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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Joe Eszterhas, the swaggering pitchman of 80s and 90s Hollywood, has lived a life of excess and creativity. He wrote hits like Jagged Edge and co-scripted Flashdance, earning a then-record $3m for his Basic Instinct screenplay.Eszterhas's life story is a harrowing, rollicking immigrant's tale that whisks its hero from his birth in war-torn Hungary through the refugee camps of Allied-occupied Austria to the US rust belt. He covered the Kent State massacre as a cub reporter and interviewed Charles Manson in prison.Now 81, Eszterhas is plotting a Hollywood comeback with a rebooted Basic Instinct. He received a reported $2m from Amazon MGM studios for his script and stands to make a further $2m if and when it is filmed. The new story juggles copycat serial killers with elements of the supernatural.Eszterhas has always relished a good public scrap, and his reboot is described as anti-woke. This has sparked concerns that he may be co-opted and become a political football. However, Eszterhas insists that he is not afraid of controversy and sexuality.Despite his past struggles with drinking and drugs, Eszterhas has been clean and sober for decades. He has written a 750-page memoir, Hollywood Animal, and told his Tinseltown war stories on a recent multi-part media podcast, Ugly, Irresponsible, & Childish.

Scientists have made a groundbreaking discovery, identifying a distinct 'neural fingerprint' produced by psychedelic drugs in the human brain when users experience their mind-altering effects.This breakthrough finding emerged from a comprehensive study that combined 11 brain imaging datasets from around the world, involving over 500 brain scans from 267 people in five countries. The research focused on five psychedelic substances: LSD, psilocybin, DMT, mescaline, and ayahuasca.The study revealed that these substances have a shared impact on the brain's behavior, dissolving the usual hierarchy of brain systems and flattening the hierarchy, which may underlie the raw access to one's own consciousness that some people describe during psychedelic experiences.Dr. Danilo Bzdok, a senior author on the study from McGill University in Montreal, Canada, explained that all five drugs change brain function in common ways, despite some differences in how they alter brain activity. The most striking effect was stronger communication between brain networks that engage in higher-level thinking and more primitive networks linked to vision and sensation.The research, published in Nature Medicine, provides a solid foundation for psychedelic research, which is crucial if these drugs are to become widespread therapies for mental health conditions such as depression, schizophrenia, and post-traumatic stress disorder.Dr. Emmanuel Stamatakis, a senior co-author on the study from the University of Cambridge, emphasized the importance of large-scale, coordinated evidence in the field of psychedelic research, which is moving quickly and needs to mature responsibly.

The peptide-testing industry has seen a significant surge in demand, with laboratories testing thousands of unregulated substances claiming to support weight-loss and wellness. This growth is largely driven by the injectable peptide craze, with experts warning about the lack of reliable safety data and quality control.Peptides are short chains of amino acids, which can be found naturally in the body or made synthetically in laboratories. They include active ingredients in prescription weight-loss drugs, such as Wegovy, as well as experimental compounds pushed online by the booming biohacking and anti-ageing industries.Laboratories, such as Finnrick in Texas, have reported a substantial increase in testing requests, with around 60,000 samples processed annually, including roughly 2,000 orders from the UK since 2024. About a third of the products analysed failed basic quality checks, with issues including incorrect identity, purity, and quantity.Experts, including Dr. Luke Turnock and Peter Magic, have highlighted the risks associated with these unregulated substances, including potential long-term harms such as increased cancer risk and damage to organs. The large profit margins have also drawn nefarious actors into the supply chain.The UK is a significant market for peptides, with 2,000 testing orders since 2024, tied with Canada for third place globally. The Royal Pharmaceutical Society's Prof Amira Guirguis emphasized the need for oversight, traceability, and quality assurance in the peptide market.

Donald Trump has repeatedly framed inflation as a "hoax" and declared that he has "won affordability," yet independent analyses reveal that his touted initiatives deliver only marginal relief for most Americans.One of his most publicized programs, the TrumpRX prescription‑drug platform, lists just 61 medications out of the thousands needed nationwide. Moreover, price comparisons show that a medium dose of Wegovy costs $349 on TrumpRX, while the same dose sells for $163 in Japan and $198 in Germany. Similar gaps appear for diabetes drug Xigduo and autoimmune medication Xeljanz, which are significantly cheaper abroad.The website markets itself as a solution for uninsured, cash‑paying patients, but it does nothing for the roughly 85 % of Americans who already have prescription coverage.On housing, Trump’s executive order banning Wall Street firms from buying single‑family homes is unlikely to move the needle. Institutional investors own only about 2 % of such homes, while the nation faces a shortage of roughly 4.7 million units, according to Zillow. The ongoing war in Iran has also pushed mortgage rates higher, further straining affordability.Gasoline prices have surged since the Iran conflict began, climbing to an average of $4.10 per gallon – a 37 % increase from the pre‑war level of $2.98.Food costs tell a similar story. The Consumer Price Index shows a 3.1 % rise in overall food prices from February 2025 to February 2026, with coffee up 18.4 %, beef up 14.4 %, and fresh vegetables up 5.4 %. Tariffs championed by the administration have contributed to these hikes.International bodies echo domestic concerns. The OECD projects U.S. inflation to exceed 4 % this year, largely driven by the Iran war, a level higher than the 3 % rate recorded at the end of the Biden administration.Trump also claims to have eliminated taxes on overtime and Social Security benefits. In reality, overtime earnings are still subject to federal income tax on the base wage and to full Social Security and Medicare payroll taxes. Only the overtime premium enjoys a partial tax break. Likewise, more than half of Social Security recipients will continue to owe income tax on their benefits, contradicting the administration’s “no‑tax” narrative.Other initiatives, such as the “Trump Accounts” child‑savings program, provide a one‑time $1,000 seed deposit and allow families to contribute up to $5,000 annually. While beneficial for affluent households, the scheme offers limited assistance to families living paycheck‑to‑paycheck.Policy decisions have also raised costs for vulnerable groups. By opposing extensions of Obamacare subsidies, average health‑care premiums have risen by over 20 % for more than 20 million people. Simultaneously, proposed cuts to LIHEAP threaten heating and cooling assistance for roughly 6 million low‑income households.In sum, Trump’s affordability rhetoric serves more as political branding than substantive economic relief. The modest scope of his programs and the persistence of rising prices suggest that most working‑class Americans will see little improvement in their day‑to‑day expenses.

Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

American consumers are watching gasoline and airline fares climb, while economists warn that the war in Iran will keep pressure on prices across the U.S. economy.“The good old days are gone,” said Christopher Tang, a professor at UCLA’s Anderson School of Management who studies global supply chains. “We see gasoline prices rising now, but that’s only the tip of the iceberg; everything will become more expensive.”Since the conflict began in late February, crude oil has surged past $110 a barrel. The rally is tied to Iran’s leverage over the Strait of Hormuz, a narrow chokepoint through which roughly 20% of the world’s oil passes.In a recent address, President Donald Trump claimed the United States is “totally independent of the Middle East” and has “plenty of gas.” However, Brookings Institute’s energy‑security director Samantha Gross reminded listeners that oil is a globally traded commodity and the U.S. still imports significant volumes, meaning American consumers will face the same high prices as the rest of the world.Iran has either halted shipments through the strait or imposed a toll of up to $2 million per vessel. Tankers are forced to take longer routes or pay the fee, inflating logistics costs for all downstream users.Major logistics players are already passing those costs on. Amazon announced a 3.5% surcharge for third‑party sellers, while UPS and FedEx have introduced fuel surcharges exceeding 25%. The United States Postal Service will add an 8% surcharge to transportation rates starting 27 April, noting the charge is “less than one‑third of what our competitors charge for fuel alone.”When the prices go up, they rarely come back down— Christopher Tang, UCLACountries have dipped into strategic oil reserves to blunt the shock, but economists such as Virginia Tech’s David Bieri warn that refilling those stockpiles will require buying oil at today’s elevated prices, keeping the upward pressure on the market.Higher oil costs ripple beyond fuel. Crude is a key feedstock for chemicals, pharmaceuticals and fertilizers, meaning the surge could translate into higher prices for prescription drugs and groceries.Cornell University’s agricultural economics professor Christopher Wolf explained that diesel, a major input for farm equipment and fertilizer production, is also climbing, raising the cost of both crop cultivation and livestock raising.Retailers and food processors are already adjusting. “If we anticipate higher costs, we start raising prices early to avoid a sudden shock later,” Wolf said, describing a “rational expectations” approach.The Independent Grocers Alliance warned that a 10‑15% rise in fuel costs could lift food prices by 2‑4% by mid‑summer, underscoring the broader impact on household budgets.Although President Trump expects the United States to exit the Iran conflict within two to three weeks, experts agree that even a swift resolution will not instantly reverse the price spikes.The strait’s strategic importance means the political risk premium on oil will linger. “You never know when this could flare up again,” said Northeastern University’s Ravi Ramamurti, adding that the effect is likely to be persistent.As Tang summed up, “When the prices go up, they rarely come back down.”

President Donald Trump has taken a significant step to push for pharmaceutical deals by signing an executive order that could impose tariffs of up to 100% on some patented drugs. This move is part of his administration's effort to secure lower prices for medicines.Under the executive order, companies that have signed a 'most favoured nation' pricing deal and are actively building facilities in the US will have a zero-percent tariff. For those that don't have a pricing deal but are building such projects in the US, a 20 percent tariff will apply, but it will increase to 100 percent in four years.A senior administration official stated that companies still have months to negotiate before the 100 percent tariffs kick in. Bigger companies will have 120 days, and 180 days are offered for everyone else.The administration has already reached 17 pricing deals with major drugmakers, 13 of which have signed. The executive order aims to address the threatened impairment of national security posed by imports of pharmaceuticals and pharmaceutical ingredients.Critics, pharmaceutical leaders, and medical groups have warned of the consequences the new tariffs could bring, including increased costs and potential jeopardy to billions in US investments. The pharmaceutical company trade group PhRMA has expressed concerns that taxes on cutting-edge medicines will increase costs and could jeopardize investments.

French authorities detained European Parliament member Rima Hassan on Thursday, accusing her of "apology for terrorism" after a social‑media post referenced Kozo Okamoto, a participant in the 1972 Ben Gurion Airport attack. The detention, reported by Le Parisien, marks a rare instance where a sitting MEP’s parliamentary immunity appears to have been set aside. According to the newspaper, Hassan had already removed the contentious post from X, but the investigation continued. Police also reported finding a small quantity of synthetic drugs in her possession during the arrest. Jean‑Luc Mélenchon, founder of the left‑wing La France Insoumise (LFI) party, condemned the move on X, stating, "There is no longer parliamentary immunity in France. Intolerable." He and other LFI colleagues argue the action is designed to silence supporters of Palestine. LFI parliamentarians Sophia Chikirou and Mathilde Panot echoed the criticism, accusing the French police and justice system of being weaponised against activists. Panot warned that President Emmanuel Macron’s France is witnessing a "new level" of criminalisation of political opponents. The controversy follows Hassan’s recent denial of entry to Canada, which she described as censorship, and a prior alert by far‑right National Rally politician Matthias Renault to Paris prosecutors about the same X post. Renault welcomed the detention, calling it "the beginning of the end of impunity for the LFI MP." Hassan, a 33‑year‑old French‑Palestinian lawyer elected to the European Parliament in 2024, is a vocal critic of Israel’s war in Gaza and participated in a Gaza‑bound flotilla intercepted by Israeli forces in October 2025. Her advocacy has repeatedly drawn ire from pro‑Israel groups across Europe. While Hassan and her legal team have not responded to Reuters’ requests for comment, the incident raises broader questions about the balance between anti‑terrorism legislation and political freedoms within the EU, especially as debates over Palestine intensify across the continent.