viable candidate for the role, with Spurs not engaging with other potential candidates. The club aims to secure his services on a long-term contract, believing he can help them stay in the Premier League and build for the next season.The potential appointment of De Zerbi could also impact Mauricio Pochettino's chances of returning to the club. Pochettino, currently managing the US national team, had been considered for an emotional return to Spurs in the summer, but De Zerbi's possible arrival might rule out that move.De Zerbi's backing of Mason Greenwood during his time at Marseille has raised concerns among some Tottenham supporter groups. Greenwood was charged with attempted rape and assault in 2022, although the case was later discontinued. Despite these concerns, Spurs seem willing to overlook them to secure De Zerbi's appointment.The situation at Tottenham is critical, with the team currently one point and one place above the relegation zone and having gone 13 league matches without a win – their worst run since the 1934-35 season. De Zerbi's task would be to turn the team's fortunes around and secure their Premier League status.

Dua Lipa, the Brit award-winning pop star, has been announced as the curator of this year's London literature festival at the Southbank Centre. The festival, now in its 19th year, will run from October 21 to November 1.Lipa will shape the programme of events across the opening weekend and beyond in collaboration with her Service95 book club, which she launched in 2023. This initiative is part of the Southbank Centre's 75th anniversary programme and during the UK's National Year of Reading.Lipa has established herself as a prominent advocate for reading through her book club, where she spotlights established writers and emerging voices. She has interviewed notable authors such as Margaret Atwood, George Saunders, and Olga Tokarczuk.“Reading has anchored me through every chapter of my life,” Lipa said. “Curating the Southbank Centre’s London literature festival is a dream come true. I’m thrilled to indulge one of my greatest obsessions: books and the brilliant minds behind them.”Mark Ball, artistic director of the Southbank Centre, praised Lipa's passion for literature, stating, “Dua Lipa is a global cultural force with millions of fans around the world, and her passion for the written and spoken word has inspired a new generation of readers.”The 2026 edition will feature a mix of ticketed and free events, highlighting both Lipa's favourite writers and new literary voices. The full programme is expected to be announced over the summer.

Eli Lilly, the US pharmaceutical group behind the Mounjaro weight-loss drug, is seeking to resume its investments in the UK after pausing them last year. The company is in talks with UK ministers to regularly increase NHS drug prices and end a rebate scheme. Patrik Jonsson, president of Eli Lilly's international business, expressed optimism about reaching an agreement this summer.The talks will also explore 'innovative' pricing plans, such as linking payments for anti-obesity drugs to whether the treatment helps patients return to work. This comes as the US pharmaceutical industry increases pressure on the UK, with Keir Starmer agreeing to the first increase in NHS cost-effectiveness thresholds in 27 years. The threshold was raised from £20,000 to £30,000 a year for every year of life gained to £25,000 to £35,000.Eli Lilly was one of several pharmaceutical companies that ditched or paused almost £25bn in planned investments in the UK last year. The company paused its plans to invest in a laboratory site in central London. Jonsson stated that the resumption of Eli Lilly's investment would depend on the outcome of its talks with the government.He emphasized that prices for medicines in the UK had been 'far too low for far too long' and that the threshold couldn't remain static for another three decades. The UK agreed to pay 25% more for new medicines by 2035 as part of a US-UK drug pricing deal, which could eventually reach £9bn a year.Large pharmaceutical companies have protested about a 'rebate' scheme, under which they are required to pay back a chunk of revenue from sales of branded medicines. This scheme is expected to fall in 2026, although Jonsson believes payments 'should actually get down to zero' over time.

The Houthis are a militant group that emerged from a years-long civil war in Yemen as the country’s most powerful political force. Their strategic location at the entrance of the Red Sea allows them to disrupt international trade.The group, which has an estimated 20,000 fighters, represents the Zaidi branch of Shia Islam. The Houthis first began gaining mass support around the turn of the century from Shia Yemenis who were fed up with corruption and authoritarian leaders.In 2014, the Houthis captured the Yemeni capital, Sana’a, and a year later overthrew the western-backed president, Abd-Rabbu Mansour Hadi. Hadi was forced to flee, but his allies in Saudi Arabia and the UAE launched a military campaign, also backed by the west, to drive out the Houthis.The ensuing civil war led to an estimated 377,000 deaths and displaced 4 million people by the end of 2021. The UN brokered a 2022 truce between the warring sides in Yemen that has largely held.As part of Iran’s “axis of resistance”, the Houthis began targeting international shipping in the Red Sea after the 7 October 2023 attack on Israel by Hamas, which triggered the Israeli military campaign in Gaza. The Houthis’ campaign in the Red Sea – a major thoroughfare for world trade – brought chaos to global supply chains.The Houthis ceased their attacks after a US-brokered ceasefire between Israel and Hamas in October 2025.While the US says Iran has armed, funded, and trained the Houthis, the group denies being an Iranian proxy but says they share a political affinity. On 28 March, the Houthis fired missiles at Israel, vowing to continue military operations until Israel “ceases its attacks and aggression”.

A devastating attack by Sudanese paramilitaries on South Kordofan has claimed the lives of at least 14 people, including five children and two women, according to a medical group. The Rapid Support Forces (RSF) and their allies in the Sudan People's Liberation Movement–North launched a hours-long assault on residential areas in the city of Dilling, leaving at least 23 others wounded, including seven children.The Sudan Doctors Network reported that the attack was part of a larger conflict that has ravaged the region. The military, which recently broke an RSF siege on the city, said it successfully fended off the attack on the capital of South Kordofan province.The doctors' group warned of a possible “catastrophic scenario” similar to the one that occurred in the Darfur city of el-Fasher. The RSF's invasion of el-Fasher in October was marked by “hallmarks of genocide”, according to UN-commissioned experts. More than 6,000 people were killed over three days in el-Fasher when the RSF unleashed a wave of intense violence.The war between the Sudanese army and the RSF, which began in mid-April 2023, has led to one of the world's fastest-growing man-made humanitarian crises. Over 12 million people have been forced from their homes, and more than 33 million people are in need of humanitarian aid. According to UN figures, more than 40,000 people have been killed over the past three years, although aid groups believe the true death toll could be significantly higher.Both sides have been accused of war crimes and crimes against humanity, which are being investigated by the International Criminal Court. The fighting has recently centered on Darfur and the Kordofan region, with deadly drone attacks reported daily. The UN Human Rights Office reported that more than 500 civilians were killed in drone strikes this year as of mid-March.

Demonstrators took to the streets of cities across the United States for the first 'No Kings' protest since the joint US and Israeli war against Iran began one month ago. The protests, which mark the third round of nationwide 'No Kings' demonstrations, saw over 3,300 events planned across all 50 states, with large crowds expected in cities such as New York, Los Angeles, and Washington, DC.The main event was scheduled for the Minneapolis-St Paul area in Minnesota, known as the Twin Cities, which became a focal point for Trump's hardline immigration crackdown in December. More than 3,000 federal immigration agents descended on the Twin Cities, leading to accusations of excessive force during deportation raids.In January, agents shot and killed two US citizens, Alex Pretti and Renee Nicole Good, prompting nationwide outrage and calls for reform. Dozens of lawsuits have been filed as a result of the operation, which was wound down in February.Progressive Senator Bernie Sanders addressed attendees, and rock icon Bruce Springsteen performed at the event, along with folk singer Joan Baez. Actor Robert De Niro told the crowd in Minnesota in a pre-recorded address, 'You've shown bravery in the face of armed attack by government thugs, and you stood together and ran them out of town'.The previous two 'No Kings' marches took place in June and October and drew millions of people. Trump responded to the October protest by posting an AI-generated video depicting himself dumping faeces on the protesters. The US is currently in the midst of campaigns for its pivotal midterm elections in November, which will see Trump's Republican Party seek to defend its majorities in both chambers of Congress.Democrats are hoping to gain seats as Trump's popularity droops. Sanders was among the speakers who reminded protest attendees of the importance of the upcoming vote, saying, 'We will not allow this country to descend into authoritarianism or oligarchy. In America, we the people will rule'.

Robert F Kennedy Jr, the US health secretary, has unveiled a chaotic and unpredictable agenda for public health policy under his 'Make America Healthy Again' (Maha) initiative. His approach tends to favor personal choice and autonomy over large-scale, mandatory public health interventions, such as childhood vaccine requirements.The Maha agenda has raised concerns over the potential risks associated with injectable peptide drugs. Mr. Kennedy plans to open up the sale of 'about 14' of these drugs to the public, despite the US Food and Drug Administration (FDA) restricting 17 peptides in 2023 due to 'potential significant safety risks'. None of these peptides have been proven to be safe or effective for human use.The peptides in question are often promoted for biological enhancement, such as increasing muscle mass or cognitive benefits, but the evidence for these effects in humans is thin. Reports of people self-administering peptide therapies, usually bought from China 'for research use only', are widespread, particularly in Silicon Valley.The Maha project wants to make the grey market the only market, effectively sanctioning mass public use of unproven treatments. Peptides are clearly drugs and shouldn’t be allowed for widespread use without rigorous clinical trials. Opening loopholes for sale would undermine the precautionary principle that has successfully led public health policy for generations.It is also worth noting that other governments are unlikely to be as cavalier as Mr. Kennedy about peptides. However, people everywhere will continue to call for more personal choice and more bodily autonomy, and those conversations are important. The case for safety, proof, and regulation must be made to ensure that public health policy prioritizes the well-being of individuals.

The UK television landscape has undergone a significant change this Easter, as new regulations banning junk food advertising before 9pm have taken effect. For the first time, viewers will not be subjected to a barrage of advertisements for chocolate eggs and hot cross buns during their Easter celebrations.The regulations, which came into force at the beginning of the year, aim to tackle rising childhood obesity by prohibiting products high in fat, sugar, and salt from appearing in TV ads before 9pm. This move has resulted in a sugar-free viewing experience for UK audiences during Easter.The impact on the advertising industry has been notable, with TV advertising spending by confectionery and snacks brands almost halving year-on-year between October and February. Overall TV ad spend is down at least 15% year-on-year.Industry bodies and broadcasters have argued that the ban is more political PR than an effective policy, with the chief executive of ITV, Carolyn McCall, and former Channel 4 boss, Alex Mahon, pointing out that the government’s own research showed that the number of calories saved would be 1.7 a day, about a third of a Smartie.Campaigners argue that big food companies are compensating for the ban by upping marketing budgets on other media, such as outdoor media and radio. A battle is already brewing over the likely introduction of further restrictions, with the government launching a consultation on adopting a newer nutrient profiling model that would deem a far wider range of products too high in fat, salt, and sugar.

The new HBO Max series Portobello had all the makings of a gripping drama: a charismatic TV host, a mind-controlled parrot, and allegations of mafia involvement. However, the show's pacing and tone leave much to be desired.Based on the true story of Enzo Tortora, the former host of Italy's top TV show, Portobello explores the intersection of celebrity, politics, and organized crime. The series' setting in the 1980s and its themes of false accusations and the power of the media are certainly relevant today.Despite its potential, the show's execution is wildly dull. The 72-minute first episode feels like a slog, and the period-authentic aesthetic, while well-intentioned, doesn't quite make up for the lack of tension or excitement. Even the bizarre subplot involving a mind-controlled parrot and its owner's obsession with Tortora can't seem to elevate the show's overall pace.The show's portrayal of the justice system is also noteworthy, highlighting the Kafkaesque experience faced by Tortora as he navigates the complexities of the law. However, this powerful theme is often overshadowed by the show's meandering pace and lack of dramatic tension.Ultimately, Portobello feels like a missed opportunity to create a compelling drama about a fascinating true story. While it may appeal to fans of character-driven dramas or those interested in Italian culture, others may find themselves checking their watches.